Antimicrobial activity of a new intact skin antisepsis formulation

Russo, Antonello; Viotti, Pier Luigi; Vitali, Matteo; Clementi, Massimo

doi:10.1067/mic.2003.41

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…We now report that urea in combination with citric acid can enhance the virucidal activity of ethanol solution (ca 70 %) and inactivate all reference viruses of the DVV/RKI Guideline within 1 min exposure time. Tests with bacteria and fungi are still under investigation for this antiseptic formulation which requires a broad spectrum as shown earlier for a product based on chlorine and alcohol [ 41 ]. The virucidal activity of concentrated aqueous urea solutions against PV is well known from early experiments with monkeys [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid

Ionidis¹,

Hübscher²,

Jack³

et al. 2016

BMC Infect Dis

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BackgroundHand disinfectants are important for the prevention of virus transmission in the health care system and environment. The development of broad antiviral spectrum hand disinfectants with activity against enveloped and non-enveloped viruses is limited due to a small number of permissible active ingredients able to inactivate viruses.MethodsA new hand disinfectant was developed based upon 69.39 % w/w ethanol and 3.69 % w/w 2-propanol. Different amounts of citric acid and urea were added in order to create a virucidal claim against poliovirus (PV), adenovirus type 5 (AdV) and polyomavirus SV40 (SV40) as non-enveloped test viruses in the presence of fetal calf serum (FCS) as soil load. The exposure time was fixed to 60 s.ResultsWith the addition of 2.0 % citric acid and 2.0 % urea an activity against the three test viruses was achieved demonstrating a four log10 reduction of viral titers. Furthermore, this formulation was able to inactivate PV, AdV, SV40 and murine norovirus (MNV) in quantitative suspension assays according to German and European Guidelines within 60 s creating a virucidal claim. For inactivation of vaccinia virus and bovine viral diarrhea virus 15 s exposure time were needed to demonstrate a 4 log10 reduction resulting in a claim against enveloped viruses. Additionally, it is the first hand disinfectant passing a carrier test with AdV and MNV.ConclusionsIn conclusion, this new formulation with a low alcohol content, citric acid and urea is capable of inactivating all enveloped and non-enveloped viruses as indicated in current guidelines and thereby contributing as valuable addition to the hand disinfection portfolio.

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Section: Discussionmentioning

confidence: 99%

Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid

Ionidis¹,

Hübscher²,

Jack³

et al. 2016

BMC Infect Dis

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“…On the basis of their unique chemical structure and antibacterial functions, N -halamines are being explored for other important applications. ,,,,,,− For instance, Williams et al developed melamine-containing N -halamines for kitchen work surfaces by imparting antimicrobial properties to the materials in furniture surfaces, such as plastics, ceramic tiles, cardboard, wood, marble, aluminum, formica, grout cement, and glazed porcelain. They found that antibacterial coatings on a wide variety of hard and soft substrates could be obtained by exposing surfaces treated with N -halamines.…”

Section: Applications Of N-halaminesmentioning

confidence: 99%

“…Interestingly, N -halamines are also used as potent disinfectants in daily life. Russo et al developed a new intact skin antisepsis formulation: a solution containing 0.5% chloramine-T diluted in 50% isopropyl alcohol. Worley’s group , demonstrated that instead of free chlorine, N -halamines acted as effective disinfectants in the egg-processing and poultry-processing industries.…”

Section: Applications Of N-halaminesmentioning

confidence: 99%

Chemical Insights into Antibacterial N-Halamines

et al. 2017

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Microbial contamination arising from pathogens poses serious threats to human health and in recent decades has presented an unprecedented challenge to antibacterial research. Of the various antibacterial agents that effectively kill pathogens, halogen-based antibacterial compounds have been successful in eliminating harmful pathogen-associated diseases and are becoming the most popular disinfectants. As a significant subcategory of halogen antibacterial agents, N-halamines have drawn increasing research interest into their chemistry and practical applications. N-Halamines have many advantages over other antibacterial agents, including effectiveness against a broad spectrum of microorganisms, long-term physicochemical stability, high structural durability, and the regenerability of their functional groups, with corresponding renewal of their antibacterial properties. This review examines recent progress and research trends in both theoretical and experimental studies of N-halamines, with the aim of providing a systematic and comprehensive survey and assessment of the significant advances in our understanding of antibacterial N-halamines. This review serves as a practical guide to developing N-halamines through both broad and in-depth basic research and offers suggestions for their potential future applications.

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“…Therefore, different antiseptic formulations have shown limitations when applied to disinfecting safe skin, notably short-term tolerance and/or efficacy [16]. Several factors affect the activity of antiseptics (e.g.…”

Section: Antiseptic Delivery From Drug Carriermentioning

confidence: 99%

“…When increasing the proportion of alcohol, the proportion of remaining active agents can be reduced, producing a similar antibacterial efficiency [14]. On the other hand, alcohol-based products act rapidly, in spite of their large antibacterial spectrum and higher efficacy against resident flora, compared to scrubs [15,16]. Alcohol rub formulations exhibited more efficiency than liquid soaps for surgical hand disinfection [3,5].…”

Section: Rub Formulationsmentioning

confidence: 99%

Current and New Strategies for the Delivery of Antiseptic Agents

Constant¹,

Falson²,

Pirot³

2006

CDD

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The present mini-review explores the current methods used for the delivery of antiseptics and topical antimicrobials. Relevance of hand scrub with antiseptic liquid soap (e.g. chlorhexidine, PVP-iodine, triclosan) and alcohol-based hand rub is discussed and compared in terms of bactericidal activity, skin tolerance, and medical staff observance. New strategies for antibacterial delivery focus on the challenge of colloidal drug carrier such as liposomes, micro- and nanoparticles enabling sustained bactericidal effect and effective bacterial targeting.

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Antimicrobial activity of a new intact skin antisepsis formulation

Cited by 8 publications

References 20 publications

Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid

Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid

Chemical Insights into Antibacterial N-Halamines

Current and New Strategies for the Delivery of Antiseptic Agents

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