Antimicrobial Activity In Vitro of Cream from Plant Extracts and Nanosilver, and Clinical Research In Vivo on Veterinary Clinical Cases

Popova, Teodora P.; Ignatov, Ignat; Petrova, Toshka; Kaleva, Mila; Huether, Fabio; Karadzhov, Stoil

doi:10.3390/cosmetics9060122

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…These materials are zero-dimensional, with a size range of 1-100 nm and characteristic morphologies [9,10]. Owing to their small size, AgNPs exhibit significant antimicrobial and fungicidal activities as well as biocompatible surface properties [9][10][11][12][13]. Our recent studies have also confirmed the antimicrobial activities of AgNPs as reported in the literature [14][15][16].…”

Section: Introductionsupporting

confidence: 83%

Antibacterial efficacy of greenly synthesized silver nanoparticles using nanocurcumin and silver nanoparticle gel on bovine mastitis

Vo-Van,

Dao,

Nguyen

et al. 2023

Mater. Res. Express

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This study summarizes the synthesis of AgNPs using nanocurcumin as a reducing and stabilizing agent (CurAgNPs). The stability of CurAgNPs after 12 months of storage and their antimicrobial activity against four bacteria that cause mastitis in cows were investigated. Ultraviolet – visible (UV-vis) spectroscopy of the dark brownish-red stabilized CurAgNP solution decating the surface plasmon resonance peak of the sample was observed at 438 nm. Images of the spherical CurAgNPs were obtained using transmission electron microscopy (TEM), which showed a mean particle size distribution of 15–58 nm with a mean size of 32 nm. The influence of CurAgNPs on four microorganisms that cause mastitis in cows, Streptococcus agalactiae (S. agalactiae), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Eschericia coli (E. coli), were studied, and the minimum inhibitory concentration (MIC) ranged from 1.6 to 6.25 ppm. From this, the MBC of CurAgNPs were observed at 3.15 ppm for S. agalactiae, and 6.25 ppm for S. aureus, P. aeruginosa and E. coli, respectively. The formulated homogeneous gel containing 100 ppm CurAgNPs, 1.5 % carbolxymethyl cellulose (CMC), and distilled water was developed with a viscosity of 141 ± 7.55 cP, and pH of 6.72 ± 0.11 and homogenized. In addition, the improved CurAgNP gel demonstrated significant antimicrobial activity compared with tetracycline at a concentration of 100 ppm.

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Section: Introductionsupporting

confidence: 83%

Antibacterial efficacy of greenly synthesized silver nanoparticles using nanocurcumin and silver nanoparticle gel on bovine mastitis

Vo-Van,

Dao,

Nguyen

et al. 2023

Mater. Res. Express

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“…Animal testing is being replaced by in vitro tests in cosmetic product development. The cream-gel analyzed in this study followed this trend [20,21].…”

Section: Discussionmentioning

confidence: 75%

“…Flavonoids are natural phenolic compounds found in plant roots [22]. Due to their proven potential antioxidant activity, these compounds contribute greatly to photoprotection and anti-aging for the skin [14,20,23]. In the extract derived from Agave sisalana roots, a significant concentration of flavonoids, particularly catechin and quercetin, was observed.…”

Section: Discussionmentioning

confidence: 99%

Development of an Antioxidant, Anti-Aging, and Photoprotective Phytocosmetic from Discarded Agave sisalana Perrine Roots

Mazo,

Fracasso,

da Costa

et al. 2024

Cosmetics

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The primary source of hard fiber globally is Agave sisalana Perrine, also known as sisal. In areas where sisal is grown, the roots of the plant are usually left in the field after it has stopped producing, which leads to soil degradation and decreased sisal productivity. It is, therefore, critical to find alternatives to reuse this waste. This study explores the potential use of sisal waste in the cosmetic industry by incorporating a hydroethanolic extract (HER) into a cream–gel formulation, taking advantage of the plant’s recognized ethnopharmacological value. The study involves analyzing the extract’s phytochemical composition (flavonoids) and evaluating its cytotoxicity. Subsequently, the antioxidant and antiglycation activities of the extract and cream–gel are evaluated, as well as ex vivo ocular toxicity, photoprotective activity, and preliminary stability analyses. The HER extract showed a flavonoid composition (catechin, kaempferol, isorhamnetin, and chrysin) and maintained cell viability above 70% throughout all time points analyzed in the MTT assay. Furthermore, the extract and the formulation demonstrated proven antioxidant and antiglycation activities. The cream–gel’s UVB and UVA protection effectiveness with the HER was comparable to that of synthetic UVB/UVA sunscreens, with the samples proving nonirritating and stable. In conclusion, the extract has a significant presence of flavonoids, and the cream–gel developed with it did not present cytotoxicity and met the stability requirements, indicating phytocosmetic potential with antioxidant, antiglycation, and photoprotective properties.

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“…It has also been shown to have a relaxing effect on both vascular and non-vascular smooth muscle tissues [47]. The antimicrobial activity of SS ® cream and successful topical application for treatment of some skin diseases were reported in our previous study [48]. Our preliminary in vitro studies [9, 35,36] have shown that the antimicrobial action of SS ® cream is mainly due to the herbal extracts it contains, as well as to the colloidal nanosilver in the final concentration applied.…”

Section: Resultsmentioning

confidence: 86%

Determination of the Anti-inflammatory and Anti-microbial Activity of a Cosmetic Product Silver Stop® Cream

Dimitrov¹,

Popova

Gotova³

et al. 2023

J. Pharm. Res. Int.

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The anti-inflammatory and antimicrobial effects of a cream containing extracts of African geranium (Pelargonium sidoides DC.), black elderberry (Sambucus nigra L.) and St. John's wort (Hypericum perforatum L.) in colloidal nanosilver (AgNPs) at a concentration of 30 ppm, denoted as SILVER STOP® cream (SS® cream) was examined In vitro. The research was performed with Staphylococcus aureus (ATCC-6538 and two clinical strains). Suspension tests for determination the time of antimicrobial action of SS® cream were used. SS® cream showed significant antimicrobial activity. In suspension with a density of 104 cells.mL-1S. aureus died after 60 minutes of exposure to SS® cream. In suspension with concentration of 106 cells.mL-1, after 2 h only single cells remained viable. The anti-inflammatory effect was evaluated using human epithelial cell line HT-29, incubated with a type strain of S. aureus. After treatment with SS® cream, results have shown a statistically significant reduction of the levels of the pro-inflammatory cytokinesIL-6, IL-8, IP-10 and IL-1β.

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Antimicrobial Activity In Vitro of Cream from Plant Extracts and Nanosilver, and Clinical Research In Vivo on Veterinary Clinical Cases

Cited by 10 publications

References 22 publications

Antibacterial efficacy of greenly synthesized silver nanoparticles using nanocurcumin and silver nanoparticle gel on bovine mastitis

Antibacterial efficacy of greenly synthesized silver nanoparticles using nanocurcumin and silver nanoparticle gel on bovine mastitis

Development of an Antioxidant, Anti-Aging, and Photoprotective Phytocosmetic from Discarded Agave sisalana Perrine Roots

Determination of the Anti-inflammatory and Anti-microbial Activity of a Cosmetic Product Silver Stop® Cream

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