Antimicrobial Activity and Polyphenol Profiles of Hydroalcoholic Extracts of Thymus rasitatus Klokov and Thymus eremita Klokov

Ивасенко, С. А.; Zhumabekova, Ainur; Ludwiczuk, Agnieszka; Skalicka‐Woźniak, Krystyna; Marchenko, Alexandr; Ishmuratova, Margarita; Poleszak, Eva; Korona-Głowniak, Izabela; Ахметова, С. Б.; Karilkhan, Islambek; Loseva, Irina

doi:10.3889/oamjms.2021.6117

Cited by 2 publications

(3 citation statements)

References 8 publications

(12 reference statements)

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“…An ultrasonic 70% ethanolic extract of T. serpyllum in a concentration range of 0.0625 to 20 mg/mL showed bactericidal or bacteriostatic activity against a range of tested bacteria and fungi. However, there is a difference in the strength of action against strains of microorganisms ( 81 ), and the ethanolic extract was considered equally effective against gram-positive and gram-negative bacteria compared to clove oil ( 108 ). The bactericidal activity of the aqueous ethanolic extract of T. serpyllum for gastrointestinal disorders in a concentration range of 7.8 μg/mL – 500 μg/mL showed growth inhibition of Heliobacter pylori at 500 μg/mL in all strains ( 111 ).…”

Section: Resultsmentioning

confidence: 99%

“…The ethanol and chloroform extract of T. serpyllum were investigated in a number of in-vitro assays for their antibacterial activities (81,91,(107)(108)(109)(110). An ultrasonic 70% ethanolic extract of T. serpyllum in a concentration range of 0.0625 to 20 mg/mL showed bactericidal or bacteriostatic activity against a range of tested bacteria and fungi.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

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Wild thyme (Thymus serpyllum L.): a review of the current evidence of nutritional and preventive health benefits*

Jalil,

Pischel,

Feistel

et al. 2024

Front. Nutr.

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Thymus serpyllum L. (Lamiaceae), known in English as ‘wild thyme’, is primarily found in the Palearctic realm (Eurasia, North Africa) and has been utilized traditionally for culinary, nutritional, medicinal, and aromatic purposes. The essential oil extracted from wild thyme is particularly noteworthy, being used extensively in the food industry as a flavoring agent and preservative. The plant’s aerial parts are commonly employed as an element of the diet (e.g., tea)/for culinary uses and in local/traditional medicine (primarily for managing respiratory and gastrointestinal conditions), similar to the use of common thyme. There is practically no information available on the species’ nutritional benefits. Pharmacological studies, including in vitro and in vivo research, alongside a limited number of clinical trials, have investigated extracts of Thymus serpyllum, although these extracts are often phytochemically poorly characterized in different experimental protocols and models. These studies have demonstrated a range of therapeutic effects, such as antimicrobial (notably the essential oil) and anti-inflammatory, as well as its preventative health benefits and nutritional value of wild thyme. Preclinical studies have corroborated the plant’s anti-inflammatory potential, particularly in conditions like inflammatory bowel diseases (IBD) and irritable bowel syndromes (IBS). Additionally, evidence of hepatoprotective activities and benefits in managing metabolic syndrome and cardiovascular health issues, such as lipid metabolism regulation, cholesterol reduction, antidiabetic, antihypertensive, and immunomodulatory effects, have been observed predominantly in rodent models. Phytochemical analysis of wild thyme reveals an essential oil fraction below 1%, along with non-volatile compounds predominantly comprising phenolic acids (such as rosmarinic, salvianolic, and caffeic acids) and flavonoids (mainly glucosides of luteolin, apigenin, and their derivatives). These components are believed to contribute significantly to the plant’s medicinal, nutritional, and preventive health properties. Despite promising findings, there is a need for more rigorously designed controlled clinical trials using phytochemically characterized wild thyme. The plant has an excellent safety and tolerability record. This review at the interface of nutritional/preventive health properties and as pharmacological activities highlights the current role of wild thyme in nutrition and general healthcare as well as its future potential, and also points to important gaps in the literature.

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Section: Resultsmentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

Wild thyme (Thymus serpyllum L.): a review of the current evidence of nutritional and preventive health benefits*

Jalil,

Pischel,

Feistel

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…In addition, they can improve memory and cognitive functions, as well as provide gastrointestinal protection. These natural components also possess potential biological activities by exhibiting anti-inflammatory, analgesic, antineoplastic, antiosteoporotic and antimicrobial properties [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Biological Profile and Allergenicity of Thymus baicalensis Plant of Mongolian Origin

et al. 2021

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Thymus baicalensis is a medicinal plant recognized as a traditional Mongolian therapeutic and health-promoting food supplement. The aim of the study was to check the suitability of the tested plant for supporting the treatment of certain diseases. The following study is the first one to showcase the versatile scope of characteristics of T. baicalensis, including its volatile oil composition, polyphenolic composition, lipid composition, phenolic and flavonoid contents, antioxidant activity, antimicrobial properties and ingestive allergenicity. Myrcene, at 26.15%, was shown to be the most abundant component of the volatile oil. Compounds known as inherent components of the Thymus genus: thymol and carvacrol made up only about 0.24% of the extracted oil. As much as 10.11 g kg−1 of polyphenol compounds were identified as derivatives of luteolin-7-O-glucuronide. The lipid extract was found to be rich in palmitic acid (31.05%), while unsaturated fatty acids were not reported. Spectrophotometric determination of the phenols and flavonoids indicated 7.541 mg of gallic acid g−1 and 4.345 mg of quercitin g−1, respectively. The free radical scavenging activity was determined by the 2,2-difenylo-1-pikrylohydrazyl method at IC50 = 206.97 µg mL−1. The extracts also had a strong inhibitory effect on M. flavus and P. fluorescenes bacteria, as well as S. cerevisiae yeasts. The Bet v 1 and profilin allergens in T. baicalensis were reported at 175.17 ng g−1 and 1.66 ng g−1, respectively.

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Antimicrobial Activity and Polyphenol Profiles of Hydroalcoholic Extracts of Thymus rasitatus Klokov and Thymus eremita Klokov

Cited by 2 publications

References 8 publications

Wild thyme (Thymus serpyllum L.): a review of the current evidence of nutritional and preventive health benefits*

Wild thyme (Thymus serpyllum L.): a review of the current evidence of nutritional and preventive health benefits*

Chemical and Biological Profile and Allergenicity of Thymus baicalensis Plant of Mongolian Origin

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