Antimicrobial activity and phenolic composition of varieties of
            <i>Hibiscus sabdariffa</i>
            L. with red and white calyces

Salinas-Moreno, Y.; Arteaga-Garibay, Ramón Ignacio; Arroyo-Silva, Anita; Ordaz-Ortíz, José Juan; Ruvalcaba-Gómez, José Martín; Gálvez-Marroquín, Luis Antonio

doi:10.1080/19476337.2022.2152099

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…The aqueous extract of roselle flowers contains several flavonoid compounds and phenolic acids (Da-Costa-Rocha et al, 2014) which are known to inhibit the growth of S. aureus bacteria, including: quercetin-3-glycoside and kaempferol-3glycoside with MIC 0.065 mg/mL (Lade et al, 2022) , mirisetin with MIC 0.005 mg/mL (Rashed et al, 2014;Salinas-Moreno et al, 2023) and chlorogenic acid with MIC 40 𝜇g/mL (Abdel-Shafi et al, 2019) . In addition, quercetin and protocatechuic acid (5 mg/mL) can inhibit the growth of MRSA strains with MIC of 62.5 mg/mL and 24-44 𝜇g/mL (Lee et al, 2018;Woźnicka et al, 2013) .…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking of Flavonoids from Extract of Roselle (Hibiscus sabdariffa L.) Calyx on PBP2a as the Basis for Antibacterial Activity Against Methicillin Resistant Staphylococcus aureus

Ramadhani,

Prastika,

Fikriyah

et al. 2024

Sci. Technol. Indones

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The increasing bacterial resistances to antibiotics are serious threat to world health. In Indonesia, there are resistant bacteria such as Methicillin Resistant Staphylococcus aureus (MRSA). In order to overcome the problem, the compounds contained in the Hibiscus sabdariffa L. are potential to be developed as new antibacterial against MRSA. To confirm the antibacterial activity, the extract of roselle calyx was tested against MRSA. The twelve compounds contained in the extract was docked into binding site of PBP2a using Autodock 4.2.6. The results showed MIC 2.5% of roselle extract. Two flavonoid compounds comply the Lipinski’s rules and the docking results showed all compounds had higher binding affinity than reference ligand ceftobiprole. The quantitative structure-physicochemical property relationship (QSPR) found that steric property (CMR) and energy (Etotal) of ligand contributed to the binding affinity against PBP2a. It concluded kaempferol-rutinoside was the most potential compound from H. sabdariffa that could be selected as lead compound to be develop as antibacterial agents.

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