2021
DOI: 10.1016/j.micres.2020.126652
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Antimicrobial activity and biosynthetic potential of cultivable actinomycetes associated with Lichen symbiosis from Qinghai-Tibet Plateau

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Cited by 25 publications
(23 citation statements)
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“…strains showed high antimicrobial activity were inoculated into 50 ml of ISP2 medium without Agar and subjected to constant agitation for 5–7 days until the turbidity of the medium was high. Cells were concentrated by centrifugation at 10,000 g for 20 min at 4 °C, and then congealed (without supernatant) in 2 mL eppendorfs tubes at − 20 °C until used 86 . DNA extraction was performed by an automated system (Mag Purix Bacterial DNA Extraction Kit) following the manufacturer's instructions.…”
Section: Methodsmentioning
confidence: 99%
“…strains showed high antimicrobial activity were inoculated into 50 ml of ISP2 medium without Agar and subjected to constant agitation for 5–7 days until the turbidity of the medium was high. Cells were concentrated by centrifugation at 10,000 g for 20 min at 4 °C, and then congealed (without supernatant) in 2 mL eppendorfs tubes at − 20 °C until used 86 . DNA extraction was performed by an automated system (Mag Purix Bacterial DNA Extraction Kit) following the manufacturer's instructions.…”
Section: Methodsmentioning
confidence: 99%
“…Their broad spectrum of activity suggests potential for the development of a therapeutic strategy to control antimicrobial resistance. In a recent study, some natural compounds belonging to pyrrolidine, anthracyclines, and indole derivatives identified from the actinobacteria, Streptomyces , were shown to have inhibitory activity on HIV-1 reverse transcriptase, indicating that actinobacteria are promising sources of biological active metabolites, which could provide important bioactive compounds as potential antibiotic drugs (Hei et al 2021 ).…”
Section: Approaches To Combat Antimicrobial Resistance To Complement ...mentioning
confidence: 99%
“…They have also revealed that lichens are in fact better described as micro-communities with multiple additional components, such as basidiomycete yeasts and other bacteria, mainly Proteobacteria and Actinobacteria [ 299 , 300 , 301 ]. Lichens are widespread in nature and can be found in multiple habitats, including extreme environments [ 302 , 303 ], and it is thought the mycobiont offers structural support and protection against abiotic stress, whereas the photobiont offers nutrient acquisition through photosynthesis and nitrogen fixation [ 299 ].…”
Section: Lichensmentioning
confidence: 99%
“…These observations, alongside other untargeted metabolomics’ studies on lichens strongly suggest that some secondary metabolites can be specific to symbiotic relationships and that exploring these niches can expand the chemical diversity of this kind of metabolites [ 296 , 320 ]. This is true not only of lichens or their main components, as further work on lichen-like symbioses [ 321 ] or other lichen associated microorganisms, mainly Actinobacteria [ 303 , 304 , 322 ], has revealed rich, secondary metabolite-driven interactions [ 323 ] and promising leads for clinical use such as the enedine antibiotic uncialamycin ( Figure 13 ).…”
Section: Lichensmentioning
confidence: 99%