Antimicrobial Activities of Unconventional Compounds against Some Bacteria Associated with Skin Infections in Humans, Sheep and Goats

Abstract

Bacterial skin infections are a common problem encountered in clinical practice and causing great economic losses for sheep and goats producers. Increasing multidrug resistance of pathogens paves the way for reconsidering alternative medicine. The present study was carried out to explore the antibacterial activities of different volumes; 5, 25, 50 and 100 µL of gold nanoparticles (NPS) and the aqueous and ethanolic extracts of garlic, turmeric and cinnamon at different concentrations (20, 40, 80 and 100%) against molecularly confirmed Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli isolated from skin pyogenic lesions in humans, sheep and goats using disc diffusion assay. The results compared with ciprofloxacin (5 µg mL −1). Gold nanoparticles (NPS) 100 µL were highly effective against Pseudomonas aeruginosa and Escherichia coli in comparing with ciprofloxacin (5 µg mL −1 ). Garlic has shown better activity against Staphylococcus aureus and Streptococcus pyogenes in aqueous solution while the ethanolic extract of cinnamon and turmeric was more efficient than the aqueous extract. Among the three tested spices, turmeric was the least effective against tested bacteria. The proven activity of 100 µL Gold nanoparticles (NPS) and 100% aqueous garlic extract compared with ciprofloxacin (5 µg mL −1 ), suggests their use in clinical trials as an alternative medicine to reduce the side effects and progressively increasing drug resistance of pathogens.

Effect of plants extracts on the growth of Candida albicans and Staphylococcus aureus

“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License in the same, their antimicrobial and antifungal effect has been tested and their effect has been compared with the standard antibiotics (Sakagami et al, 2001;Velickovic et al, 2003). Many researchers in the field of natural antibiotics for microbiology have indicated the importance of using the plant extracts distinguished with the ease of obtaining the same and its low side-effects in comparison with the synthetic antibiotics (Adel and Mahasneh, 1999;De-Boer et al, 2005;Shabana and El-Adly, 2016). Egyimann et al (2003) have stated that during the last ten years, the infections resulted from C. albicans and systemic infections resulting from the same especially among the immunodeficiency patients.…”