Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes

Tagousop, Cyrille Ngoufack; Tamokou, Jean-De-Dieu; Kengne, Iréne Chinda; Ngnokam, David; Voutquenne-Nazabadioko, Laurence

doi:10.1186/s13065-018-0466-6

Cited by 64 publications

(41 citation statements)

References 29 publications

(30 reference statements)

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“…21,22 Oleanolic acid has also exhibited anti-tubercular activity. 23 The derivatives of oleanolic acid have been reported for the treatment of pancreatic cancer, 24 and oleanolic acid saponins have shown significant antimicrobial properties, 25 and the combination of oleanolic acid with hypocrellin A has been reported for the treatment of hepatocellular carcinoma diseases, 26 and oleanolic acid derivative SZC014 has exhibited anticancer activity. 27 Oleanolic acid has shown antidiabetic, 28,29 and hepatoprotective activities, 30,31 which may establish the use of H. umbellata as antidiabetic by the local inhabitants in Nigeria.…”

Section: Resultsmentioning

confidence: 99%

Isolation of Phytochemical Constituents from Hunteria umbellata K. Schum

Ali¹,

Falodun²,

Siyo³

et al. 2019

TJNPR

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Hunteria umbellata K. Schum has been reported for the treatment of diabetes in Nigeria. In the present study, the ethanolic extract of dried leaves of Hunteria umbellata K. Schum was investigated for the chemical principles. The isolated pure compounds were characterized by NMR, IR and Mass spectral studies. Ursolic acid (1), oleanolic acid (2) and squalene (3) were the main constituents isolated from the extract.

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Section: Resultsmentioning

confidence: 99%

Isolation of Phytochemical Constituents from Hunteria umbellata K. Schum

Ali¹,

Falodun²,

Siyo³

et al. 2019

TJNPR

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Untitled

2019

TJNPR

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3(3):95-98 ISSN 2616-0684 (Print) ISSN 2616-0692 (Electronic) 95Hunteria umbellata K. Schum has been reported for the treatment of diabetes in Nigeria. In the present study, the ethanolic extract of dried leaves of Hunteria umbellata K. Schum was investigated for the chemical principles. The isolated pure compounds were characterized by NMR, IR and Mass spectral studies. Ursolic acid (1), oleanolic acid (2) and squalene (3) were the main constituents isolated from the extract.

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“…These compounds represent an alternative to overcome multidrug-resistant microorganisms since they can act synergistically with antibiotics. Moreover, medicines that were once considered ineffective due to resistance problems might be effective for resistant microbes [122,123]. Nevertheless, as reported by [124], saponin from Quillaja saponaria bark did not present synergistic activity in combination with ampicillin, streptomycin, and ciprofloxacin against a clinical strain of E. coli.…”

Section: Natural Products and Endophytic Fungimentioning

confidence: 90%

Plant-Associated Microorganisms as a Potent Bio-Factory of Active Molecules against Multiresistant Pathogens

Cruz¹,

Bogas²,

Sousa³

2021

Antimicrobial Resistance - A One Health Perspective

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Antibiotic-resistant pathogens are a public health threat that has rapidly spread over decades due to continuous and uncontrolled administration of antimicrobial medicines, becoming an ever-increasing worldwide concern. Since the past decade, no significant innovations have been made, so the search for new compounds that face multidrug-resistant pathogens is critically important. Plant-symbiont microorganisms are capable of producing a variety of bioactive natural products, making it possible to treat several infectious diseases. Biotechnological processes using microorganisms have been increasing in recent years since the discovery of Paclitaxel, an important antimitotic produced by the endophyte Taxomyces andreanae. It was isolated for the first time from the native tree of Pacific Taxus brevifolia. Several studies have demonstrated the isolation and characterization of promising and potent substances capable of inhibiting these pathogens. In addition, both rhizospheric and endophytic communities represent an unexplored reserve of unique chemical structures for drug development. This chapter focuses on the potential of plant-derived microorganisms as a source of bioactive substances and the perspectives for further studies and their application.

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Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes

Cited by 64 publications

References 29 publications

Isolation of Phytochemical Constituents from Hunteria umbellata K. Schum

Isolation of Phytochemical Constituents from Hunteria umbellata K. Schum

Untitled

Plant-Associated Microorganisms as a Potent Bio-Factory of Active Molecules against Multiresistant Pathogens

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