Antimicrobial activities of methanol extract and compounds from stem bark of Vismia rubescens

Tamokou, Jean-De-Dieu; Tala, Michel Feussi; Wabo, Hippolyte K.; Kuiaté, Jules Roger; Tane, Pierre

doi:10.1016/j.jep.2009.04.062

Cited by 123 publications

(90 citation statements)

References 19 publications

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“…However, this compound from the stem bark of Vismia rubescens has been found to exhibit both antibacterial and antifungal activities (Tamokou et al, 2009). The antitumor activity could essentially be due to the presence of anticancer compounds such as morelloflavone or 7′-O-glucoside of morelloflavone.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark ofAllanblackia floribunda

Kuete

Azebaze

Mbaveng

et al. 2010

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark ofAllanblackia floribunda

Kuete

Azebaze

Mbaveng

et al. 2010

Pharmaceutical Biology

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“…In extending investigations on the berry constituents it was found that the hot chloroform and petroleum ether extracts of V. baccifera yielded α-copaene (112), l-α-curcumene (113), β-eudesmene (114), and β-curcumene (115) (Ferrari et al, 1978). Tamokou et al (2009) investigated the methanol extract of V. rubescens Oliv. and described the isolation of five compounds, viz., 1,4,8-trihydroxyxanthone (116), 1,7-dihydroxyxanthone (117), physcion (118), friedelin (119) and friedelanol (120) (Figure 10).…”

Section: (Figure 2)mentioning

confidence: 99%

Chemistry and biology of genusVismia

Hussain

Al‐Harrasi

Saleem

et al. 2012

Pharmaceutical Biology

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“…The results of MIC and MBC showed that the MIC values obtained were four times equal to or lesser than the MBCs on the corresponding (sensitive) bacteria, suggesting the bactericidal effects of the concerned samples. 27,28,29 This is interesting in view of the perspective of developing new antibacterial drugs from endophytic fungus. The present study showed antibacterial activity of penialidin A-C (1-3), citromycetin (4), p-hydroxyphenylglyoxalaldoxime (5) and brefelfin A (6) from Penicillium sp.…”

Section: Discussionmentioning

confidence: 99%

Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria

Jouda¹,

Tamokou²,

Mbazoa³

et al. 2016

Afr H. Sci.

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Background: The emergence of multiple-drug resistance bacteria has become a major threat and thus calls for an urgent need to search for new effective and safe anti-bacterial agents. Objectives: This study aims to evaluate the anticancer and antibacterial activities of secondary metabolites from Penicillium sp., an endophytic fungus associated with leaves of Garcinia nobilis. Methods: The culture filtrate from the fermentation of Penicillium sp. was extracted and analyzed by liquid chromatographymass spectrometry, and the major metabolites were isolated and identified by spectroscopic analyses and by comparison with published data. The antibacterial activity of the compounds was assessed by broth microdilution method while the anticancer activity was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: The fractionation of the crude extract afforded penialidin A-C (1-3), citromycetin (4), p-hydroxyphenylglyoxalaldoxime (5) and brefelfin A (6). All of the compounds tested here showed antibacterial activity (MIC = 0.50 -128 µg/mL) against Gramnegative multi-drug resistance bacteria, Vibrio cholerae (causative agent of dreadful disease cholera) and Shigella flexneri (causative agent of shigellosis), as well as the significant anticancer activity (LC 50 = 0.88 -9.21 µg/mL) against HeLa cells. Conclusion:The results obtained indicate that compounds 1-6 showed good antibacterial and anticancer activities with no toxicity to human red blood cells and normal Vero cells.

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Antimicrobial activities of methanol extract and compounds from stem bark of Vismia rubescens

Cited by 123 publications

References 19 publications

Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark ofAllanblackia floribunda

Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark ofAllanblackia floribunda

Chemistry and biology of genusVismia

Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria

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