Antimicrobial acrylic materials with <i>in situ</i> generated silver nanoparticles

Oei, James D.; Zhao, Wen; Chu, Lianrui; DeSilva, Mauris N.; Ghimire, Abishek; Rawls, H. Ralph; Whang, Kyumin

doi:10.1002/jbm.b.31963

Cited by 94 publications

(82 citation statements)

References 32 publications

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“…The varied and broad spectrum activity of NanoAg in vitro has been reported before. 41 Based on results of the present study, the strong antimicrobial activity of NanoAg-IS-BOA in comparison to NanoAg-I-BOA and PMMA, regarding other studies which have shown considering non-detrimental effects of NanoAg-IS-BOA on mechanical properties of acrylic, 22,34 it seems clinically advantageous to use NanoAg-IS-BOA and benefit their antimicrobial properties. However, further studies are needed to evaluate the proper concentrations for final products.…”

supporting

confidence: 64%

“…This NanoAg-IS-PMMA showed excellent antimicrobial properties against planktonic bacterial cells growth of A. bumannii, P. aeruginosa, P. mirabilis, S. aureus and S. mutans. 34 Our data demonstrated the NanoAg-IS-BOA exhibited a high antimicrobial efficacy, even if the content of silver nanoparticles in NanoAg-IS-BOA is as low as 0.5% w/w all test bacteria in saliva are inhibited over 53.2 to 98.4% within 4 weeks. This low amount of NanoAg does not have any adverse effect on the mechanical properties of the polymer.…”

Section: Flow Chartmentioning

confidence: 56%

“…Another study in this series showed the effectiveness of NanoAg-IS-PMMA on the A. bumannii, P. aeruginosa, P. mirabilis and S. aureus. 34 In the present study, we tested the efficiency of NanoAg in situ in baseplates of orthodontic appliances (NanoAg-IS-BOA) and BOA incorporated with NanoAg (NanoAg-I-BOA) in reducing planktonic and biofilm load of S. mutans, S. sobrinus, L. acidophilus as well as L. casei, as cariogenic agents in randomized controlled clinical trials. Our results showed that 4 weeks wearing of NanoAg-IS-BOA and NanoAg-I-BOA reduced significantly the planktonic levels of test bacteria in saliva compared to baseline levels.…”

Section: Flow Chartmentioning

confidence: 99%

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Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Doubleblind Cross-over Clinical Trial

Ghorbanzadeh¹,

Pourakbari²,

Bahador³

2015

The Journal of Contemporary Dental Practice

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Aim Polymethyl-methacrylate (PMMA) is commonly used primarily for baseplates of orthodontic appliances (BOA). The activities of cariogenic bacteria in biofilm on these surfaces may contribute to dental caries, gingival inflammation and periodontal disease. The PMMA incorporated with nanoparticles of silver (NanoAg-I-PMMA) and NanoAg in situ in PMMA (NanoAg-IS-PMMA) have been shown to control the growth of cariogenic bacteria, but clinical trial of anti-cariogenic application of these novel materials in orthodontics has not been evaluated. The main aim of the study is to compare the clinical effectiveness of using NanoAg-IS-PMMA and NanoAg-I-PMMA for construction of new BOA in inhibiting the planktonic growth and biofilm formation of the cariogenic bacteria. Materials and methods Twenty four patients with a median age of 12.6 years (7-15) harboring Streptococcus mutans, Streptococcus sobrinus and Lactobacillus acidophilus as well as Lactobacillus casei participated in the randomized, doubleblind, cross-over study. The experimental BOA, NanoAg-ISBOA and NanoAg-I-BOA, contained 0.5% w/w NanoAg while the control BOA was standard PMMA. Antibacterial effect of NanoAg-IS-BOA and NanoAg-I-BOA was assessed against test cariogenic bacteria by planktonic and biofilm bacterial cells growth inhibition. Results The average levels of test cariogenic bacteria in saliva decreased about 2 to 70 fold (30.9-98.4%) compared to baseline depending on the microorganism type and test BOA. Biofilm inhibition analysis demonstrated that NanoAg-I-BOA and NanoAg-IS-BOA inhibited the biofilm of all test bacteria by 20.1 to 79.9% compared to BOA. NanoAg-IS-BOA had a strong anti-biofilm effect against S. mutans, S. sobrinus and L. casei. However, NanoAg-I-BOA showed only slight antibiofilm effects on test bacteria. Most notably, at all period of the clinical trial, NanoAg-IS-BOA showed a higher antibacterial activity than NanoAg-I-BOA. Conclusion Based on the novel data that presented here, the NanoAg-IS-BOA had strong antimicrobial activity in the planktonic phase and subsequent biofilm formation of the cariogenic bacteria. Clinical significance Wearing of NanoAg-IS-BOA has the potential to minimize dental plaque formation and caries during orthodontic treatment. How to cite this article Ghorbanzadeh R, Pourakbari B, Bahador A. Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Double-blind Cross-over Clinical Trial. J Contemp Dent Pract 2015;16(4):291-298.

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supporting

confidence: 64%

Section: Flow Chartmentioning

confidence: 56%

Section: Flow Chartmentioning

confidence: 99%

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Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Doubleblind Cross-over Clinical Trial

Ghorbanzadeh¹,

Pourakbari²,

Bahador³

2015

The Journal of Contemporary Dental Practice

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“…Silver nanoparticles are well known as one of the most universal antimicrobial substances in the field of biology and medicine due to their strong biocidal effect against microbial species, which has been used for centuries to prevent and treat various diseases, most notably infections. 14 Silver nanoparticles also reported to possess anti-fungal, 15 anti-inflammatory, 16 anti-viral, 17 anti-angiogenesis 18 and anti-platelet activity. 19 Recently, the development of silver nanoparticles is expanding.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of silver nanoparticles by using tea leaf extract from Camellia Sinensis

Loo¹,

Chieng²,

Nishibuchi³

et al. 2012

IJN

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Abstract:The development of the biological synthesis of nanoparticles using microorganisms or plant extracts plays an important role in the field of nanotechnology as it is environmentally friendly and does not involve any harmful chemicals. In this study, the synthesis of silver nanoparticles using the leaves extract of Chinese tea from Camellia sinensis is reported. The synthesized nanoparticles were characterized using UV-vis spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy. The XRD analysis shows that the synthesized silver nanoparticles are of facecentered cubic structure. Well-dispersed silver nanoparticles with an approximate size of 4 nm were observed in the TEM image. The application of the green synthesized nanoparticles can be used in many fields such as cosmetics, foods, and medicine.

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“…59,65 Noble metals Silver (Ag) Several studies found that addition of silver NPs (AgNPs) to denture base acrylic resin displayed antifungal properties, [66][67][68][69] especially at high concentrations, 70 and acted like a latent antifungal material with low-releasing Ag + . 71 On the contrary, Wady et al 72 found that incorporating silver NPs in PMMA did not affect the adhesion of C. albicans and biofilm accumulation.…”

mentioning

confidence: 98%

PMMA denture base material enhancement: a review of fiber, filler, and nanofiller addition

Gad

Fouda

Al‐Harbi

et al. 2017

IJN

309

319

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This paper reviews acrylic denture base resin enhancement during the past few decades. Specific attention is given to the effect of fiber, filler, and nanofiller addition on poly(methyl methacrylate) (PMMA) properties. The review is based on scientific reviews, papers, and abstracts, as well as studies concerning the effect of additives, fibers, fillers, and reinforcement materials on PMMA, published between 1974 and 2016. Many studies have reported improvement of PMMA denture base material with the addition of fillers, fibers, nanofiller, and hybrid reinforcement. However, most of the studies were limited to in vitro investigations without bioactivity and clinical implications. Considering the findings of the review, there is no ideal denture base material, but the properties of PMMA could be improved with some modifications, especially with silanized nanoparticle addition and a hybrid reinforcement system.

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Antimicrobial acrylic materials with in situ generated silver nanoparticles

Abstract: AgNP-PMMA demonstrated a tremendously broad-spectrum and long-intermediate-term antimicrobial effect with comparable mechanical properties to control PMMA. Current efforts are focused on further improving mechanical properties by reducing AgNP loading and assessing fatigue properties.

Cited by 94 publications

References 32 publications

Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Doubleblind Cross-over Clinical Trial

Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Doubleblind Cross-over Clinical Trial

Synthesis of silver nanoparticles by using tea leaf extract from Camellia Sinensis

PMMA denture base material enhancement: a review of fiber, filler, and nanofiller addition

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