Antimethicillin-resistant Staphylococcus aureus and Biological Activities of Metabolites from Digitaria Sanguinalis L.

Abstract

is one of the largest vascular plant families, containing between 650 and 785 genera and 10 000 species. Poaceae is also one of the most ecologically and economically important plant families [1]. Some Poaceae plants are used in folk medicine as antihypertensive, antidiabetic, antiinflammatory, anthelmintic, astringent, antiulcer, diuretic and antioxidant agents [2]. This family is of great economic and medicinal importance as it includes all cereals, bamboos and sugar cane. Steroids, terpenoids, volatile oils, saponins, flavonoids, phenolic acids, fatty acids, hydroxamic acids and alkaloids are the main classes of phytoconstituents in Poaceae [3]. Digitaria belongs to Poaceae family and is found in Egypt as three species under the local name Dafraa [4]. One of the main causes of hospital-related mortality and morbidity is pathogenic bacterial infection [5]. The pathogen Staphylococcus aureus often colonizes the skin surface, the upper respiratory tract, and the nasal tract [6]. S. aureus accounts for high mortality rates in patients with pneumonia, endocarditis, sepsis and urinary tract infections [7]. Methicillin has been used to treat S. aureus infections since the 1950s. Tragically, S. aureus acquired resistance towards methicillin after several years [8]. Methicillin is a β-lactam antimicrobial that alters the penicillin-binding proteins required for blending of the peptidoglycans of S. aureus [9]. The occurrence of the MecA gene that encodes for PBP2a were utilized as benchmarks to identify the proximity of methicillin resistant S. aureus (MRSA) [10]. The

In vivo determination of analgesic and anti-inflammatory activities of isolated compounds from Cleome amblyocarpa and molecular modelling for the top active investigated compounds

“…Compound 2 : Pale white powder; R f = 0.43 (90 : 10 CHCl 3 /MeOH); MP = 283 °C; it was identified as β-sitosterol 3- O -β- d -glucoside (Fig. 1) by comparing 1 H-NMR (400 MHz; DMSO- d 6 ) and 13 C-NMR (100 MHz; DMSO- d 6 ) analyses with the spectral published data, 35 see (Table S.2†).…”

Phytochemical Screening, Toxic Effects, and Antimicrobial Activity Studies of Digitaria abyssinica (Hochst. ex A.Rich.) Stapf (Poaceae) Rhizome Extracts against Selected Uropathogenic Microorganisms

“…Also, toxic effects and antimicrobial activity studies have not been reported in the literature. However, reports exist for several plants from the Digitaria genus that possesses active phytochemicals with antimicrobial activities and other varied biological activities including analgesic, antiviral, anti-inflammatory, antitumor, anthelmintic action, and effects on the central nervous system [ 49 , 50 ].…”

“…Also, toxic efects and antimicrobial activity studies have not been reported in the literature. However, reports exist for several plants from the Digitaria genus that possesses active phytochemicals with antimicrobial activities and other varied biological activities including analgesic, antiviral, anti-infammatory, antitumor, anthelmintic action, and effects on the central nervous system [49,50]. All female Wistar rats in this study, survived after administration of a single dose of 2000 mg/kg of the aqueous, methanol, and dichloromethane : methanol (1 : 1) extracts of D. abyssinica to the Wistar rats orally.…”

Antimicrobial Activity against Foodborne Pathogens and Antioxidant Activity of Plant Leaves Traditionally Used as Food Packaging

“…Isoorientin ( II ) is a flavonoid glycoside found in many plants, such as Rhapis excelsa in the Arecaceae family [ 47 ], Stellaria nemorum , and Stellaria holostea in the Caryophyllaceae family [ 48 ]. Previous studies also reported various biological activities of isoorientin, such as anti-inflammatory [ 49 ], antioxidant, and antibiotic activities [ 50 ]. Isovitexin ( III ) has been isolated from some plants such as the aerial part of Lythrum salicaria [ 51 ] and the leaves of Gentiana spp.…”