Antimelanogenic Effect of Ligularia fischeri, Solidago virga-aurea, Aruncus dioicus Extracts from Ullung Island in Murine Melanoma Cells

김동희,; 안봉전,; 김세기,; 박태순,; 박근혜,; 손준호,

doi:10.5352/jls.2011.21.2.279

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…Western blot analysis of MITF, TRP-1, TRP-2, and tyrosinase measured following the method described by Kim et al (2011). The medium containing B16F10 melanoma cells was added with phosvitin in deionized distilled water at a concentration of 5, 10, and 50 lg/ml, followed by 48 h incubation.…”

Section: Western Blot Analysismentioning

confidence: 99%

The functional property of egg yolk phosvitin as a melanogenesis inhibitor

et al. 2012

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Section: Western Blot Analysismentioning

confidence: 99%

The functional property of egg yolk phosvitin as a melanogenesis inhibitor

et al. 2012

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“…특히 해조류인 감태, 곰피, 미역 등 [6,12,19]의 melanin 합성과정과 tyrosinase 저해효과에 대한 연구와 곰취, 미역취 등의 복합 추출물 [11], 조릿대 [24] 등 약용작물의 미백 효과에 대한 연구가 보고되고 있다.…”

Section: 서 론unclassified

Effects of Hizikia fusiforme Fractions on Melanin Synthesis in B16F10 Melanoma Cells

최은옥¹,

김향숙²,

한민호³

et al. 2013

Journal of Life Science

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The objective of this study was to evaluate the anti-melanogenic effects of Hizikia fusiforme (HF) fractions in α-melanocyte stimulating hormone-induced B16F10 mouse melanoma cells. Ethanol extractions of Hizikia fusiforme (EEHF) were subjected to fraction by using dichloromethane (CFHF), ethyl acetate (EAFHF), butanol (BFHF), and water (WFHF). EEHF, CFHF, and EAFHF inhibited tyrosinase activity and melanin synthesis in B16F10 mouse melanoma cells in a dose-dependent manner. The melanin contents were inhibited by 40.5% and 33.2% in response to treatment with 50 μg/ml of EEHF and CFHF, respectively. In addition, tyrosinase activities showed a 53.3% and 54.1% reduction in treatment with 50 μg/ml of EEHF and CFHF. Western blotting analysis showed that EEHF, CFHF, and EAFHF inhibited tyrosinase, TRP-1, TRP-2, and MITF expression in a dose-dependent manner. In conclusion, these findings indicate that ethanol and dichloromethane fractions of Hizikia fusiforme, which inhibit melanin synthesis and tyrosinase activity, are effective skin-whitening agents.Key words : Hizikia fusiforme, melanogenesis, tyrosinase *Corresponding author *Tel : +82-51-890-1594, Fax : +82-51-890-2646 *E-mail : hhj2001@deu.ac.kr This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…are sold at local markets in Korea ( Table 1 ). The extracts and compounds obtained from traditional GLVs (1–18) have been shown to possess antioxidant [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ], anticancer [ 18 , 23 , 24 , 25 , 26 ], antiinflammation [ 20 , 25 , 27 , 28 ], anti-melanogenic [ 29 , 30 ], anti-fatigue [ 31 ], anti-obesity [ 32 , 33 ], antidiabetic [ 34 ], and immunostimulatory [ 35 ] activities. GLVs have abundant phytopigments.…”

Section: Introductionmentioning

confidence: 99%

Carotenoid and Tocopherol Profiling in 18 Korean Traditional Green Leafy Vegetables by LC-SIM-MS

Lee

Sivanesan

et al. 2023

Foods

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Fruits and vegetables are a vital source of redox-active phytochemicals in the diet. Traditional green leafy vegetables (GLVs) are a rich source of carotenoids, dietary fiber, minerals, phenols, vitamins, and tocopherols and are commonly consumed in rural areas worldwide. In traditional Korean medicine, many GLVs are used to treat various ailments. However, data on the carotenoid and tocopherol content of many traditional GLVs consumed in the Republic of Korea are insufficient. The current work aims to compare the carotenoid and tocopherol profiles of 18 traditional GLVs by utilizing a single ion monitoring LC-MS approach to identify the potential GLVs for commercial cultivation and healthy diet formulations. Among the traditional GLVs investigated, (all-E)-lutein was the most abundant carotenoid, ranging from 44.4% in Glehnia littoralis to 52.1% in Heracleum moellendorffii. It was followed by (all-E)-violaxanthin and (all-E)-β-carotene. The highest contents of (all-E)-violaxanthin (75.6 µg/g FW), 9-Z-neoxanthin (48.4 µg/g FW), (all-E)-luteoxanthin (10.8 µg/g FW), (all-E)-lutein (174.1 µg/g FW), total xanthophylls (310.5 µg/g FW), (all-E)-β-carotene (69.6 µg/g FW), and total carotenoids (380.1 µg/g FW) were recorded in Pimpinella brachycarpa. Surprisingly, Taraxacum mongolicum also showed the highest contents of (all-E)-violaxanthin, (all-E)-lutein, and total carotenoids, which were statistically non-significant (p > 0.05, Tukey HSD) with P. brachycarpa. The highest concentration of (all-E)-zeaxanthin (14.4 µg/g FW) was recorded in Solidago virga-aurea. Among the studied herbs, 13.9 (H. moellendorffii)–133.6 µg/g FW (Toona sinensis) of α-tocopherol was recorded. Overall, the results suggest that P. brachycarpa and T. mongolicum are rich sources of carotenoids. On the other hand, T. sinensis is a rich source of α-tocopherol. These GLVs can be utilized in the diet to enhance the intake of health-beneficial carotenoids and α-tocopherol.

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Antimelanogenic Effect of Ligularia fischeri, Solidago virga-aurea, Aruncus dioicus Extracts from Ullung Island in Murine Melanoma Cells

Cited by 8 publications

References 7 publications

The functional property of egg yolk phosvitin as a melanogenesis inhibitor

The functional property of egg yolk phosvitin as a melanogenesis inhibitor

Effects of Hizikia fusiforme Fractions on Melanin Synthesis in B16F10 Melanoma Cells

Carotenoid and Tocopherol Profiling in 18 Korean Traditional Green Leafy Vegetables by LC-SIM-MS

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