Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels

Bächer, Christian; Kihm, Alexander; Schrack, Lukas; Kaestner, Lars; Laschke, Matthias W.; Wagner, Christian; Gekle, Stephan

doi:10.1016/j.bpj.2018.06.013

Cited by 29 publications

(34 citation statements)

References 100 publications

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“…Furthermore, in the Supplementary Information of ref. [82] we have shown red blood cell shapes for a single cell in tube flow and in a rectangular channel, respectively, that are in very good agreement with previous studies using dissipative particle dynamics [83] and boundary integral method [56], respectively. The stability and behavior of stiff particles realized by IBM has been shown and validated in ref.…”

Section: Validation Of Lbm/ibm For Passive Elastic Membranessupporting

confidence: 90%

“…Our implementation of the force calculation and the LBM/IBM have extensively been tested for passive, elastic membranes in previous publications [52,56,78,[80][81][82].…”

Section: Validation Of Lbm/ibm For Passive Elastic Membranesmentioning

confidence: 99%

“…The stability and behavior of stiff particles realized by IBM has been shown and validated in ref. [81] and [82] for a spherical particle based on the Stokes relation (sphere pulled through a quiescent fluid as well as a fixed sphere in homogeneous flow) and an ellipsoidal particle rotating in shear flow.…”

Section: Validation Of Lbm/ibm For Passive Elastic Membranesmentioning

confidence: 99%

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Computational modeling of active deformable membranes embedded in three-dimensional flows

Bächer

Gekle

2019

Phys. Rev. E

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Active gel theory has recently been very successful in describing biologically active materials such as actin filaments or moving bacteria in temporally fixed and simple geometries such as cubes or spheres. Here we develop a computational algorithm to compute the dynamic evolution of an arbitrarily shaped, deformable thin membrane of active material embedded in a 3D flowing liquid. For this, our algorithm combines active gel theory with the classical theory of thin elastic shells. To compute the actual forces resulting from active stresses, we apply a parabolic fitting procedure to the triangulated membrane surface. Active forces are then dynamically coupled via an Immersed-Boundary method to the surrounding fluid whose dynamics can be solved by any standard, e.g. Lattice-Boltzmann, flow solver. We validate our algorithm using the Green's functions of [Berthoumieux et al. New J. Phys. 16, 065005 (2014)] for an active cylindrical membrane subjected (i) to a locally increased active stress and (ii) to a homogeneous active stress. For the latter scenario, we predict in addition a so far unobserved non-axisymmetric instability. We highlight the versatility of our method by analyzing the flow field inside an actively deforming cell embedded in external shear flow. Further applications may be cytoplasmic streaming or active membranes in blood flows. Published as: Phys. Rev. E 99(6), 062418 (2019)

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Section: Validation Of Lbm/ibm For Passive Elastic Membranessupporting

confidence: 90%

“…Our implementation of the force calculation and the LBM/IBM have extensively been tested for passive, elastic membranes in previous publications [52,56,78,[80][81][82].…”

Section: Validation Of Lbm/ibm For Passive Elastic Membranesmentioning

confidence: 99%

Section: Validation Of Lbm/ibm For Passive Elastic Membranesmentioning

confidence: 99%

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Computational modeling of active deformable membranes embedded in three-dimensional flows

Bächer

Gekle

2019

Phys. Rev. E

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“…Finally, RBC aggregation can have an influence on the CFL [5]. Transverse migration also plays a role in the so-called margination effect: contrary to RBCs which are concentrated around the centerline, other blood elements like white cells or platelets are marginated against the wall [13][14][15][16][17][18][19], which helps them to accomplish their function (e.g. in immune response, inflammation...).…”

Section: Introductionmentioning

confidence: 99%

Migration velocity of red blood cells in microchannels

Losserand

Coupier

Podgorski

2019

Microvascular Research

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The lateral migration of red blood cells (RBCs) in confined channel flows is an important ingredient of microcirculatory hydrodynamics and is involved in the development of a cell free layer near vessel walls and influences the distribution of RBCs in networks. It is also relevant to a number of lab-on-chip applications. This migration is a consequence of their deformability and is due to the combined effects of hydrodynamic wall repulsion and the curvature of the fluid velocity profile. We performed microfluidic experiments with dilute suspensions of RBCs in which the trajectories and migration away from the channel wall are analyzed to extract the mean behavior, from which we propose a generic scaling law for the transverse migration velocity valid in a whole range of parameters relevant to microcirculatory and practical situations. Experiments with RBCs of different mechanical properties (separated by density gradient sedimentation or fixed with glutaraldehyde) show the influence of this parameter which can induce significant dispersion of the trajectories.

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“…This layer is known to contribute in the reduction of the blood viscosity or plasma skimming as blood perfuses the smaller vessels (Freund, 2014;Pries and Secomb, 2003). In addition, the migration of the red blood cells induces the margination of stiffer platelets by volume exclusion (Spann et al, 2016;Fitzgibbon et al, 2015;Reasor et al, 2013;Vahidkhah, 2015;Haga et al, 1998;Bächer et al, 2018). These marginated platelets are now better located to participate in reactions with the endothelial cells in the event of an injury when the clotting cascade begins (Mitrophanov et al, 2014;Govindarajan et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effect of Cytoplasmic Viscosity on Red Blood Cell Migration in Small Arteriole-level Confinements

Saadat

Guido

Shaqfeh³

2019

Preprint

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The dynamics of red blood cells in small arterioles are important as these dynamics affect many physiological processes such as hemostasis and thrombosis. However, studying red blood cell flows theoretically is challenging due to the complex shapes of red blood cells and the non-trivial viscosity contrast of a red blood cell. To date little progress has been made studying small arteriole flows (20-40µm) with a hematocrit (red blood cell volume fraction) of 10-20% and a physiological viscosity contrast. In this work, we present the results of large-scale simulations that show how the channel size, viscosity contrast of the red blood cells, and hematocrit effect cell distributions and the cell free layer in these systems. We utilize a massively-parallel immersed boundary code coupled to a finite volume solver to capture particle resolved physics in these systems. We show that channel size qualitatively changes how the cells distribute in the channel. Our results also indicate that at a hematocrit of 10% that the viscosity contrast is not negligible when calculating the cell free layer thickness. We explain this result by comparing lift and collision trajectories of cells at different viscosity contrasts.

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Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels

Cited by 29 publications

References 100 publications

Computational modeling of active deformable membranes embedded in three-dimensional flows

Computational modeling of active deformable membranes embedded in three-dimensional flows

Migration velocity of red blood cells in microchannels

Effect of Cytoplasmic Viscosity on Red Blood Cell Migration in Small Arteriole-level Confinements

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