Antimalarial therapy for granuloma annulare: Results of a retrospective analysis

Grewal, Sungat K.; Rubin, Courtney B.; Rosenbach, Misha

doi:10.1016/j.jaad.2016.11.044

Cited by 25 publications

(16 citation statements)

References 6 publications

(7 reference statements)

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“…In a 2017 retrospective cohort study, 10 of 18 patients (55.6%) treated for granuloma annulare with hydroxychloroquine improved with therapy . While localised granuloma annulare may respond to topical and intralesional therapy, widespread disease is more suited to treatment with antimalarials and phototherapy .…”

Section: Clinical Applications In Dermatologymentioning

confidence: 99%

Hydroxychloroquine in dermatology: New perspectives on an old drug

et al. 2019

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Hydroxychloroquine is an age-old drug whose use as an immunomodulatory agent with a low side-effect profile continues to expand. We present a review of this drug including recently updated prescribing recommendations and a summary of its clinical application in dermatology. A maximum daily dose of 5.0 mg/kg based on actual body weight and no greater than 400 mg is advised in order to reduce the risk of retinopathy, which is potentially permanent and has an estimated prevalence of 7.5% at 5 years on standard dosing. Baseline ophthalmologic assessment followed by annual screening after 5 years is recommended; however, closer monitoring should be considered in the setting of existing retinopathy, a cumulative dose > 1000 g or renal dysfunction. Hydroxychloroquine is now considered to be safe in pregnancy, and routine glucose-6-phosphate dehydrogenase (G6PD) deficiency testing is not required. Smoking can significantly decrease its efficacy although the reason is still uncertain. Hydroxychloroquine appears to also demonstrate antineoplastic and cardioprotective benefits.

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Section: Clinical Applications In Dermatologymentioning

confidence: 99%

Hydroxychloroquine in dermatology: New perspectives on an old drug

et al. 2019

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“…Fototerápia esetén leghatásosabbnak bizonyul a psoralen utáni UVA fénykezelés (PUVA kezelés), de a tünetek az esetek döntő többségében recidiválnak vagy csupán részlegesen regrediálnak. Antimaláriás szerek használata esetén, úgy mint a chloroquine 250 mg/nap dózisban, a betegek 100%-a válaszolt kielégítően a terápiára (15). Súlyos mellékhatások ellenére is (retinopátia, májkárosodás, aplasztikus anémia) elsőként választandó szisztémás szernek minősül GA terápiájában (24,25).…”

Section: Esetismertetésunclassified

Disseminated granuloma annulare in one case

Licskai¹,

Somogyi²,

Gyömörei³

et al. 2019

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ÖSSZEFOGLALÁSA granuloma anulare egy ismeretlen etiológiájú ritka bőrgyógyászati kórkép. A szerzők egy 51 éves nőbeteg esetét ismertetik, akinek mindkét lábszárán, kézfejek feszítő felszínén kiterjedten centrifugálisan terjedő anularis erythemas plakkokkal jelentkezett. Szövettani vizsgálat granuloma anulare diagnózisát állította fel. A beteg kivizsgálása során a gócés tumorkutatása negatív eredményt adott. Krónikus vírusinfekciót nem verifikáltak. Tünetei ezidő alatt az alkalmazott szisztémás és lokális kezelések ellenére fennálltak. Irodalmi adatok alapján, a további progresszió miatt a betegnél biológiai therápiát (TNF-alfa gátlót) indítottak. A szerzők jelen közleményükben összefoglalták a beteg esete kapcsán a granuloma anulare kezelési lehetőségeit.

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“…W piśmiennictwie są doniesienia o skuteczności leków antymalarycznych (chlorochiny i hydrochlorochiny) w leczeniu uogólnionego GA [6]. Do innych metod stosowanych w tym schorzeniu należą: preparaty glikokortykosteroidowe, pentoksyfilina, dapson, cyklosporyna, ogólne retinoidy, fototerapia, antybiotykoterapia, metotreksat, inhibitory TNF-a [7][8][9].…”

Section: Wprowadzenieunclassified

“…Publications regarding the use of antimalarial drugs in generalized GA appeared already 30 years ago [21,22]. In 2017 another retrospective study showing a successful treatment with chloroquine emerged [6]. The efficacy of chloroquine and hydroxychloroquine in GA is probably associated with inhibition of TNF-a production that contributes to degradation of extracellular matrix in the course of GA [23].…”

Section: References Piśmiennictwomentioning

confidence: 99%

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Generalized granuloma annulare

Dominiak¹,

Tomaszewska²,

Gerlicz-Kowalczuk³

et al. 2019

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Introduction. Granuloma annulare belongs to the category of dermatoses characterized by necrobiosis in histopathological examination. The disease concerns mainly people under 30 years old. There are different types of granuloma annulare: localized, generalized and subcutaneous. According to the latest scientific reports, antimalarial drugs take a significant place in the treatment of generalized granuloma annulare. Objective. To present a case of a patient with generalized granuloma annulare and concomitant clinical signs of necrobiosis lipoidica who was treated with chloroquine with substantial improvement. Case report. A 54-years-old patient hospitalized at the Dermatology Department because of annular and irregular erythematous-atrophic lesions on upper and lower limbs. Ulcerations were present within the lesions on lower extremities. Histopathology was indicative of granuloma annulare. Treatment with chloroquine resulted in marked improvement. Conclusions. Generalized types of granuloma annulare are rarely observed and constitute a therapeutic challenge. Antimalarial drugs may be considered as the first-line treatment in generalized granuloma annulare. sTrEsZcZENiE Wprowadzenie. Ziarniniak obrączkowaty należy do dermatoz charakteryzujących się nekrobiozą w badaniu histopatologicznym. Choroba dotyczy zazwyczaj osób poniżej 30. roku życia. Wyróżnia się odmiany: ograniczoną, uogólnioną i podskórną. Według nowych doniesień naukowych ważne miejsce w leczeniu uogólnionego ziarniniaka obrączkowatego zajmują leki antymalaryczne. Cel pracy. Przedstawienie przypadku pacjentki z uogólnionym ziarniniakiem obrączkowatym i ze zmianami na kończynach dolnych klinicznie wykazującymi podobieństwo do obumierania tłuszczowatego. Opis przypadku. Kobieta 54-letnia hospitalizowana na oddziale dermatologii z powodu obrączkowatych i nieregularnych zmian rumieniowo-zanikowych na kończynach górnych i dolnych. W obrębie ognisk na kończynach dolnych występowały owrzodzenia. Wyniki

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Antimalarial therapy for granuloma annulare: Results of a retrospective analysis

Cited by 25 publications

References 6 publications

Hydroxychloroquine in dermatology: New perspectives on an old drug

Hydroxychloroquine in dermatology: New perspectives on an old drug

Disseminated granuloma annulare in one case

Generalized granuloma annulare

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