Antimalarial polyoxygenated and prenylated xanthones from the leaves and branches of Garcinia mckeaniana

Auranwiwat, Chiramet; Laphookhieo, Surat; Rattanajak, Roonglawan; Kamchonwongpaisan, Sumalee; Pyne, Stephen G.; Ritthiwigrom, Thunwadee

doi:10.1016/j.tet.2016.09.018

Cited by 17 publications

(17 citation statements)

References 33 publications

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“…The determination of the chemical profiles of FEE (fruit ethanolic extract), EEFH (hexane fraction), EEFC (chloroform fraction), EEFA (ethyl acetate fraction), EEFW (hydromethanolic fraction), EEL (ethanol leaf extract), EELH (hexane fraction), EELC (chloroform fraction), EELA (ethyl acetate fraction), and EELW (hydromethanolic fraction) were performed based on UV, MS, and MS/MS data as compared with data described in the literature [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Twenty-six compounds were tentatively identified ( Table 1 and Table 2 , Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana

et al. 2020

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The aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of Garcinia gardneriana, a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, the following neoplastic cell lines were considered, along with an immortalized nontumor cell line. The antioxidant potential was determined, and the evaluation of antiradical air activity was performed. The levels of vitamin C and carotenoids were determined. The chemical profile was analyzed by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer using electrospray ionization interface. The chloroform fraction of the leaf showed antioxidant activity. The vitamin C content had lower values in fruits and higher in leaves. The content of carotenoids for fruits and leaves was expressive. The ethanolic extract and the hexane and chloroform fractions of fruits were active in all neoplastic lines tested. The leaves showed cytotoxic activity in the hexane fraction in the breast carcinoma line. The analysis of data obtained verified the presence of dimers, monomers, and tetramers of hexoses, polycarboxylic acids, xanthones, flavonoids, biflavonoids, and benzophenones.

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Section: Resultsmentioning

confidence: 99%

Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana

et al. 2020

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“…Oxygenated and prenylated xanthones have been investigated as new drugs due to their pharmacological properties [58], such as antimalarial [59] and antimicrobial activities [60], among others. Besides these xanthones, only a few structures are found in nature containing hydroxy group in the lateral chains, and some of them displayed interesting antimicrobial activities (Table 3).…”

Section: Natural Chiral Derivatives Of Xanthonesmentioning

confidence: 99%

Chiral Derivatives of Xanthones with Antimicrobial Activity

et al. 2019

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According to the World Health Organization, the exacerbated use of antibiotics worldwide is increasing multi-resistant infections, especially in the last decade. Xanthones are a class of compounds receiving great interest in drug discovery and development that can be found as natural products or obtained by synthesis. Many derivatives of xanthones are chiral and associated with relevant biological activities, including antimicrobial. The aim of this review is to compile information about chiral derivatives of xanthones from natural sources and their synthesized examples with antimicrobial activity.

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“…These compounds all contain two isoprene units. They were evaluated for their activity against the TM4 and K1 strains of P. falciparum with IC 50 values in the range of of 6.0–8.5 and 3.6–7.3 µM, respectively, and compounds 70 , 71 and 73 showed cytotoxicity against Vero cells with the IC 50 values in the range of 12.6–29.5 µM [ 42 ].…”

Section: Plant-derived Antimalarial Compoundsmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan

Shi

et al. 2018

IJMS

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled “Antimalarial activity of plant metabolites” by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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Antimalarial polyoxygenated and prenylated xanthones from the leaves and branches of Garcinia mckeaniana

Cited by 17 publications

References 33 publications

Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana

Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana

Chiral Derivatives of Xanthones with Antimicrobial Activity

Antimalarial Activity of Plant Metabolites

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