Antimalarial Natural Products

Kingston, David G. I.; Cassera, María B.

doi:10.1007/978-3-030-89873-1_1

Cited by 15 publications

(17 citation statements)

References 420 publications

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“…Quinine has long been the standard treatment for malaria. Spanish colonists in Peru during the 1500s found that drinking extracts from Cinchona bark cured their malarial symptoms [ 130 ]. Quinine is still an important treatment for malaria; however, resistance has slowly developed and quinine itself has a low therapeutic index due to significant side effects [ 130 ].…”

Section: Selected Bioactive Natural Products and Analogsmentioning

confidence: 99%

Lead/Drug Discovery from Natural Resources

Eichler

Klausner

et al. 2022

Molecules

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Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products are also included. Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.

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Section: Selected Bioactive Natural Products and Analogsmentioning

confidence: 99%

Lead/Drug Discovery from Natural Resources

Eichler

Klausner

et al. 2022

Molecules

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“…Keasling and Sanofi to produce 50 to 60 tons per year [ 40 , 41 ]. This corresponds to a third of the global annual need of the drug [ 40 , 41 , 42 ] and production costs are about 400 USD kg −1 [ 43 ]. However, the semisynthetic artemisinin was still more expensive than agricultural artemisinin leading to the sale of the production plant to Huvepharma [ 42 , 43 ].…”

Section: Industrially Relevant Enzyme Cascades For Api Synthesismentioning

confidence: 99%

“…This corresponds to a third of the global annual need of the drug [ 40 , 41 , 42 ] and production costs are about 400 USD kg −1 [ 43 ]. However, the semisynthetic artemisinin was still more expensive than agricultural artemisinin leading to the sale of the production plant to Huvepharma [ 42 , 43 ]. Artemisinin production in other plants such as Nicotiana benthamiana and Physcomitrella patens has also been successful [ 44 ].…”

Section: Industrially Relevant Enzyme Cascades For Api Synthesismentioning

confidence: 99%

Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment

Siedentop

Rosenthal

2022

IJMS

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Environmentally friendly and sustainable processes for the production of active pharmaceutical ingredients (APIs) gain increasing attention. Biocatalytic synthesis routes with enzyme cascades support many stated green production principles, for example, the reduced need for solvents or the biodegradability of enzymes. Multi-enzyme reactions have even more advantages such as the shift of the equilibrium towards the product side, no intermediate isolation, and the synthesis of complex molecules in one reaction pot. Despite the intriguing benefits, only a few enzyme cascades have been applied in the pharmaceutical industry so far. However, several new enzyme cascades are currently being developed in research that could be of great importance to the pharmaceutical industry. Here, we present multi-enzymatic reactions for API synthesis that are close to an industrial application. Their performances are comparable or exceed their chemical counterparts. A few enzyme cascades that are still in development are also introduced in this review. Economic and ecological considerations are made for some example cascades to assess their environmental friendliness and applicability.

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“…Extensive experience and clinical application of many natural products have been accumulated and combined with continuous improvements in chemical technologies and biological methods to treat diseases with little or no side effects. For instance, the antimalarial drugs artemisinin and quinine are extracted from Artemisia annua and Cinchona bark [ 1 , 2 ]. Antimicrobial drugs such as berberine, a natural pentacyclic isoquinoline alkaloid, are derived from the stems and roots of Berberis species [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids in Treatment of Chronic Kidney Disease

et al. 2022

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Chronic kidney disease (CKD) is a progressive systemic disease, which changes the function and structure of the kidneys irreversibly over months or years. The final common pathological manifestation of chronic kidney disease is renal fibrosis and is characterized by glomerulosclerosis, tubular atrophy, and interstitial fibrosis. In recent years, numerous studies have reported the therapeutic benefits of natural products against modern diseases. Substantial attention has been focused on the biological role of polyphenols, in particular flavonoids, presenting broadly in plants and diets, referring to thousands of plant compounds with a common basic structure. Evidence-based pharmacological data have shown that flavonoids play an important role in preventing and managing CKD and renal fibrosis. These compounds can prevent renal dysfunction and improve renal function by blocking or suppressing deleterious pathways such as oxidative stress and inflammation. In this review, we summarize the function and beneficial properties of common flavonoids for the treatment of CKD and the relative risk factors of CKD.

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Antimalarial Natural Products

Cited by 15 publications

References 420 publications

Lead/Drug Discovery from Natural Resources

Lead/Drug Discovery from Natural Resources

Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment

Flavonoids in Treatment of Chronic Kidney Disease

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