Antimalarial and β-hematin formation inhibitory activities of chromone derivatives

Maicheen, Chirattikan; Ungwitayatorn, Jiraporn

doi:10.2306/scienceasia1513-1874.2019.45.221

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Chromone containing natural and synthetic molecules exhibited important biological activities [1] . A wide range of medicinally significant properties displayed by chromone scaffolds are neuroprotective, [2] anti‐malarial, [3] anti‐fungal, [4] anti‐bacterial, [5] and anit‐HIV [6] . Chromone derivatives have also shown anticancer and antiviral potential [7–11] .…”

Section: Introductionmentioning

confidence: 99%

Chromone Scaffolds in the Treatment of Alzheimer's and Parkinson's Disease: An Overview

Sharma

2022

ChemistrySelect

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Neurodegenerative disorders such as Alzheimer's (AD) and Parkinson's disease (PD) usually starts gradually and progressively worsens, and are recognized as one of the leading causes of mortality and disability worldwide. Presently, all the available drugs for AD and PD are only for symptomatic relief, and are not capable of preventing and curing the disease. Chromone is a privileged structure for designing of novel drug agents with pharmacological potential, specifically in the field of AD and PD. The present review is focused on the significance of chromones as novel drug agents for the treatment of AD and PD. Chromone based acetylcholinesterase, butyrylcholinesterase, monoamine oxidase B, β-Secretase-1, inhibitors are discussed. As AD belongs to one of the most complex and multifactorial disorders, therefore, the multi-target drugs are urgently required. However, there has been a substantial research effort in designing multi-target drug agents. Therefore, in this review, chromone based multi-target inhibitors are also discussed. Furthermore, future directions for designing and developing potent chromone based drugs are reported.

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Section: Introductionmentioning

confidence: 99%

Chromone Scaffolds in the Treatment of Alzheimer's and Parkinson's Disease: An Overview

Sharma

2022

ChemistrySelect

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“…Chemically, chromone is 4Hchromen-4-one, also known as 4H-1-benzopyran-4-one which is a isomer of coumarin and a core part of various flavonoids. [131][132][133] Chromones exhibit wide range of biological applications like anti cancer, [134] anti bacterial, [135] anti fungal, [136] anti oxidant, [137] anti inflammatory, [138] anti-HIV, [139] anti malarial, [140] neuroprotective effects. [141] Chromones are structurally similar to chalcones and coumarins and having selective inhibition towards MAOÀ B.…”

Section: Study Of Chromonesmentioning

confidence: 99%

A Comprehensive Review of The Molecular Dynamic Study Of Chalcones, Coumarins and Chromones as Selective MAO‐B Inhibitors [2015‐Till Date]

Rachel Thomas,

Chandran,

Thomas Parambi

et al. 2024

ChemistrySelect

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Molecular dynamics (MD) simulation is an in silico method used in the biomolecular level of research to study how the protein interacts with the target with time. It provides a detailed information of the protein dynamics and ligand structure with the crucial amino acid interactions. Monoamine oxidase B (MAO−B) is a crucial isoenzyme responsible for the catalyses of oxidative deamination of various biogenic amines in the brain and peripheral tissues. The selective inhibitors of MAO−B are considered as the management of symptoms of neurodegenerative disorders like Alzheimer's disease(AD) and Parkinson disease(PD). Recently the structural scaffolds containing chalcones, coumarins and chromones derived candidates shown potent, selective, competitive and reversible type of MAO−B inhibitors. The structural similarities between the above scaffolds can produce almost similar type of interactions in the inhibitor binding cavity of MAO−B. Numerous molecular simulation reports were supported by the above mentioned fact. The current review focus on the last ten year molecular dynamics report of chalcones, coumarins and chromones towards MAO−B inhibition. The review also focuses on the software details used in the MD dynamics simulation and the structural requirement from each class of compound for the recognition of MAO−B inhibitory activity.

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Nucleophilic transformation of 3-substituted-6,8-dimethylchromones with phenylhydrazine under various reaction conditions: Theoretical, spectroscopic characterization and in silico ADME studies

Alshaye,

Ibrahim,

Badran

2024

Journal of Molecular Structure

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Antimalarial and β-hematin formation inhibitory activities of chromone derivatives

Cited by 5 publications

References 24 publications

Chromone Scaffolds in the Treatment of Alzheimer's and Parkinson's Disease: An Overview

Chromone Scaffolds in the Treatment of Alzheimer's and Parkinson's Disease: An Overview

A Comprehensive Review of The Molecular Dynamic Study Of Chalcones, Coumarins and Chromones as Selective MAO‐B Inhibitors [2015‐Till Date]

Nucleophilic transformation of 3-substituted-6,8-dimethylchromones with phenylhydrazine under various reaction conditions: Theoretical, spectroscopic characterization and in silico ADME studies

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