Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae

Şener, Bilge; Orhan, Ilkay Erdogan; Satayavivad, Jutamad

doi:10.1002/ptr.1346

Cited by 124 publications

(96 citation statements)

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“…Alkaloids are the main active constituents in this plant (Berkov et al 2004) which exhibited anti-fungal, anti-malarial, and cytotoxic activities (Sür-Altiner et al 1999;Sener et al 2003;Kaya et al 2010). Pancratistatin, which is the most important metabolite responsible for the therapeutic benefits of this plant, has been shown to have anti-viral, anti-neoplastic (Pandey et al 2005), and antiparasitic effect against Encephalitozoon intestinalis, a microsporidium causing intestinal and systemic infection in immunocompromised patients (Ouarzane-Amara et al 2001).…”

Section: Introductionmentioning

confidence: 96%

In vitro amoebicidal activity of ethanol extracts of Arachis hypogaea L., Curcuma longa L. and Pancratium maritimum L. on Acanthamoeba castellanii cysts

et al. 2011

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Acanthamoeba castellanii causes amoebic keratitis which is a painful sight-threatening disease of the eyes. Its eradication is difficult because the amoebas encyst making it highly resistant to anti-amoebic drugs, but several medicinal plants have proven to be more effective than the usual therapy. This study aimed to evaluate the in vitro amoebicidal activity of ethanol extracts of Arachis hypogaea L. (peanut), Curcuma longa L. (turmeric), and Pancratium maritimum L. (sea daffodil) on A. castellanii cysts. Acanthamoeba were isolated from keratitic patients, cultivated on 1.5% non-nutrient agar, and then incubated with different concentrations of plant extracts which were further evaluated for their cysticidal activity. The results showed that all extracts had significant inhibitory effect on the multiplication of Acanthamoeba cysts as compared to the drug control (chlorhexidine) and non-treated control, and the inhibition was time and dose dependent. The ethanol extract of A. hypogaea had a remarkable cysticidal effect with minimal inhibitory concentration (MIC) of 100 mg/ml in all incubation periods, while the concentrations of 10 and 1 mg/ml were able to completely inhibit growth after 48 and 72 h, respectively. The concentrations 0.1 and 0.01 mg/ml failed to completely inhibit the cyst growth, but showed growth reduction by 64.4-82.6% in all incubation periods. C. longa had a MIC of 1 g and 100 mg/ml after 48 and 72 h, respectively, while the concentrations 10, 1, and 0.1 mg/ml caused growth reduction by 60-90.3% in all incubation periods. P. maritimum had a MIC of 200 mg/ml after 72 h, while the 20-, 2-, 0.2-, and 0.02-mg/ml concentrations showed growth reduction by 34-94.3% in all incubation periods. All extracts seemed to be more effective than chlorhexidine which caused only growth reduction by 55.3-80.2% in all incubation periods and failed to completely inhibit the cyst growth. In conclusion, ethanol extracts of A. hypogaea, C. longa, and P. maritimum could be considered a new natural agent against the Acanthamoeba cyst.

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Section: Introductionmentioning

confidence: 96%

In vitro amoebicidal activity of ethanol extracts of Arachis hypogaea L., Curcuma longa L. and Pancratium maritimum L. on Acanthamoeba castellanii cysts

et al. 2011

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“…Atividades biológicas e farmacológicas marcantes têm sido atribuídas aos alcalóides de Amarilidáceas, tais como atividade anticolinesterásica da galantamina, citotoxicidade e ação antitumoral da licorina, além de atividades antiinfl amatória, antiviral e antimalárica relatadas de muitos núcleos desses alcalóides. (Harvey, 1995;Weniger et al, 1995;Rhee et al, 2001;Sener et al, 2003;BarbosaFilho et al, 2006a,b).…”

Section: Introductionunclassified

Avaliação in vitro das atividades antiinflamatória, antioxidante e antimicrobiana do alcalóide montanina

Castilhos¹,

Giordani²,

Henriques³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Diversas propriedades biológicas, dentre as quais atividade antiparasitária, antitumoral, antiviral e anticolinesterásica são associadas aos extratos e produtos isolados, incluindo alcalóides de espécies de Amarilidáceas. Neste trabalho verifi cou-se para o alcalóide montanina, isolado dos bulbos de Rhodophiala bifi da (Herb.) Traub (Amaryllidaceae), atividade antioxidante e ação inibitória sobre o crescimento de culturas de Saccharomyces cerevisae (ATCC 2601), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 6538), Staphylococcus epidermides (ATCC 12228) e Escherichia coli (ATCC 25922). A atividade antiinfl amatória avaliada através da determinação da capacidade antiquimiotáxica da amostra apresentou resultados não signifi cativos na dose empregada.Unitermos: Amaryllidaceae, Rhodophiala bifi da, montanina, alcalóides.ABSTRACT: "In vitro evaluation of the antioxidant, anti-infl ammatory and antimicrobial activities of the montanine alkaloid". Several biological properties, such as antiparasite, antitumor, antiviral and anticholinesterasic activities, are associated with extracts and isolated products, including alkaloids from Amaryllidaceae species. In this study, the antioxidant activity and inhibitory action on the growth of cell cultures of Saccharomyces cerevisae (ATCC 2601), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 6538), Staphylococcus epidermides (ATCC 12228) and Escherichia coli (ATCC 25922) were observed to the montanine alkaloid, isolated from the bulbs of Rhodophiala bifi da (Herb.) Traub (Amaryllidaceae). The antiinfl ammatory activity, which was evaluated through the sample antichemotaxis ability determination, was not signifi cant in the used dose.

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“…4 The main source of galanthamine is still its isolation from certain Amaryllidaceae plants. Only seven genera including 48 species are native in Europe.…”

mentioning

confidence: 99%

Accurate product ion mass spectra of galanthamine derivatives

Jegorov¹,

Buchta²,

Sedmera

et al. 2006

J. Mass Spectrom.

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Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae

Cited by 124 publications

References 10 publications

In vitro amoebicidal activity of ethanol extracts of Arachis hypogaea L., Curcuma longa L. and Pancratium maritimum L. on Acanthamoeba castellanii cysts

In vitro amoebicidal activity of ethanol extracts of Arachis hypogaea L., Curcuma longa L. and Pancratium maritimum L. on Acanthamoeba castellanii cysts

Avaliação in vitro das atividades antiinflamatória, antioxidante e antimicrobiana do alcalóide montanina

Accurate product ion mass spectra of galanthamine derivatives

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