Antimalarial activity of Lactucin and Lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.

Bischoff, Theodore A.; Kelley, Charles J.; Karchesy, Yvette M.; Laurantos, Maria; Nguyen-Dinh, Phuc; Arefi, Abdul Ghafoor

doi:10.1016/j.jep.2004.06.031

Cited by 160 publications

(95 citation statements)

References 9 publications

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“…Lactucopicrin, 8-desoxylactucin, and three sesquiterpene lactone glycosides: crepidiaside B, sonchuside A, and ixerisoside D [72]. Lactucin and lactucopicrin: sesquiterpene lactones [73]. Quercetin, kaempferol, luteolin, apigenin, crysoeriol and caffeoyl derivatives, polyphenols [74].…”

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confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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“…Some other studies reported that inulin (chicory fiber) could increase the rate of apoptosis and thereby helps preventing cancer and inhibiting the colonic preneoplastic lesions [29] . In addition, cichoriin and lactucin, extracted from the chicory flowers and roots respectively, have been reported to be sensitive to light [2,1,10] . Therefore, cichoriin and Lactucin could be the main photosensitizers that confer chicory's phototoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple uses of different plant parts have been reported. Roasted roots that are rich in inulin have been used as a coffee substitute for centuries, root extracts have also been used as a remedy for malaria [1] , antibacterial activity [2] , and cancer of the breast and face [3,4] , and against Ehrlich ascites carcinoma [5] . Leaves are very common in salad as they promote appetite, digestion [6] , and possess strong antioxidant properties [2] .…”

Section: Introductionmentioning

confidence: 99%

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Sensitization of Photohemolysis by a New Extraction from Flowers and Aerial Parts of Cichorium Pumilum Jacq: Effects of Inulin and Hydrogen Peroxide

Al-Akhras¹,

Amin²,

Mohammad³

et al. 2007

American J. of Pharmacology and Toxicology

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Addition of inulin and hydrogen peroxide to new photosensitizers extracted from the flowers and aerial parts of the chicory (Cichorium Pumilum Jacq) have been investigated. Some of the isolated photosensitizers remain unidentified compounds. Chicory extracts are found to be dependent on light and temperature. Higher photohemolysis rate was noticed under the influence of light as compared to temperature. The effect of H 2 O 2 on phototoxicity reported in this study showed a rapid reduction in the fractional hemolysis percentage at higher temperature. Compared to erythrocytes with higher concentrations and under the influence of solar irradiance 505.29±24.96w/m 2 , erythrocytes with lower concentrations of inulin and H 2 O 2 were ruptured faster. Samples with 0.95mg/ml of herb extract and different concentrations of inulin (1mg/ml -2mg/ml) shows no temperature effects at 40 C in the absent of sunlight.

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“…Finally, Lactucin and Lactucopicrin, responsible of the characteristic bitter taste, largely present in Lactuca and Cichorium species, are endowed with antimalarial, anti-inflammatory and sedative properties (Bischoff et al 2004,Wesolowska et al 2006.…”

Section: Introductionmentioning

confidence: 99%

Extraction and Evaluation of Nutraceutical Molecules in Wastes of Fruit and Vegetables

Doria¹,

Internationals²

2017

IJFNS

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Fruit and vegetables wastes not only have no commercial value, but also require expensive operations of removal and disposal, representing a significant cost for the manufacturers of plant products. However, this material may represent an important resource of commercially worth phyto-molecules endowed with various nutraceutical properties. In the present work, we have verified the possibility of using fruit and vegetable waste materials as a source of bioactive compounds. Several nutraceutical compounds of high economic interest were extracted and quantified from various waste plant materials deriving from the production phase ("first-gamma products") or discarded during the preparation of fresh ready-to-cook or ready-to-eat packaged products ("fourth-gamma products"). Obtained results showed that, despite the precarious and uncontrolled conditions which plant wastes products are subjected, the levels of the examined bioactive compounds are present in relevant amount, also in the parts of the plant that are discarded during the preparation of the ready-to-eat/cook products.

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Antimalarial activity of Lactucin and Lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.

Cited by 160 publications

References 9 publications

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Sensitization of Photohemolysis by a New Extraction from Flowers and Aerial Parts of Cichorium Pumilum Jacq: Effects of Inulin and Hydrogen Peroxide

Extraction and Evaluation of Nutraceutical Molecules in Wastes of Fruit and Vegetables

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