Antimalarial Active Principles ofSpathodea campanulata Stem Bark

Amusan, Oluwole O. G.; Adesogan, E. K.; Makinde, J. M.

doi:10.1002/(sici)1099-1573(199612)10:8<692::aid-ptr928>3.0.co;2-o

Cited by 38 publications

(9 citation statements)

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“…[205][206][207] Compound 117 has been previously reported to possess anti-plasmodial activity. 208 and in this study the compound showed an appreciable anti-plasmodial activity with an IC 50 value of 6.8 mg mL À1 at the tested concentration using CQS of P. falciparum. The lower activity of the compound as compared to the crude extract could be due to synergistic effect with other compounds, decomposition during fractionation.…”

Section: Pentacyclic Triterpenoidssupporting

confidence: 60%

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

et al. 2015

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As a whole, the African continent is highly endowed with a huge floral biodiversity. Natural products which have been isolated from plants growing in this region have shown interesting chemical structures with diverse biological activities, which could serve as a starting point for drug discovery. In this study, a literature survey led to the collection of 864 secondary metabolites from 101 plant species from 57 plant families. A correlation between the known biological activities of isolated compounds and the ethnobotanical uses of the plants has been attempted. This review is a survey of the bioactivities of alkaloids and terpenoids which have been isolated from Southern African flora versus the ethnobotanical uses of the plants used in Southern African traditional medicine.

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Section: Pentacyclic Triterpenoidssupporting

confidence: 60%

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

et al. 2015

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“…MS and MS/MS data of all the identified compounds are shown in Table S1. The chemical structure of the 11 characterized compounds, which was confirmed by comparison with existing structures [22][23][24][25][26][27]30], is shown in Table 2. Compound 5,7-dihydroxy-4-metilcoumarin was detected in this plant for the first time, through the mass spectral database mzCloud.…”

Section: Chemical Composition Of S Campanulata Fractions and Sub-fractionsmentioning

confidence: 67%

“…Data about the chemical characterization of S. campanulata are limited. Nevertheless, previous studies undertaken on the stem bark and leaves have shown the presence of phenolic acids, flavonoids, triterpenoids, iridoids, and sterols [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

New Insights into Bioactive Compounds from the Medicinal Plant Spathodea campanulata P. Beauv. and Their Activity against Helicobacter pylori

et al. 2020

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The medicinal plant Spathodea campanulata P. Beauv. (Bignoniaceae) has been traditionally applied for the prevention and treatment of diseases of the kidney and urinary system, the skin, the gastrointestinal tract, and inflammation in general. The present work shows for the first time how chemical components from this plant inhibit Helicobacter pylori growth by urease inhibition and modulation of virulence factors. The crude extract and the main fractions of S. campanulata bark were tested on H. pylori isolated strains and the active ones were further fractionated. Fractions and sub-fractions of the plant crude extract were characterized by ultra-high-performance liquid chromatographic tandem high resolution-mass spectrometry detection (UHPLC-HRMS). Several phenolics and triterpenoids were identified. Among the sub-fractions obtained, SB2 showed the capacity to inhibit H. pylori urease in a heterologous bacterial model. One additional sub-fraction (SE3) was able to simultaneously modulate the expression of two adhesins (HopZ and BabA) and one cytotoxin (CagA). The flavonol kaempferol was identified as the most interesting compound that deserves further investigation as a new hit for its capacity to modulate H. pylori virulence factors.

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“…Of the three triterpenes that were isolated from M. caffra and M. obtusifolia (ursolic acid, taraxerol and sawamilletin), only ursolic acid showed any appreciable anti-plasmodial activity (IC 50 6.8 μg/mL) at the concentration tested. Ursolic acid has been previously reported to possess anti-plasmodial activity [21], and its presence in M. caffra could have contributed to the observed bioactivity of the plant. The lower activity of the extracted ursolic acid (compared to the crude M. caffra extract) could indicate a synergistic effect with other compounds, decomposition during fractionation, or removal of a protective matrix.…”

Section: Resultsmentioning

confidence: 99%

Anti-Plasmodial Activity of Some Zulu Medicinal Plants and of Some Triterpenes Isolated from Them

et al. 2013

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Abstract:Mimusops caffra E. Mey. ex A.DC and Mimusops obtusifolia Lam (both members of the Sapotaceae family), and Hypoxis colchicifolia Bak (family Hypoxidaceae) are used by traditional healers in Zululand to manage malaria. Anti-plasmodial investigation of the crude extracts and some triterpenes isolated from the plants showed activity against a chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10). Among the crude extracts the leaves of M. caffra exhibited the highest activity, with an IC 50 of 2.14 μg/mL. The pentacyclic tritepenoid ursolic acid (1), isolated from the leaves of M. caffra was the most active compound (IC 50 6.8 μg/mL) as compared to taraxerol (2) and sawamilletin (3) isolated from the stem bark of M. obtusifolia (IC 50 > 100). Chemical modification of the ursolic acid (1) to 3β-acetylursolic acid (4) greatly enhanced its anti-plasmodial activity. Compound 4 reduced parasitaemia against Plasmodium berghei by 94.01% in in vivo studies in mice. The cytotoxicity of 3β-acetylursolic acid (IC 50 ) to two human cell lines (HEK293 and HepG2) was 366.00 μg/mL and 566.09 μg/mL, respectively. The results validate the use of these plants in folk medicine.

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Antimalarial Active Principles ofSpathodea campanulata Stem Bark

Cited by 38 publications

References 0 publications

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

New Insights into Bioactive Compounds from the Medicinal Plant Spathodea campanulata P. Beauv. and Their Activity against Helicobacter pylori

Anti-Plasmodial Activity of Some Zulu Medicinal Plants and of Some Triterpenes Isolated from Them

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