Antimalarial Active Principles of Spathodea campanulata Stem Bark

Amusan, Oluwole O. G.; Adesogan, E. K.; Makinde, J. M.

doi:10.1002/(sici)1099-1573(199612)10:8<692::aid-ptr928>3.3.co;2-f

Cited by 21 publications

(23 citation statements)

References 6 publications

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“…Local healers in the study area used S. campanulata to treat typhoid, malaria, and wounds. Ursolic acid and its derivatives have been isolated from the bark of S. campanulata as anti-malarial compounds [126]. Other active compounds such as iridoid ajugol, p-hydroxy-benzoic acid and methyl p-hydroxybenzoate have also been isolated from this medicinal plant [127].…”

Section: Potential Allelopathic Activity By Leachates Of Medicinal Plantmentioning

confidence: 99%

“…In this study, the leachates of Carica papaya, Momordica charantia, Azadirachta indica, Alstonia boonei, Spathodea campanulata, Ficus exasperata, Phyllanthus urinaria, Eclipta alba, Cleistopholis patens, and Kalanchoe integra showed inhibitory effects on lettuce radicle (67-86%). These medicinal species were also of high importance based on their reported ethnobotanical indices reported in this study area and also in other studies [69,75,76,99,102,108,119,126]. It can be inferred from these highly significant positive correlations that the bioactive substances associated with curative effects of the understudied medicinal plants may play a role in the allelopathy of such species.…”

Section: Correlation Between Ethnobotanical Indices and Allelopathic mentioning

confidence: 99%

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Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

et al. 2017

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This paper presents the first application of ethnobotanical studies to screen for allelopathic species among medicinal plants for sustainable weed management. This study assesses the possible relationship between ethnobotanical indices and allelopathy of medicinal plants. Ethnobotanical data were collected in 2016 by using semi-structured interviews with 140 informants in the Ejisu-Juaben Municipality, Ghana. Data were analysed using statistical tool and ethnobotanical indices including use value (UV), Fidelity Level (FL), Relative Frequency of Citation (RFC). The Sandwich and Dish pack methods were respectively used to evaluate allelopathy through leachates and volatiles of collected samples. Ninety-five species belonging to 43 families are reported in this study, with leaves (52%) cited the most utilised plant part. Cleistopholis patens (UV = 0.54; FL = 90.7%; RFC = 0.37) and Ocimum gratissimum (UV = 0.37; FL = 38.4%; RFC = 0.35) were among the most cited species. Thirty-two species showed inhibition (≥49.3%) by leachates, while twenty-four species were found with potential volatile inhibitory compounds against lettuce radicle growth. There was a significant positive correlation (Pearson) between the UV and RFC of medicinal plants and allelopathy by leaf leachates (r = 0.639 **; p = 0.01 and r = 0.653 **; p = 0.01 respectively). This systematic documentation of medicinal plants in Ejisu-Juaben Municipality shows medicinal plants with ethnomedicinal values and potential allelopathy that can be utilised in sustainable weed control.

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Section: Potential Allelopathic Activity By Leachates Of Medicinal Plantmentioning

confidence: 99%

Section: Correlation Between Ethnobotanical Indices and Allelopathic mentioning

confidence: 99%

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

et al. 2017

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“…Other folklore uses of the plant in Ghana include the treatment of dyspepsia and peptic ulcer (stem bark and leaf); arthritis and fracture (leaf, root bark and fruit); toothache and stomach ache (stem bark); and stomach ulcer (root bark and seed) (Agbovie et al, 2002). The stem bark preparations of the plant are reported to have wound healing (Houghton et (Makinde et al, 1988;Amusan et al, 1996), molluscicidal (Mendes et al, 1986;Amusan et al, 1995), and hypoglycemic, anticomplement and anti-HIV activities (Niyonzima et al, 1993(Niyonzima et al, , 1999. The stem bark contains several chemical substances such as 3β-acetoxyoleanolic acid, siaresinolic acid, 3β-acetoxy-12-hydroxyoleanan-28, 13-olide and oleanolic acid (Ngouela et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of extracts and topical products of the stem bark of <i>Spathodea campanulata</i> for wound healing

Ofori-Kwakye

Kwapong²,

Adu³

2010

Afr. J. Trad. Compl. Alt. Med.

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The antibacterial activity of the aqueous, ethanol, methanol and petroleum ether Soxhlet extracts of sundried stem bark of Spathodea campanulata P. Beauv. (Bignoniaceae) was investigated by testing the extracts against B. subtilis, E. coli, P. aeruginosa and S. aureus. The minimum inhibitory concentration (MIC) of the methanol extract was determined against the four bacteria strains and C. albicans using the broth dilution method. Four topical products were prepared by incorporating the methanol extract of S. campanulata (20 % w/w) into aqueous cream, soft paraffin, emulsifying ointment and simple ointment bases and evaluated for their in vitro antimicrobial efficacy. The effect of storage time on the activity of the methanol extract of S. campanulata and S. campanulata extract incorporated in aqueous cream base was also investigated. The methanol and ethanol extracts showed good activity while the aqueous and petroleum ether extracts exhibited little activity. The methanol extract showed the best antibacterial activity. The MIC of the methanol extract of S. campanulata was: C. albicans (45 -50 mg/ml), B. subtilis and E. coli (50 -55 mg/ml), P. aeruginosa (60 -65 mg/ml), S. aureus (145 -150 mg/ml). Antimicrobial activity of S. campanulata in the topical bases was in the order: aqueous cream > emulsifying ointment > simple ointment > white soft paraffin. Antimicrobial activity of S. campanulata in aqueous cream decreased (p < 0.05) upon storage at room temperature for 6-months. The antifungal activity of the methanol extract of S. campanulata was reduced (p < 0.05) upon storage while antibacterial activity was largely unaffected.

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“…Spathodic acid, steroids, saponins, ursolic acid, tomentosolic acid and pectic substances have ever been isolated from the stem bark (NIYONZIMA et al, 1999;NGOUELA et al, 1990;SONDENGAM, 1988;MSONTHI;MAKHUBU, 1995;MAKINDE, 1996). The leaves have furnished spathodol, caffeic acid, other phenolic acids and flavonoids (NGOUELA et al, 1991;SUBRAMANIAN;SULOCHANA;NAGARAJAN, 1973;EL-HELA, 2001a;EL-HELA, 2001b), while the fruits contain poliphenols, tanins, saponins and glucosides (AMUSAN; MSONTHI; MAKHUBU, 1995).…”

Section: Introductionmentioning

confidence: 99%

Iridóide glicosilado e derivados fenólicos antifúngicos isolados das raízes de Spathodea campanulata

et al. 2007

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The chemical study of Spathodea campanulata (Bignoniaceae) roots peels afforded an iridoid glucoside (ajugol) and two phenolic derivatives (p-hydroxy-benzoic acid and methyl p-hydroxy-benzoate). The compounds were characterized upon spectral data interpretation. Bioactivities of the constituents were evaluated against fungus Cladosporium herbarum. Key words: Spathodea campanulata, ajugol, phenolic compounds, Cladosporium herbarum ResumoO estudo químico das cascas das raízes de Spathodea campanulata (Bignoniaceae) conduziu ao isolamento de um irióide glicosilado (ajugol) e dois derivados fenólicos (ácido p-hidroxi-benzóico e p-hidroxi-benzoato de metila). Os compostos foram identificados com base na interpretação dos seus dados espectrais. A atividade biológica destes constituintes foi avaliada contra o fungo Cladosporium herbarum.

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Antimalarial Active Principles of Spathodea campanulata Stem Bark

Cited by 21 publications

References 6 publications

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

Antimicrobial activity of extracts and topical products of the stem bark of <i>Spathodea campanulata</i> for wound healing

Iridóide glicosilado e derivados fenólicos antifúngicos isolados das raízes de Spathodea campanulata

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