Antilithiatic effect of Peucedanum grande C. B. Clarke in chemically induced urolithiasis in rats

Kumar, B.N.; Wadud, Abdul; Jahan, Nasreen; Sofi, Ghulamuddin; Bano, Humaira; Makbul, Shaikh Ajij Ahmed; Husain, Sadique

doi:10.1016/j.jep.2016.10.081

Cited by 23 publications

(17 citation statements)

References 13 publications

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“…Cystone was used as a standard control in the present study considering it is a polyherbal formulation which is extensively used for the treatment of urolithiasis in clinical practice [37] . Its antiurolithiatic efficacy is produced by multiple mechanisms that include its crystal disintegrating ability, diuretic and urinary smooth muscle relaxing activity [28] . Therefore, it provides numerous ways for comparing the efficacy and inferring the mechanism of action of the test drug.…”

Section: Discussionmentioning

confidence: 99%

“…Volume and pH of urine samples was determined followed by dipstick urine analysis prior to centrifugation at 2500 rpm for 5 min. Urine samples were then subjected to microscopic evaluation of crystalluria and quantitative estimation of calcium, phosphorus, uric acid, protein and magnesium on a Carelab 200 autoanalyzer using respective diagnostic kits [28] . Oxalate and citrate content in urine was determined by the methods of Hodgkinson, 1970 [29] and Şeker et al., 2009 [30] , respectively.…”

Section: Methodsmentioning

confidence: 99%

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Anticalcifying effect of Daucus carota in experimental urolithiasis in Wistar rats

Bawari

Sah

Tewari

2020

Journal of Ayurveda and Integrative Medicine

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Background Urolithiasis is a burgeoning disease that results from pathological biomineralization. Daucus carota L. is a widely consumed food crop with reported nephroprotective and diuretic activity. Its potential for Ashmari bhedan (destruction of stone/calculi) or treatment of urinary calculi has been explored traditionally. However, no scientific evidence is available to prove its antiurolithiatic efficacy. Moreover, establishing the antiurolithiatic effects of D . carota , an extensively consumed commodity with numerous health benefits, would provide a beneficial dietary measure for the prevention and cure of urolithiasis. Objective The study aimed at investigating in vivo antiurolithiatic potential of hydroethanolic extract of D . carota roots against calcium oxalate urolithiasis. Materials and methods Ethylene glycol and ammonium chloride induced hyperoxaluria model of urolithiasis in male Wistar rats was used for the study. Urine and serum parameters and, kidney histopathology was used to determine the antilithic efficacy of D . carota root extract. Results D . carota extract significantly ameliorated abnormal urinary levels of calcium, oxalate, phosphate, magnesium, citrate, protein and uric acid in lithogenic rats. Serum BUN, creatinine and uric acid levels; and calcium, phosphate and oxalate deposition in kidney tissue were also rendered normal following D . carota treatment. D . carota extract also prevented oxidative stress mediated renal tissue degeneration both prophylactically and curatively. Conclusion This study suggests antiurolithiatic effect of D . carota roots, which can be attributed to its anticrystallization property, ability to ameliorate urine and serum biochemistry and renal cellularity.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Anticalcifying effect of Daucus carota in experimental urolithiasis in Wistar rats

Bawari

Sah

Tewari

2020

Journal of Ayurveda and Integrative Medicine

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“…Extract was filtered by filter paper (Whatman no. 40) and then evaporated on water bath at 60°C till it dried completely 6 , 7 , 19 . The yield of hydroalcoholic extract was found to be 10.05% w/w .…”

Section: Methodsmentioning

confidence: 99%

“…The study was carried out by the method of Ahmed et al (2013) 6 and Kumar et al (2016) 7 with some modification in the treatment schedule. All the animals were weighed and divided into six groups of six animals each.…”

Section: Methodsmentioning

confidence: 99%

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Effect of Piper cubeba L. fruit on ethylene glycol and ammonium chloride induced urolithiasis in male Sprague Dawley rats

Bano

Jahan

Makbul

et al. 2018

Integrative Medicine Research

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Antiurolithiatic effects of Cassia fistula Lin. fruit extracts on ethylene glycol‐induced nephrolithiasis in rats

Partovi,

Fatemi,

Ebadzadeh

2024

Microscopy Res & Technique

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Urinary stones are a growing disease that results from pathological biomineralization. Cassia fistula Lin. is traditionally used to treat urinary stones. However, no scientific evidence is available to prove its antilithiatic effect. This study evaluates the antilithiatic potential of aqueous and ethanolic extract of Cassia fistula Lin. fruit (Cff) against calcium oxalate kidney stones. Forty‐two male Wistar rats were divided into seven groups (n = 6/group): Group I (control), Group II (rats treated with ethylene glycol and ammonium chloride developed nephrolithiasis after 28 days), Group III (lithiatic rats receiving distilled water for 30 days), Group IV and V (lithiatic rats receiving aqueous extract of Cff at doses of 1 and 100 mg/kg body weight for 30 days, respectively) and Group VI and VII (lithiatic rats receiving ethanolic extract of Cff at doses of 1 and 100 mg/kg body weight for 30 days, respectively). Some parameters of urine and serum, and also renal oxidative stress and histopathology were used to determine the antilithiatic effect of aqueous and ethanolic extract of Cff. Therefore, the types of extracts of Cff improved abnormal levels of urine, serum, and renal oxidative stress and histopathology parameters. This antilithiatic effect of aqueous and ethanolic extracts of Cff, can be attributed to the anti‐crystallization and antioxidant properties of the extracts and the ability to improve urine and serum biochemistry.Research Highlights Ethylene glycol and ammonium chloride‐induced urolithiasis, aggregation of calcium oxalate deposits, increase of some urinary and serum parameters, relative kidney weight, kidney size and MDA activity, decrease of some urinary parameters, relative body weight and SOD activity. Aqueous and ethanolic extracts of Cassia fistula Lin. lead to the treatment of urolithic rats by decreasing levels of urinary oxalate, phosphate, urea, serum urea, uric acid, creatinine, calcium, phosphate, MDA, kidney weight and kidney size, increasing levels of urinary calcium, creatinine, magnesium, citrate, body weight and SOD activity in the kidney, eliminating CaOx deposition (esp. ethanolic extract).

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Antilithiatic effect of Peucedanum grande C. B. Clarke in chemically induced urolithiasis in rats

Cited by 23 publications

References 13 publications

Anticalcifying effect of Daucus carota in experimental urolithiasis in Wistar rats

Anticalcifying effect of Daucus carota in experimental urolithiasis in Wistar rats

Effect of Piper cubeba L. fruit on ethylene glycol and ammonium chloride induced urolithiasis in male Sprague Dawley rats

Antiurolithiatic effects of Cassia fistula Lin. fruit extracts on ethylene glycol‐induced nephrolithiasis in rats

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