Antilipogenic effect of green tea extract in C57BL/6J‐Lep^ob/ob mice

Abstract

The objective of this study was to determine the effects of green tea extract (GTE) on lipid metabolism in obese animal models. Male C57BL/6J-Lep ob/ob mice were divided into control and GTE (0.05 g/100 g diet) groups, which were fed a high-fat (20 g/100 g diet) diet for 12 weeks. Supplementation of GTE significantly reduced (p < 0.01) perirenal and total white adipose tissue weights compared with the control group. Also, the plasma HDL-cholesterol level was significantly higher in the GTE group than in the control group, therefore the GTE group showed a higher HDL-cholesterol/total-cholesterol ratio (HTR) and lower atherogenic index (AI) level than the control group. A reduction of hepatic triglyceride content and adipose tissue weight in the GTE group was related to the suppression of enzyme activities for fatty acid synthesis (glucose-6-phosphate dehydrogenase and malic enzyme) without affecting fatty acid oxidation enzyme (beta-oxidation and carnitine palmitoyl transferase) activities in hepatic and adipose tissue. The current results showed that supplementation of green tea extract is beneficial for antiobesity by the suppression of lipogenesis via regulation of related enzyme activities in hepatic and adipose tissue.

White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice

“…Studies with green tea are also controversial in this regard. Some authors found reduction of cholesterol in mice (KIM et al, 2009;RICHARD et al, 2009), while others did not find any difference (FARDET et al, 2008;ZHENG et al, 2004). The controversy also exists in clinical studies showing beneficial (HSU et al, 2008;NAGAO;HASE;TOKIMITSU, 2007) or no effect on blood cholesterol (MAKI et al, 2009) after green tea supplementation.…”

“…In the present study, no effect of white tea extract was observed on the parameters related to reduction of body weight or adiposity, such as weight gain and final weight, visceral adiposity, and adipocyte area. Green tea has been claimed useful for weight gain and adiposity reduction (BRUNO et al, 2008;KIM et al, 2009;MAKI et al, 2009). Nagao (NAGAO; HASE; TOKIMITSU, 2007) hypothesized that the mechanism by which catechins reduce body fat may be related to the increase of energy expenditure.…”

“…These authors also observed increased excretion of lipids after ingestion of a mixture of these teas. Although some studies have not shown the effect of catechins on the reduction of triacylglycerols (KIM et al, 2009;NAGAO;HASE;TOKIMITSU, 2007), the available literature on green tea and its catechins shows that it can improve the lipid profile by decreasing the luminal hydrolysis of lipids and thereby reduce its intestinal absorption (BABU; LIU, 2008;KOO;NOH, 2007). Furthermore, it has been reported that catechins regulate the expression of hepatic LDL receptors modulating the lipid synthesis, excretion, and intracellular processing (BABU; LIU, 2008;KOO;NOH, 2007).…”

Depression by a Green Tea Extract of Alcohol-Induced Oxidative Stress and Lipogenesis in Rat Liver

“…[24][25][26][27][28] Green tea inhibited lipid peroxidation by epicatechin-3-O-gallate, epigallocatechin-3-O-gallate and gallocatechin-3-O-gallate. [29][30][31][32] Supplementary catechins significantly protected against inflamed liver injury by depressing ROS-enhanced pro-inflammatory NF-B and activator protein-1 activity and apoptotic cell death. 26,29) Supplementation with a green tea extract has also been beneficial for anti-lipogenesis by inhibiting the activity of several lipogenic enzymes and their expression in hepatic and adipose tissue.…”

“…26,29) Supplementation with a green tea extract has also been beneficial for anti-lipogenesis by inhibiting the activity of several lipogenic enzymes and their expression in hepatic and adipose tissue. 30,31) The effect of traditional herbal formulae (Zhong Yao) against experimental hypercholesterolemia has also been discussed for a herbal formulation of green tea and five other kinds of herbs. 32) Caffeine, another important ingredient present in a tea extract, ameliorated alcohol-induced liver dysfunction, steatosis and inflammation.…”