Antileukotriene Drugs in the Management of Asthma

Long‐term asthma control with oral montelukast and inhaled beclomethasone for adults and children 6 years and older

“…The available data indicate that while the response distribution overlaps are generally similar, the mean effect of inhaled corticosteroids on FEV 1 in mild-to-moderate asthma is greater than that of anti-leukotriene agents such as montelukast. The present findings suggest, however, that the effect of inhaled corticosteroids may be offset over time by the better adherence with oral treatment, as some authors have proposed [13,29]. This hypothesis should be tested prospectively in studies designed to address this question since not all patients enrolled in the primary studies entered the extension periods, potentially introducing a selection bias; therefore, these data should be considered exploratory.…”

Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4+T Cells duringAspergillus fumigatusAntigen Exposure

“…The underlying mechanism of the inflammatory response observed in allergic asthma is attributable primarily to the activities of CD4 1 T cells (1,44,45). Although several therapies are available for the treatment of asthma, they all have side effects or are ineffective in particular patients (46,47). Moreover, many asthma medications have systemic immunosuppressive actions that can promote infection (48).…”

The role of phospholipase A2-derived mediators in obesity

“…Although there has been no clear evidence that leukotrienes are involved in the progression of obesity, the need of further examination is suggested. Leukotrienes have long been associated with inflammation that results in asthma and drugs that act to inhibit leukotrienes have proven to be an effective treatment of asthma (35). Although not strong, there is indirect evidence that the production of leukotrienes may be associated with obesity (12;34).…”