Antileukemic Potential of<i>Momordica charantia</i>Seed Extracts on Human Myeloid Leukemic HL60 Cells

Soundararajan, Ramani; Prabha, Punit; Rai, Umesh; Dixit, Aparna

doi:10.1155/2012/732404

Cited by 18 publications

(11 citation statements)

References 41 publications

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“…The findings of this study negate the report of Soundararajan et al (2012) which explained that M. charantia seed fractions did not exhibit any antiproliferative activity. However, Soundararajan et al (2012) reported that the differentiation-inducing fraction in M. charantia was non-proteinaceous in nature, showing that the differentiation-inducing factor of M. charantia is different from its antitumor factors.…”

Section: Discussioncontrasting

confidence: 93%

“…However, Soundararajan et al (2012) reported that the differentiation-inducing fraction in M. charantia was non-proteinaceous in nature, showing that the differentiation-inducing factor of M. charantia is different from its antitumor factors. Thus, the present study for the first time describes the differentiation inducing action of the methanol leaf extract of M. charantia which can be further studied as an inducer of differentiation and regeneration of normal cell, either alone or combined with the suboptimal concentrations of other known inducers of differentiation.…”

Section: Discussionmentioning

confidence: 99%

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Anti-proliferative and cytotoxic effects of methanol extract of the leaves of Momordica charantia L. (Cucurbitaceae) on vascular smooth muscle cells (VSMC) and HT-29 cell lines

Ofuegbe¹,

Oyagbemi²,

Omóbòwálé³

et al. 2017

J. Med. Plants Res.

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Momordica charantia has been used traditionally for the treatment of several ailments. Some natural plant products are known to exhibit cytotoxic or anti-proliferative effects on cancer cell lines, such plants offer a promising therapeutic approach as an anti-tumor agent. In this study, the anti-proliferative effects of graded concentrations of methanol leaf extract of M. charantia (MEMC) at different point time was examined on vascular smooth muscle cells (VSMC), and human colorectal adenocarcinoma cell lines (HT-29) were investigated using the MTT proliferation assay. The result showed that after 24 and 48 h, the effect of MEMC on the VSMC alone and in the presence of the mitogens was more of proliferation. In the case of HT 29 cytotoxic study, the extract at all doses used caused a cytotoxic effect. The effect of the extract of M. charantia was more pronounced and consistent at 72 h time point exhibiting cytotoxic actions against cancer cell lines, the extract showed no toxic action to normal cells. This suggests a possible use of the plant M. charantia to identify compounds of possible interest in the treatment of cancer. While the extract possesses proliferative effects on the VSMCs, the reverse is the case, where it exhibited cell inhibitory effects on HT 29 cell lines indicating that the plant exhibit cytotoxic effects and could then serve as lead agents in the search for anticancer drugs from natural products.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Anti-proliferative and cytotoxic effects of methanol extract of the leaves of Momordica charantia L. (Cucurbitaceae) on vascular smooth muscle cells (VSMC) and HT-29 cell lines

Ofuegbe¹,

Oyagbemi²,

Omóbòwálé³

et al. 2017

J. Med. Plants Res.

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“…M. charantia induces cell death by activating the caspase-3 enzyme and increase the level of apoptogenic protein and the expression of Bax gene, which induces DNA fragmentation and nuclear condensation [58]. Treatment of fractionated seed extract of M. charantia in human myeloid HL60 cells induced the differentiation and can be used as therapy for leukemia [59]. Pitchakarn et al [60] reported that fresh bitter melon leaf extract significantly decreased the gene expression of MMP-2 and MMP-9 in a breast cancer cell line.…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Nagarani

Abirami

Siddhuraju

2014

Food Science and Human Wellness

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Plants with potential therapeutic values have been used from time immemorial to cure various ailments and infectious diseases. Of late, scientific evidences have been provided on the potential therapeutic agent exhibited by certain traditionally used vegetable extracts. The importance of wild edible plants may be traced to antiquity but systemic studies are recent. All the Momordica species have been consumed as vegetable and traditionally used for various disorders. The whole plant parts are ascribed to possess the anti-diabetic effect in traditional medicinal system. The active constituents of Momordica plant parts were cucurbitane type triterpenoids, phenolics, glycosides, and several kinds of peptides including Momordica anti-HIV protein (MAP 30). Recent reports revealed the presence of several kinds of cucurbitane type triterpenoids in leaf, stem and fruits of Momordica species having several pharmacological activities. There is lack of scientific information available on the wild species which also having several bioactive components with potential activities. So the present review compares and highlights the current knowledge of the nutritional value, phytochemistry and physiological effects of wild species with known variety.

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“…Some pharmacological and safety studies of this herb have been carried out 16,17 . In addition to hypoglycaemic activity, M.charantia has been shown to have antioxidant [18][19][20] , anti-tumour [21][22][23][24][25] , neuroprotective 26 , anti-inflammatory [27][28][29] and antimicrobial activity 30,31 . It has a resistance modifying effect for aminoglycosides against methicillin-resistant Staphylococcus aureus 32 .…”

Section: Introductionmentioning

confidence: 99%

In vivo hypoglycemic effect of methanolic fruit extract of <i>Momordica charantia L</i>

Nkambo¹,

Anyama²,

Onegi³

2014

Afr H. Sci.

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Background: Momordica charantia L. is a medicinal plant commonly used in the management of diabetes mellitus. Objectives: We investigated the blood glucose lowering effect of the methanolic fruit extract of the Ugandan variety of M. charantia L. in alloxan-induced diabetic albino rats. Methods: 500g of M. charantia powder were macerated in methanol and the extract administered to two groups of alloxaninduced diabetic rats. The first group received 125mg/kg, the second 375mg/kg and a third group 7mg/ kg of metformin. A fourth group received 1ml normal saline. Fasting blood glucose (FBG) levels were measured at 0.5,1,2,3,5,8 and 12 hours and compared using one-way ANOVA. Results: There was an initial rise in FBG for 1 hour after administration of extracts followed by steep reductions. Significant reduction in FBG occurred at 2 hours for 125mg/kg of extract (-3.2%, 313±25.9 to 303±25.0mg/dL, p = 0.049), 375mg/ kg of extract (-3.9%, 356±19.7 to 342±20.3mg/dL, p = 0.001), and metformin (-2.6%, 344±21.7 to 335±21.1mg/dL, p = 0.003) when compared to normal saline. The maximum percentage reduction in FBG by both extracts occurred between 3 and 12 hours post dose. Conclusions: The methanolic fruit extract of M. charantia exhibits dose dependent hypoglycaemic activity in vivo.

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Antileukemic Potential ofMomordica charantiaSeed Extracts on Human Myeloid Leukemic HL60 Cells

Cited by 18 publications

References 41 publications

Anti-proliferative and cytotoxic effects of methanol extract of the leaves of Momordica charantia L. (Cucurbitaceae) on vascular smooth muscle cells (VSMC) and HT-29 cell lines

Anti-proliferative and cytotoxic effects of methanol extract of the leaves of Momordica charantia L. (Cucurbitaceae) on vascular smooth muscle cells (VSMC) and HT-29 cell lines

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

In vivo hypoglycemic effect of methanolic fruit extract of <i>Momordica charantia L</i>

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