Antileukemic effects of Didemnum psammatodes (Tunicata: Ascidiacea) constituents

Takeara, Renata; Jimenez, Paula Christine; Wilke, Diego Veras; Moraes, Manoel Odoríco de; Pessoa, Cláudia; Lopes, Norberto Peporine; Lopes, João Luís Callegari; Lotufo, Tito Monteiro da Cruz; Costa-Lotufo, Letı́cia V.

doi:10.1016/j.cbpa.2007.02.011

Cited by 32 publications

(30 citation statements)

References 24 publications

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“…In particular, a methyl esters mixture containing methyl palmitate and methyl stearate was investigated for mechanisms involved in the cytotoxic activity. This mixture was more active than single standards against all tested cell lines such as acute promyeloblastic leukemia HL-60, chronic myelogenic leukemia K-562, lymphoblastic leukemia CEM, and T-cell leukemia MOLT-4 (Takeara et al, 2007).…”

Section: Resultsmentioning

confidence: 93%

“…One molecular target of palmitic acid in tumour cells is DNA topoisomerase I, however, interestingly, it does not affect DNA topoisomerase II, suggesting that palmitic acid may be a lead compound of anticancer drugs (Harada et al, 2002). Recently, the in vitro cytotoxic activity of fatty acids and methyl esters against various cancer cells was reported (Takeara et al, 2007;Yoo et al, 2007). In particular, a methyl esters mixture containing methyl palmitate and methyl stearate was investigated for mechanisms involved in the cytotoxic activity.…”

Section: Resultsmentioning

confidence: 99%

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In vitro Cytotoxic Activity of Salsola oppositifolia Desf. (Amaranthaceae) in a Panel of Tumour Cell Lines

Tundis

Loizzo

Bonesi

et al. 2008

Zeitschrift Für Naturforschung C

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The aim of the present study was to evaluate for the first time the in vitro cytotoxic activity of fractions and isolated flavonols from Salsola oppositifolia Desf. (Amaranthaceae). The nhexane fraction demonstrated an effective cytotoxic activity on the large lung carcinoma and amelanotic melanoma cell lines with IC 50 values of 19.1 μg/ml and 24.4 μg/ml, respectively. Also the dichloromethane fraction exhibited cytotoxic activity against COR-L23 (IC 50 30.4 μg/ml) and C32 (IC 50 33.2 μg/ml) cells, while the EtOAc fraction demonstrated a selective cytotoxic activity against MCF-7 cells (IC 50 67.9 μg/ml). The major active constituents of this fraction were isorhamnetin-3-O-glucoside (1) and isorhamnetin-3-O-rutinoside (2), which showed an interesting activity against the cell line MCF-7 with IC 50 values of 18.2 and 25.2 μg/ml, respectively. Compound 2 exhibited a strong activity against the hormonedependent prostate carcinoma LNCaP cell line with an IC 50 of 20.5 μg/ml. Constituents of S. oppositifolia were identified by GC-MS and NMR analyses.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

In vitro Cytotoxic Activity of Salsola oppositifolia Desf. (Amaranthaceae) in a Panel of Tumour Cell Lines

Tundis

Loizzo

Bonesi

et al. 2008

Zeitschrift Für Naturforschung C

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“…This extract was tested on HL-60 promyeloblastic leukemia cells, with results suggesting that cytotoxicity is related to initiation of apoptosis in these cells. Takeara et al [27] demonstrated that compounds found in the methanol extract of Didemnum psammatodes show cytotoxic activity and antileukemic effects. Interestingly, these molecules also exhibited antiproliferative activity.…”

Section: Cytoxicitymentioning

confidence: 99%

Tunicates: A Vertebrate Ancestral Source of Antitumor Compounds

Cooper

Albert

2014

Handbook of Anticancer Drugs From Marine Origin

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An alarming increase in cancer deaths around the globe has sparked a quest for new effective antitumor drugs developed through biological screening of both terrestrial and marine organisms. Recently, analyses of marine-derived alkaloids isolated from tunicates, a close relative to vertebrates, reveal various anti-cancer activities including anti-angiogenic action, anti-proliferative activity, inhibition of key cellular events like topoisomerase function and tubulin polymerization with respect to cytotoxicity and apoptosis. Vast numbers of potential anticancer molecules in the marine biosphere cannot be underestimated. Tunicate compounds have already entered the market and shown significant success. Moreover, improved technology has enabled synthesis of these molecules by a diverse cadre of professionals including career biologists, immunobiologists, invertebrate immunologists, and marine biologists who use an amazing array of procedures. Although there are no guarantees of consistently reliable success, identifying and comprehending the basic nature of these compounds is a promising first step towards unique pharmaceutical designs that promise to provide a therapeutic solution.

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“…A mixture of methyl palmitate and methyl stearate was investigated for mechanisms involved in their cytotoxic activity. This mixture was more active than single standards against all tested cell lines such as acute promyeloblastic leukemia HL-60, chronic myelogenic leukemia K-562, lymphoblastic leukemia CEM, and T-cell leukemia MOLT-4 cells [40].…”

mentioning

confidence: 92%

“…g-Tocopherol was active against renal cell carcinoma and prostate carcinoma cells with IC 50 values of 10.4 and 11.8 mg/ml, respectively. Moreover, the in vitro cytotoxic activity of fatty acids and methyl esters was recently reported [40] [41]. A mixture of methyl palmitate and methyl stearate was investigated for mechanisms involved in their cytotoxic activity.…”

mentioning

confidence: 99%

In vitro Cytotoxic Activity of Extracts and Isolated Constituents of Salvia leriifoliaBenth. against a Panel of Human Cancer Cell Lines

Tundis

Loizzo

Bonesi

et al. 2011

Chemistry & Biodiversity

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In the course of recent efforts to identify new potential antiproliferative active principles, Salvia leriifolia extracts and isolated constituents were evaluated for their cytotoxic activity against a panel of human cancer cell lines, including renal adenocarcinoma (ACHN), amelanotic melanoma (C32), colorectal adenocarcinoma (Caco-2), lung large cell carcinoma (COR-L23), malignant melanoma (A375), lung carcinoma (A549), and hepatocellular carcinoma (Huh-7D12) cells. The hexane and CH(2) Cl(2) extracts showed the strongest cytotoxic activity against the C32 cell line with IC(50) values of 11.2 and 13.6 μg/ml, respectively, and the AcOEt extract was the most active extract against the COR-L23 cell line (IC(50) of 20.9 μg/ml). Buchariol, a sesquiterpene obtained by biofractionation of the CH(2) Cl(2) extract, exhibited a higher activity than the positive control vinblastine against the C32 and A549 cell lines (IC(50) values of 2.1 and 12.6 μM, resp.). Interesting results were also obtained for naringenin, a flavonoid isolated from the AcOEt extract, which exhibited a strong cytotoxic activity against the C32, LNCaP, and COR-L23 cell lines (IC(50) values of 2.2, 7.7, and 33.4 μM, resp.), compared to vinblastine (IC(50) values of 3.3, 32.2, 50.0 μM, resp.). None of the tested compounds affected the proliferation of skin fibroblasts (142BR), suggesting a selective activity against tumor cells.

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Antileukemic effects of Didemnum psammatodes (Tunicata: Ascidiacea) constituents

Cited by 32 publications

References 24 publications

In vitro Cytotoxic Activity of Salsola oppositifolia Desf. (Amaranthaceae) in a Panel of Tumour Cell Lines

In vitro Cytotoxic Activity of Salsola oppositifolia Desf. (Amaranthaceae) in a Panel of Tumour Cell Lines

Tunicates: A Vertebrate Ancestral Source of Antitumor Compounds

In vitro Cytotoxic Activity of Extracts and Isolated Constituents of Salvia leriifoliaBenth. against a Panel of Human Cancer Cell Lines

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