Antileishmanial effects of γCdcPLI, a phospholipase A2 inhibitor from Crotalus durissus collilineatus snake serum, on Leishmania (Leishmania) amazonensis
Marina Neves Gonçalves,
Daiana Silva Lopes,
Samuel Cota Teixeira
et al.
Abstract:BACKGROUND Leishmaniasis, a neglected disease caused by the parasite Leishmania, is treated with drugs associated with high toxicity and limited efficacy, in addition to constant reports of the emergence of resistant parasites. In this context, snake serums emerge as good candidates since they are natural sources with the potential to yield novel drugs.OBJECTIVES We aimed to show the antileishmanial effects of γCdcPLI, a phospholipase A 2 inhibitor from Crotalus durissus collilineatus snake serum, against Leis… Show more
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