Antileishmanial and immunomodulatory activity of <i>Xylopia discreta</i>

López, R.; Suárez, Luís Enríque Cuca; Delgado, Gabriela

doi:10.1111/j.1365-3024.2009.01134.x

Cited by 26 publications

(18 citation statements)

References 24 publications

(27 reference statements)

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“…They are sustainable, economical, available and more importantly have immunomodulatory effects compared with common antileishmanial compounds . These herbal extracts can be utilized as alternative natural treatments for cancers and serious infectious diseases such as CL, in which the host immune responses are critical for evolution of the disease …”

Section: Introductioncontrasting

confidence: 56%

Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis

Heidari‐Kharaji

Omrani

Badirzadeh

et al. 2018

Parasite Immunology

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Summary This is the first study aiming to determine the therapeutic effects of the Sambucus ebulus aquatic extract as an antileishmanial herbal drug and evaluate the immune responses in Leishmania major major infected BALB/c mice. The antileishmanial activity of S ebulus aquatic extract was evaluated using MTT test as well as parasite rescue and transformation assay. Footpad swelling and parasite load of infected mice were measured by several techniques. The immune responses were evaluated by measuring the levels of IFN‐γ, IL‐4, nitric oxide and arginase. The results indicated that S. ebulus can significantly decrease L. major promastigotes and amastigotes viability, but it was not toxic to macrophages. The lesion size, parasite burden and the level of ARG decreased in the treated infected mice, while the IFN‐γ‐to‐IL‐4 ratio and the level of NO increased significantly. Altogether, the S. ebulus extract is an effective compound for killing Leishmania parasite without excessive toxicity to the host cells and can cure the CL by switching the host immune responses towards Th1 response. Thus, it may be a perfect therapeutic option for CL treatment.

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Section: Introductioncontrasting

confidence: 56%

Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis

Heidari‐Kharaji

Omrani

Badirzadeh

et al. 2018

Parasite Immunology

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“…was evaluated on J774 and on U937 cells infected with L. panamensis and presented IC 50 of 6.35 ± 4.00 μg/mL and 6.25 ± 1.1 μg/mL respectively. The cytotoxicities were evaluated on J774 (IC 50 = 698.45 ± 98 μg/mL) and on U937 (IC 50 = 160.0 ± 8.7 μg/mL) (Lopez et al, 2009).…”

Section: Annonaceaementioning

confidence: 99%

Anti‐Parasitic Activity of Essential Oils and their Active Constituents against Plasmodium, Trypanosoma and Leishmania

Béro

Kpoviessi

Quetin-Leclercq

2014

Novel Plant Bioresources

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“…5) More than 98% cases in Colombia are caused by cutaneous Leishmaniasis, being mostly transmitted by Leishmania (Viannia) panamensis (L. (V.) panamensis) species. 6) At clinical level, 20% of cases are neither reported nor treated; furthermore, nearly 80% of infections are spontaneously resolved due to the host's immunological response against parasites. 7) Clinical cases which cannot be immunologically resolved are often treated by first-line drugs (e.g.…”

mentioning

confidence: 99%

seco-Limonoids and Quinoline Alkaloids from Raputia heptaphylla and Their Antileishmanial Activity

Barrera

Coy-Barrera

Granados-Falla

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Regular ArticleThe Rutaceae family, consisting of ca. 150 genera and 1600 species, is mostly distributed throughout tropical regions. Species from this family have important uses in industry such as in food, pharmaceuticals and ornamental purposes, as well as having a wide variety of ethnobotanical uses 1) ; they are studied in terms of obtaining alkaloids and limonoids as bioactive principles.2) Among important plants from Rutaceae, those from the Raputia genus have attracted special attention because of their use in South-America due to their trypanocidal and leishmanicidal properties. 3)Leishmaniasis is an endemic disease which affects nearly 12 million people worldwide in tropical and subtropical regions.4) Clinically, the disease compromises skin, mucosa, and/or visceral organs and its specific action depends on both the species involved and the host's immunological system. Cutaneous and mucocutaneous varieties are often disabling, having high morbidity rates, whereas the visceral type affects a smaller number of people.5) More than 98% cases in Colombia are caused by cutaneous Leishmaniasis, being mostly transmitted by Leishmania (Viannia) panamensis (L. (V.) panamensis) species. 6) At clinical level, 20% of cases are neither reported nor treated; furthermore, nearly 80% of infections are spontaneously resolved due to the host's immunological response against parasites.7) Clinical cases which cannot be immunologically resolved are often treated by first-line drugs (e.g. pentavalent antimonial salts) which have shown higher toxicity and parasite-induced resistance. This had consequently led to the search and development of novel therapeutic agents for controlling this disease. Hence, studying the active principles obtained from traditional medicinal plants still has special importance.8) As part of our research into bioactive compounds from Rutaceae plants, this article thus describes the isolation, elucidation and antileishmanial activity of a novel seco-limonoid (1) and two novel alkaloids (2-3), along with other six known compounds [a seco-limonoid (4) and five alkaloids (5-9)] obtained from Raputia heptaphylla stem bark and leaves. The antileishmanial effect of isolated compounds was evaluated on L. (V.) panamensis (promastigotes and amastigotes). Compounds 1 and 5 revealed important antileishmanial activity at different levels. Results and DiscussionEthanol extract from R. heptaphylla (20 g) stem bark was subjected to an ultrasound-assisted acid-base extraction for alkaloids 9,10) affording an alkaloid extract (1.2 g). Chloroform-soluble extract was purified by repeated CC on silica gel to give compounds 1-4. Alkaloids 5-9 were also isolated using an identical procedure on ethanol extract from R. heptaphylla leaves (50 g). Structures were established on the basis of full spectroscopic data analysis compared to data from the pertinent literature (Fig. 1).Compound 1 was obtained as colorless crystals (mp 220-222°C, MeOH). Its high resolution-electrospray ionization mass spectra (HR-ESI-MS) showed a pseud...

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Antileishmanial and immunomodulatory activity of Xylopia discreta

Cited by 26 publications

References 24 publications

Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis

Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis

Anti‐Parasitic Activity of Essential Oils and their Active Constituents against Plasmodium, Trypanosoma and Leishmania

seco-Limonoids and Quinoline Alkaloids from Raputia heptaphylla and Their Antileishmanial Activity

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