Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits

Ferreira, Maria Goretty P. R.; Kayano, Anderson M.; Silva, Alexandre de Almeida e; Silva, Tatiany O. da; Zuliani, Juliana Pavan; Facundo, Valdir Alves; Calderon, Leonardo de Azevedo; Almeida-e-Silva, Alexandre de; Ciancaglini, Pietro; Stábeli, Rodrigo G.

doi:10.1590/s0102-695x2010005000033

Cited by 25 publications

(22 citation statements)

References 16 publications

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“…This behavior has been explored for the efficient delivery of antiparasitic drugs for treating infections in these cells (Aqil et al 2013). In this context, for example, plants from genus Piper have been investigated as a source of new natural products with potential antitumoral, antifungal, antiplasmodial, antioxidant and tripanocidal properties (da Silva et al 2014), as well as antimicrobial, antipyretic, aromatic, emetic, diuretic, hallucinogen, ornamental and insect repellent roles, among other applications (Parmar et al 1997;Wadt et al 2004;Ferreira et al 2010). Many components have been isolated from Piper plants, such as terpenes, phenylpropenoids, lignans, neolignans, steroids, benzopyrans, chalcones, flavones, other phenolic compounds and a series of alkaloids (Parmar et al 1997;Wadt et al 2004;Felipe et al 2007).…”

Section: Liposomal Systems As Carriers For Bioactive Compoundsmentioning

confidence: 99%

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Liposomal systems as carriers for bioactive compounds

et al. 2015

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Since the revolutionary discovery that phospholipids can form closed bilayered structures in aqueous systems, the study of liposomes has become a very interesting area of research. The versatility and amazing biocompatibility of liposomes has resulted in their wide-spread use in many scientific fields, and many of their applications, especially in medicine, have yielded breakthroughs in recent decades. Specifically, their easy preparation and various structural aspects have given rise to broadly usable methodologies to internalize different compounds, with either lipophilic or hydrophilic properties. The study of compounds with potential biotechnological application(s) is generally related to evaluation and risk assessment of the possible cytotoxic or therapeutic effects of the compound under study. In most cases, undesirable sideeffects are associated with an interaction of the liposome with the cell membrane and/or its absorption and subsequent interaction with a cellular biomolecule. Liposomal carrier systems have an unprecedented potential for delivering bioactive substances to specific molecular targets due to their biocompatibility, biodegradability and low toxicity. Liposomes are therefore considered to be an invaluable asset in applied biotechnology studies due to their potential for interaction with both hydrophilic and lipophilic compounds.

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Section: Liposomal Systems As Carriers For Bioactive Compoundsmentioning

confidence: 99%

“…The 3-(3,4,5-trimethoxyphenyl) propanoic acid extracted from P. tuberculatum Jacq. has been found to have potential leishmanicidal activity (Facundo et al 2008;Ferreira et al 2010;Barros et al 2013). Leishmaniasis is endemic in more than 98 countries and territories.…”

Section: Liposomal Systems As Carriers For Bioactive Compoundsmentioning

confidence: 99%

Liposomal systems as carriers for bioactive compounds

et al. 2015

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“…arboreum e P. tuberculatum são tradicionalmente usados para fins medicinais diversos (Regasini et al 2009;Ferreira et al 2010;Paes-Gonçalves et al 2012). Investigações fitoquímicas dessas espécies identificaram compostos fixos e voláteis como alcaloides, terpenos e fenólicos (Parmar et al 1997;Facundo et al 2008;Andrade et al 2009;Regasini et al 2009).…”

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“…Atividades antileishmaniose, trypanocida e antifúngica são citadas para P. arboreum var. arboreum e P. tuberculatum, e propriedades inseticida, larvicida, citotóxica, antitumoral, sedativa, analgésica, hipotensiva, ansiolítica, anticonvulsivante e antiagregação plaquetária são mencionadas para P. tuberculatum ( Regasini et al 2009;Ferreira et al 2010;Trindade et al 2012).…”

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Caracterização farmacognóstica de Piper arboreum var. arboreum e P. tuberculatum (Piperaceae)

et al. 2016

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RESUMOPiper arboreum Aubl. var. arboreum e P. tuberculatum Jacq. (Piperaceae), conhecidas como pimenta-longa, são comercializadas como produtos tradicionais fitoterápicos e, frequentemente, identificadas erroneamente, não havendo relatos sobre controle de qualidade dessas espécies. O objetivo do trabalho foi preparar e caracterizar drogas vegetais foliares e caulinares dessas espécies para estabelecer-lhes parâmetros de autenticidade botânica e grau de pureza para o controle de qualidade. Foram utilizados métodos padrões para o preparo e análises estrutural e físico-química das drogas vegetais. São caracteres diagnósticos macroscópicos para distinguir as drogas vegetais íntegras: tamanho, forma, cor, sabor, textura, características da superfície de fratura e da secção transversal e os padrões de venação foliar. São caracteres diagnósticos para distinguir as drogas vegetais pulverizadas: padrões de cutícula e cera epicuticular, tipos de tricoma e espessamento parietal dos elementos traqueais e a forma do hilo dos grãos de amido. Emergências são marcadores morfológicos chave para as drogas vegetais de P. tuberculatum. Os valores dos parâmetros físico-químicos foram similares nas drogas vegetais das espécies, exceto o de cinzas ácido-insolúveis que foi maior nas drogas vegetais caulinares de P. arboreum var. arboreum. As maiores concentrações de metais ocorreram nas drogas vegetais de P. arboreum var. arboreum. As concentrações mais elevadas foram de Al, Cu, Mn e V e as mais baixas de Cd, Co e Hg. Os resultados obtidos poderão ser utilizados como parâmetros de controle de qualidade para as drogas vegetais de ambas as espécies. PALAVRAS-CHAVE: Pimenta-longa, Produtos tradicionais fitoterápicos, Farmacognosia, Metais tóxicos, ICP-OES. Pharmacognostical characterization of Piper arboreum var. arboreum and P. tuberculatum (Piperaceae)ABSTRACT Piper arboreum Aubl. var. arboreum and P. tuberculatum Jacq. (Piperaceae), both known as "pimenta-longa", are frequently misidentified. Despite the fact that both species are sold as traditional phytotherapeutic products, there are no reports on their quality control. The aim of this study was to prepare and characterize leaf and stem herbal drugs of both species using standard methods aiming to establish parameters for botanical authentication and purity degree for their quality control. Size, shape, color, taste, texture, fracture surface and transection characteristics, and leaf venation patterns are macroscopic diagnostic characters useful to distinguish the herbal drugs when they are not powdered. The following characters are useful for diagnostic purposes of the powdered herbal drugs: cuticular and epicuticular wax patterns, types of trichomes, and wall thickening of the tracheary elements, and shape of the hilum of the starch grains. Emergences are key morphological markers for P. tuberculatum herbal drugs. Physicochemical parameter values were similar in herbal drugs of both species, except acid-insoluble ash value which was higher in the P. arboreum var. arboreum stem her...

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“…Diversos trabalhos relatam a atividade desses compostos como agentes antimicrobianos, antifúngicos, antivirais, antialérgicos, antiespasmódico, anti-inflamatório, imunomoduladores, além dos efeitos na prevenção e terapia de diversos tipos de câncer (BARDON et al, 2002;PEANA et al, 2003, PADUCH et al, 2007. Uma variedade de terpenos e seus derivados sintéticos têm sido descritos ainda, como agentes antiparasitários com alta eficácia e seletividade especialmente pela ação leishmanicida, antimalárica e tripanocida (ARAYA et al, 2003;KAYSER et al, 2003;MAYA et al, 2007;CUNHA et al, 2003;GERSHENZON, DUDAREVA, 2007;FERREIRA et al, 2010;ABDEL-SATTAR et al, 2010;OTOGURO et al, 2011. IZUMI et al, 2013 O sesquiterpeno Artemisinina e seus derivados representam uma classe potente de antimaláricos amplamente utilizados em todo o mundo (ECKSTEIN-LUDWIG et al, 2003;KAYSER et al, 2003).…”

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Determinação do potencial tripanocida de derivados do ácido copálico

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Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits

Cited by 25 publications

References 16 publications

Liposomal systems as carriers for bioactive compounds

Liposomal systems as carriers for bioactive compounds

Caracterização farmacognóstica de Piper arboreum var. arboreum e P. tuberculatum (Piperaceae)

Determinação do potencial tripanocida de derivados do ácido copálico

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