Antiischemic activity of immobilized cytochrome C

It is demonstrated that energostim, an aqueous mixture of NAD § cytochrome c, and inosine possesses pronounced antihypoxic activity. Energostim increases by 26-fold the survival rate of rats with low resistance to hypoxia under conditions of hypobaric hypoxia. Administration of energostim before the "rise" in a pressure chamber prevents a decrease in the brain content of ATP in rats with high resistance to hypoxia under the conditions of maximum hypoxia and increases it in rats with low resistance to hypoxia. Energostim has no effect on the survival rate of high-resistant rats in acute hypobaric hypoxia and on the brain content of macroergic substances in low-and high-resistant rats when agony is not developed on "the critical height" and there is no deficiency of macroergic substances.

show abstract

Energizing and antihypoxic effects of energostim

Luk’yanova

Dudchenko

Romanova

et al. 1997

Bull Exp Biol Med

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Antiischemic activity of immobilized cytochrome C

Abstract: The antiischemic activity of polyethylene glycol-and dialdehyde dextran-immobilized cytochrome C is experimentally studied on rats. Immobilization of cytochrome C on these matrices enhanced the enzyme activity assayed by restriction of the necrotic zone 4 hours after coronary occlusion.

Cited by 1 publication

References 3 publications

Energizing and antihypoxic effects of energostim

Energizing and antihypoxic effects of energostim

Contact Info

Product

Resources

About