Antiinflammatory effects of some copper complexes

Abstract

Copper complexes of a range of ligands have been prepared and evaluated for antiinflammatory activity and irritancy after oral, subcutaneous, and local administration in rats and guinea pigs. The antiinflammatory activities were found to depend on the species used and the route of administration. When nonantiinflammatory ligands were used, the response was generally dose dependent. With D-penicillamine and when the ligands were themselves antiinflammatory in animal models of inflammation--as was the case with flufenamic acid, levamisole, aspirin, L-histidine, and 2-amino-2-thiazoline--differences in antiinflammatory activity were observed between the copper complexes and the free ligands. In some cases, the copper complexes were the more effective. There was a weak correlation between local (subplantar) irritation and the dose of copper but, for four compounds studied in more detail, the response in the local subplantar test and degree of antiinflammatory activity were not related, suggesting that the action of copper is not solely by a counterirritant mechanism. No obvious differences between the activities of copper(I) and copper(II) compounds were observed, suggesting that a common metabolite may be involved in the antiinflammatory action of copper.

Spectroscopic, Thermal and Biological Studies of the Coordination Compounds of Sulfasalazine Drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) Transition Metal Complexes

“…Probably the most widely studied cation in this respect is Cu(II), since a host of low-molecular-weight copper complexes have been proven beneficial against several diseases such as tuberculosis, rheumatoid, gastric ulcers, and cancers. [11][12][13][14] In the literature survey, there is little attention concerning the mode of coordination of H 3 Suz with metal ions. Previous studies [15][16][17][18][19][20][21][22] of the complexation of sulfa drugs did not focus on the coordination behavior, but only dealt with the solution state and crystal structures of its metal complexes.…”

Determination of thermodynamic stability constant of bivalent transition metal complexes with schiffs base as ligands

“…The values of stepwise stability constants and over all stability constants are given in Table No. This is natural order given by Irving -William 15 . A theoretical justification of the order of stability constants follows from the consideration of the reciprocal of the ionic radii and 2 nd ionization enthalpy of metal.…”

Physico – Chemical Study of Transition Metal Complexes with Schiff’s Base derived from Naphthaldehyde and Substituted Aromatic Amines

“…[1][2][3][4] Schiff's base offer a versatile and flexible series of ligands capable to bind with variety of metal ions to give complexes with varying properties. These complexes are biologically active 5 and have wide potential applications in many fields such as catalysis 6 , electrochemistry 7 and medicines Studies 8 have shown that metal complexes act as antitumour, antiviral, anti cancer 10 and other many anti bacterial agents.…”