Antiinflammatory effects of lycorine and haemanthidine

Çitoğlu, Gülçin Saltan; Tanker, Metin; Gümüşel, Bülent

doi:10.1002/(sici)1099-1573(199805)12:3<205::aid-ptr203>3.0.co;2-7

Cited by 58 publications

(34 citation statements)

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“…caranine, crinine, galanthamine and galanthine 31,32 . Haemanthidine and lycorine are also analgesics and antiinflammatory with activities greater than aspirin 33 and indomethacin 34 , respectively, while narwedine and vittatine could potentiate the analgesic effects of caffeine and morphine 33 .…”

Section: Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

Untitled

2013

IJPSR

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Section: Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

Untitled

2013

IJPSR

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“…It has been reported as a potent inhibitor of ascorbic acid synthesis, cell growth and division and organogenesis in higher plants, algae, and yeasts, inhibiting the cell cycle during the interphase (Bastida et al, 2006). Additionally, lycorine exhibits antiviral (against poliovirus, vaccine smallpox virus and SARS-associated coronavirus), antifungal (Saccharomyces cerevisiae, Candida albicans), and anti-protozoan (Trypanosoma brucei) activities (McNulty et al, 2009), and is more potent than indomethacin as an anti-inflammatory agent (Citoglu et al, 1998). Lycorine has also been shown to have insect antifeedant activity (Evidente et al, 1986).…”

Section: Lycorine-typementioning

confidence: 99%

The Genus Galanthus: A Source of Bioactive Compounds

Berkov¹,

Codina²,

Bastida³

2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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“…14,15 Alkaloids including lycorine, homolycorine, haemanthidine, haemanthamine, 6α-and 6β-hydroxy-haemanthamine, and tazettine have been isolated from Sternbergia species. [14][15][16][17][18] It has been reported that Sternbergia species contain especially crinine-type and lycorine-type Amaryllidaceae alkaloids. 13 In order to investigate new sources for galantamine, Sternbergia species were investigated using HPLC in the current study.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Galantamine in <i>Sternbergia</i> Species by High Performance Liquid Chromatography

Açıkara

Yılmaz

Yazgan

et al. 2019

tjps

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ÖZAmaç: Bu çalışmada Türkiye'de yetişen Sternbergia türlerinin galantamin içeriklerinin kalitatif ve kantitatif analizi amaçlanmıştır. Gereç ve Yöntemler:Galantamin Sternbergia fischeriana yumrularından izole edilmiş ve yapısı spektroskopik yöntemler kullanılarak aydınlatılmıştır.Sternbergia lutea subsp. lutea, S. lutea subsp. sicula, Sternbergia candida, S. fischeriana ve Sternbergia clusiana türlerinin galantamin içeriği kalitatif ve kantitatif olarak yeni geliştirilen ve valide edilmiş bir yüksek performanslı sıvı kromatografisi (HPLC) yöntemi kullanılarak yapılmıştır. Bulgular: S. lutea subsp. sicula türünün 0.0165±0.0002 g/100 g olarak en yüksek galantamin içeriğine sahip olduğu belirlenmiştir. Galantamin için saptama ve kantifikasyon sınırı değerleri sırasıyla 7.5 μg ve 25 μg olarak belirlenmiştir.Sonuç: Türkiye'de yetişen S. fischeriana türünden galantamin izolasyonu ilk kez bu çalışma ile rapor edilmiştir. Ayrıca bu çalışma ile Sternbergia türlerinin galantamin içeriğinin tespit edilmesi ve miktar tayini için yeni bir HPLC metodu geliştirilmiştir. Anahtar kelimeler: Galantamin, HPLC, Sternbergia spp.Objectives: This study describes the qualitative and quantitative analysis of galantamine in Sternbergia species growing in Turkey. Materials and Methods:Galantamine was isolated from Sternbergia fischeriana bulbs and the structure of the compound elucidated by spectroscopic methods. The qualitative and quantitative analysis of galantamine was investigated in Sternbergia lutea subsp. lutea, S. lutea subsp. sicula, Sternbergia candida, S. fischeriana, and Sternbergia clusiana using a specially developed and validated high performance liquid chromatography (HPLC) method.Results: S. lutea subsp. sicula had the highest content of galantamine, i.e., 0.0165±0.0002 g/100 g. The limits of detection and quantification were 7.5 μg and 25 μg, respectively. Conclusion:Isolation of galantamine from S. fischeriana growing in Turkey is reported for the first time. An HPLC method was developed for identification and quantification of galantamine in Sternbergia species.

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Antiinflammatory effects of lycorine and haemanthidine

Cited by 58 publications

References 0 publications

Untitled

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The Genus Galanthus: A Source of Bioactive Compounds

Quantification of Galantamine in <i>Sternbergia</i> Species by High Performance Liquid Chromatography

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