Antiinflammatory and antioxidative effects of Agrimonia pilosa Ledeb

Agrimonia pilosa Ledeb.: A review of its traditional uses, botany, phytochemistry, pharmacology, and toxicology

“… in vitro [ 98 ] Anti-inflammatory effects The effect of APL extracted with 80% ethanol on induced nitric oxide synthase and raw 264.7 cells in macrophage line was observed the various solvent extracts of APL, n-butanol fraction showed the most powerful inhibitory ability against nitric oxide (NO) production in LPS-induced RAW 264.7 cells without affecting cell viability. in vitro [ 99 ] Using Raw 264.7 murine macrophages the effects of methanol extract of APL in LPS-induced production of inflammatory mediators were measured. APL attenuated the production of inflammatory mediators such as NO, PGE 2 and pro-inflammatory cytokines in LPS -induced Raw 264.7 cells.…”

“…in vitro [99] Using Raw 264.7 murine macrophages the effects of methanol extract of APL in LPS-induced production of inflammatory mediators were measured.…”

Development and Evaluation of Topical Formulation Containing Agrimonia pilosa Extract

“…Agrimonia pilosa is distributed throughout East Asia and Central Europe and is a widely used traditional medicinal herb owing to its anticancer, antioxidant, and anti-inflammatory properties and beneficial effects on skin inflammation. The herb is reported to contain flavonoid, isocumarin, triterpene, and tannin components and has been used for hemostasis and to treat branch trichomoniasis and malaria [20][21][22][23][24]. Apigenin-7-O-glucuronide (A7OG) and luteolin-7-O-glucuronide(L7OG), a representative flavonoid glucuronides present in A. pilosa (Figure 1), have shown many pharmacological effects, such as anti-inflammatory properties [25][26][27][28][29].…”