Antiinflammatory and antioxidant property of saponins of tea [<i>Camellia sinensis</i> (L) O. Kuntze] root extract

Sur, Pratima; Chaudhuri, T. C.; Vedasiromoni, J. R.; Gomes, Antony; Ganguly, Dilip

doi:10.1002/ptr.696

Cited by 87 publications

(55 citation statements)

References 11 publications

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“…These polyphenolic compounds may also be responsible for the antioxidant activity [28,29]. The presence of saponins may play a role in the observed anti-inflammatory and antioxidant activities [30,31].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of pharmacological activities of methanol extract of Ixora cuneifolia leaves

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Evaluation of pharmacological activities of methanol extract of Ixora cuneifolia leaves

et al. 2016

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“…Saponin has the antioxidant effect [22], antiglycation [22,23], anti-inflammatory [24], surfactant activity due to amphipathic nature [25], complexation with cholesterol and causes hemolysis in erythrocyte on iv, enhance proteins penetration through membranes and augment the cytotoxicity of targeted immunotoxins directed against human cancer cells [26]. Researchers also in line with the present finding where DP had shown to have anticancer and free radical scavenging potency by means of anticancer activity on cell proliferation inhibition and inducing apoptosis of breast cancer cell lines T47D and MCF-7 [21,27,28].…”

Section: Discussionmentioning

confidence: 99%

Study of Dendrophthoe Pentandra Ethyl Acetate Extract as Potential Anticancer Candidate on Safety and Toxicity Aspects

Sul’ain¹,

Yee²,

Fauzi³

et al. 2017

JAPLR

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In the present study, the safety and toxicity of Dendrophthoe pentandra (DP) extracted using ethyl acetate were investigated. DP ethyl acetate (DPEA) extract was screened for its phytochemical constituents using standard procedure and active compounds present in DPEA extract were determined using gas chromatographymass spectrometry (GC-MS), the toxicity of DPEA extract was investigated using brine shrimp lethality assay (BSLA) while the heavy metal content of DP plant was detected using atomic absorption spectrophotometer (AAS) and the cytotoxicity effect of DPEA extract on selected cell lines (HeLa, L929, Glioma, MD-AMB 231, Hep G2 and MCF-7) was determined through MTT assay. The results showed that DPEA extract consist of wide range of bioactive compounds including tannins, saponins, flavonoids and alkaloids. The crude extract contained 1.33% alkaloid, 2.67% flavonoid and 14.87±0.2µg/g total phenolic content. Heavy metals such as copper, zinc and manganese were present below the maximum permissible level. GC-MS result revealed the presence of 39 compounds and out of that, only decanoic acid, palmitic acid, linolenic acid and betasitosterol were suggested to contribute to the medicinal use of DP. The LC 50 of DPEA extract was underdetermined and was predicted above 1000 ppm and DPEA extract showed antiproliferative activity on MCF-7 and L929 with IC 50 of 4.72±0.52µg/ml and 18.12±3.46µg/ml respectively. Thus, the result of the present study revealed that DP plant is relatively safe and can be considered as possible candidates with promising potency to be developed as new chemotherapeutic agent.

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“…SQS is an active component extracted from the Chinese medicinal herb Camellia oleifera Abel and has gained considerable attention due to its wide range of biological and pharmacological properties (19)(20)(21). Previous studies by our group showed that SQS effectively protected against myocardial injury in an isoproterenol-induced rat model of ischemia in vivo and in a hypoxia and reoxygenation model in Langendorff-perfused rat hearts in vitro (8,22,23).…”

Section: Discussionmentioning

confidence: 99%

Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathway

Qiu

Chen

Yan

et al. 2016

Molecular Medicine Reports

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Abstract. Sasanquasaponin (SQS) is an active component ofCamellia oleifera Abel. A recent study by our group demonstrated that SQS was able to inhibit ischemia/reperfusion-induced elevation of the intracellular chloride ion concentration ([Cl -] i ) and exerted cardioprotective effects; however, the underlying intracellular signal transduction mechanisms have yet to be elucidated. As protein kinase C ε (PKCε) is able to mediate Cl -homeostasis, the present study investigated its possible involvement in the effects of SQS on cardiomyocytes subjected to ischemia/reperfusion injury. Cardiomyocytes were pre-treated with or without SQS or SQS plus εV1-2, a selective PKCε inhibitor, followed by simulated ischemia/reperfusion (sI/R). The effects on cell viability, PKCε phosphorylation levels, [Cl -] i , mitochondrial membrane potential and reactive oxygen species (ROS) production were assessed using an MTS assay, western blot analysis, colorimetric assays and flow cytometry. The results revealed that treatment with SQS prior to sI/R increased the viability of cardiomyocytes, and efficiently attenuated lactate dehydrogenase and creatine phosphokinase release induced by sI/R. In addition, SQS promoted PKCε phosphorylation and inhibited sI/R-induced elevation of [Cl -] i , paralleled by the attenuation of mitochondrial membrane potential loss and ROS generation. However, when the cardiomyocytes were treated with εV1-2 prior to SQS pre-conditioning, the cardioprotection induced by SQS was reduced and the inhibitory effects of SQS on sI/R-induced elevation of [Cl -] i , production of ROS and loss of mitochondrial membrane potential were also attenuated. These findings indicated that SQS may inhibit sI/R-induced elevation of [Cl -] i through the PKCε signaling pathway to elicit cardioprotection in cultured cardiomyocytes.

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Antiinflammatory and antioxidant property of saponins of tea [Camellia sinensis (L) O. Kuntze] root extract

Cited by 87 publications

References 11 publications

Evaluation of pharmacological activities of methanol extract of Ixora cuneifolia leaves

Evaluation of pharmacological activities of methanol extract of Ixora cuneifolia leaves

Study of Dendrophthoe Pentandra Ethyl Acetate Extract as Potential Anticancer Candidate on Safety and Toxicity Aspects

Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathway

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