Antiinflammatory and Antihyperalgesic Activity of C-Phycocyanin

Shih, Chao-Ming; Cheng, Shin‐Nan; Wong, Chih‐Shung; Kuo, Yu-Ling; Chou, Tz-Chong

doi:10.1213/ane.0b013e318193e919

Cited by 111 publications

(52 citation statements)

References 29 publications

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“…Pre-or post-treatment with PC significantly attenuated carrageenan-induced inflammatory nociception and the induction of iNOS and COX-2 accompanied by an inhibition of the formation of TNF-␣, E 2 and myeloperoxidase activity (Shih et al, 2009). PC also reduced the levels of TNF-␣ in the blood serum of mice treated with endotoxin and it showed neuroprotective effects in rat cerebellar granule cell cultures and in kainate-induced brain injury in rats (Romay et al, 2003).…”

Section: Discussionmentioning

confidence: 87%

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Sun

Zhang²,

Yan³

et al. 2011

Environmental Toxicology and Pharmacology

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Section: Discussionmentioning

confidence: 87%

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Sun

Zhang²,

Yan³

et al. 2011

Environmental Toxicology and Pharmacology

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“…36,37 Specimens injected with CFA and treated with SP showed reduced body temperature in comparison to the positive control group. This is probably due to the inhibition of a temperature-regulating cytokine 38 or to the arachidonic acid pathway being disabled by suppression of the enzyme COX-2 and, therefore, impairment also of prostaglandin synthesis, 23 as a result of nutritional components and algal pigments such as phycocyanin and c-linolenic acid.…”

Section: Discussionmentioning

confidence: 99%

“…A carrageenan-induced hyperalgesia model has revealed that C-phycocyanin by itself has anti-inflammatory activity since it reduced TNF-a levels and myeloperoxidase activity, selectively inhibiting key enzymes of the acute inflammatory process such as COX-2 and iNOS. 38 In a chronic inflammatory process such as RA, the antioxidant defense system of the body is compromised. There is a decrease in reduced glutathione (GSH) levels as well as in the activity of antioxidant enzymes-superoxide dismutase (SOD), catalase, and glutathione peroxidase-and therefore increased LPO, suggesting increased oxidative damage induced at the joint level and detected at the system level.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effect ofSpirulina (Arthrospira) maximaon Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats

Gutiérrez-Rebolledo¹,

Galár-Martínez²,

García-Rodríguez

et al. 2015

Journal of Medicinal Food

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One of the major mechanisms in the pathogenesis of chronic inflammation is the excessive production of reactive oxygen and reactive nitrogen species, and therefore, oxidative stress. Spirulina (Arthrospira) maxima has marked antioxidant activity in vivo and in vitro, as well as anti-inflammatory activity in certain experimental models, the latter activity being mediated probably by the antioxidant activity of this cyanobacterium. In the present study, chronic inflammation was induced through injection of Freund's complete adjuvant (CFA) in rats treated daily with Spirulina (Arthrospira) maxima for 2 weeks beginning on day 14. Joint diameter, body temperature, and motor capacity were assessed each week. On days 0 and 28, total and differential leukocyte counts and serum oxidative damage were determined, the latter by assessing lipid peroxidation and protein carbonyl content. At the end of the study, oxidative damage to joints was likewise evaluated. Results show that S. maxima favors increased mobility, as well as body temperature regulation, and a number of circulating leukocytes, lymphocytes, and monocytes in specimens with CFA-induced chronic inflammation and also protects against oxidative damage in joint tissue as well as serum. In conclusion, the protection afforded by S. maxima against development of chronic inflammation is due to its antioxidant activity.

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“…Os efeitos farmacológicos das cianobactérias são utilizados para promovê-las comercialmente (Gantar & Svircev, 2008), com destaque para a estimulação do sistema imunológico e da microbiota intestinal, atividades antibacteriana, antitumoral, anti-inflamatória, anti-hiperalgésica e antioxidante, eficácia no tratamento de alergias, anemia e ainda sobre os efeitos tóxicos de radiação (Gantar & Svircev, 2008;Kaushik & Chauhan, 2008;Shih et al, 2009).…”

Section: (Recebido Em 16 De Setembro De 2010 E Aprovado Em 11 De Noveunclassified

Teores de β-caroteno em suplementos e biomassa de Spirulina

et al. 2011

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INTRODUÇÃOOs povos ocidentais têm usado cianobactérias como parte de sua dieta por séculos. As microalgas comercializadas como suplemento alimentar podem ser coletadas diretamente do ambiente onde elas se desenvolvem naturalmente ou podem ser cultivadas sob condições controladas. Nos últimos anos, houve avanços significativos no cultivo de microalgas cujos reflexos podem ser percebidos em sua aplicação na aquicultura, alimentação humana, produção e extração de pigmentos, fertilizantes, biocombustíveis e metabólitos primários e secundários como toxinas, enzimas e vitaminas (Brennam & Owende, 2010). TEORES DE -CAROTENO EM SUPLEMENTOS E BIOMASSA DE Spirulina RESUMOA cianobactéria Spirulina tem sido utilizada há séculos, tendo em vista suas propriedades nutricionais e medicinais. Neste trabalho, objetivou-se analisar os teores de -caroteno tanto em suplementos alimentares a base de Spirulina comercializados em estabelecimentos de produtos naturais no mercado varejista, quanto em S. platensis cultivada em laboratório. Alguns pigmentos carotenóides possuem atividade de vitamina A e, dentre eles, o -caroteno é o que apresenta maior atividade biológica. A extração de -caroteno foi feita com metanol:água (90:10 v/v), seguida de saponificação e partição em n-hexano. As análises cromatográficas foram realizadas em coluna Waters Spherisorb S5 ODS 2 (4,6 x 250 mm), usando metanol:tetrahidrofurano (90:10, v/v) bombeado a 2 mL min -1 , com registro dos cromatogramas em 450 nm. Os suplementos alimentares a base de Spirulina apresentaram baixos teores de -caroteno. A maior concentração foi encontrada em S. platensis cultivada a 24° C com fotoperíodo de 16 h claro e 8 h escuro. Considerando sua atividade provitamínica, os teores de retinol equivalente (RE) nas microalgas analisadas no presente trabalho foram calculados a partir do -caroteno para classificá-las como fonte excelente ou fonte útil de vitamina A.Termos para indexação: Microalga, suplemento alimentar, CLAE. ABSTRACTSpirulina is a cyanobacterium that has been used for several centuries due to its nutritional and medicinal properties. This work has evaluated the contents of -carotene both in Spirulina commercialized as food supplement, purchased from natural product shops, and in S. platensis reared under laboratory conditions. Some carotenoids exhibit pro-vitamin A activity, and -carotene presents the greatest biological activity. -Carotene of microalgae was extracted in 90% aqueous methanol. These extracts were saponified and partitioned in n-hexane. Chromatographic analyses were carried out in a Spherisorb column S5 ODS 2 (4.6 x 250 mm), with a mobile phase of methanol:tetrahydrofuran (90:10, v/v) delivered at 2 mL min -1 and chromatograms registered at 450 nm absorbance. Food supplement made with Spirulina presented low content of -carotene. The highest content of -carotene was detected in S. platensis cultivated under 24° C with photoperiod of 16 h light and 8 h dark. Considering its pro-vitamin activity, retinol equivalent (RE) was calculated from -carotene to d...

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Antiinflammatory and Antihyperalgesic Activity of C-Phycocyanin

Cited by 111 publications

References 29 publications

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Antioxidant Effect ofSpirulina (Arthrospira) maximaon Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats

Teores de β-caroteno em suplementos e biomassa de Spirulina

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