Antiinflammatory activity of some extracts from plants used in the traditional medicine of North‐African countries (II)

Abstract

Aqueous, ethanol and chloroform extracts from Corrigiliola telephiifolia, Echinops spinosus, Kundmannia sicula, Tamarindus indica and Zygophyllum gaetulum were evaluated for antiinflammatory properties in mice (ear oedema induced by arachidonic acid) and rats (subplantar oedema induced by carrageenan) after topical or i.p. administration, respectively. Our results showed that all the plants exhibit antiinflammatory activity, since at least one extract from each plant was active in one of the experimental models. Whereas all the extracts of Corrigiliola telephiifolia and Echinops spinosus were highly active on all the experimental models assayed (values of inflammation inhibition well above 50%), poorer activity profiles were recorded in Kundmannia sicula, Tamarindus indica and Zygophyllum gaetulum. These results support the traditional uses for these plants but indicate that the active principles in the chloroform extracts are probably more active and/or are contained in larger concentrations than the principles in the polar extracts used in the traditional medicine of North-African countries.

Antipyretic, analgesic, anti-inflammatory and antioxidant activities of two major chromenes from Melicope lunu-ankenda

“…Anti-inflammatory activities of evodione and leptonol were evaluated by carrageenan-induced paw edema in rats (Winter et al, 1962;Rimbau et al, 1999;Kouadio et al, 2000). Male mice were divided into eight groups of six animals each.…”

Antinociceptive and anti-inflammatory activities ofViburnum opulus

“…The third group (reference group I) received indomethacin ( 3 mg/kg, i.p.) (Rimbau et al, 1999), and the remaining three groups received the extract at doses of 50, 100, and 200 mg/kg, i.p. The doses of extract utilized in the present study were chosen according to the LD 1 value (LD 1 = 2.345 g/kg).…”

Aqueous extract of tamarind seeds selectively increases glucose transporter-2, glucose transporter-4, and islets' intracellular calcium levels and stimulates β-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes mellitus

“…Its fruit is regarded as a digestive, carminative, laxative, expectorant, and blood tonic [8]. Other parts of the plant present antioxidant [9], antihepatotoxic [10], and antiinflammatory [11] activity. T indica was used as a traditional medicine for the management of DM [12].…”