Antiinflammatory Activity of Slime Extract from Giant African Snail (Lissachatina fulica)

Abstract

The present study aims to investigate the antiinflammatory activity of the slime extracts from the giant African snail, Lissachatina fulica. In this study, aqueous and ethanol extracts of the snail slime were evaluated for antiinflammatory activities in vitro. The aqueous extract showed greater antiinflammatory activities than the ethanol extract. The aqueous extract was further tested for antiinflammatory activity in vivo. For acute inflammation, the ear oedema assay was used to screen the slime extract. The results revealed that application of 2 mg/ear extract or phenylbutzone could significantly reduce oedema when compared with ethanol-treated ears. For chronic inflammatory test, the cotton pellet granuloma model was employed to determine the activity of the slime extract. It was found that 2.5 and 6.25 % extract could significantly reduce transudative and granuloma weights. Moreover, the extracts also reduced malondialdehyde and increased superoxide dismutase in the granuloma tissue of the induced rats. In conclusion, the slime extract showed antiinflammatory activity both in vitro and in vivo. The antiinflammatory activity was also observed against acute and chronic inflammations, which suggested that the slime extracts has the potential to be developed into antiinflammatory products.

Phytoconstituent analysis, anti-inflammatory, antimicrobial and anticancer effects of nano encapsulated Convolvulus arvensis L. extracts

“…of C. arvensis and their loaded Alg-Cs/NPs exhibited non-hemolytic activities (percent hemolysis, 3–12%) even at maximum concentration of 1000 µg/ml. The work’s outcomes concurred with those of the earlier investigation reported by Wiya et al [ 59 ]. They stated that the hemolytic effect of the both the aqueous and ethanolic slime extracts ranged from 7.01 ± 0.54 to 13.42 ± 0.28%.…”

Allantoin from Valuable Romanian Animal and Plant Sources with Promising Anti-Inflammatory Activity as a Nutricosmetic Ingredient

“…In other researches, the mucus obtained from giant African snail, Lissachatina fulica, has shown also promising anti-inflammatory potential both by in vivo tests and by in vitro tests [59]. Following the analysis performed, Sri Harti et al concluded that improving an inflammatory status with a preparation based on the combination of snail mucus and chitosan may be an alternative to synthetic compounds [60].…”

Biological activities of gastropods secretions: snail and slug slime

“…Afterward, in previous but recent researches, the extraction of snail slime still led to the killing of the animals. Wiya et al extracted the snail slime by placing the snails on a plate in warm (32 °C) water and then scrubbing the outer shell and slime was squeezed from the animal, leading to animal death [ 64 ]. Similarly, Onyema and Adikwu, both extracted the snail slime by mechanically removing the outer shell and then scrubbing the fleshy animal, leading to their death [ 65 , 66 ].…”