Antiinflammatory Activity-Guided Fractionation of Gnaphalium stramineum

Rastrelli, Luca; Saravia, Amarillis; Hernandez, Minor; Simone, Francesco De

doi:10.1076/phbi.36.5.315.4647

Cited by 14 publications

(13 citation statements)

References 12 publications

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“…Chlorogenic acids are believed to have very low toxicity because they are common constituents of plants used in human diets (Zhao and Moghadasin, 2010). Biological activities described for CGAs include antioxidant and anti-inflammatory properties (Peluso et al, 1995;Rastrelli et al, 1998). Further compounds identified from yacon leaves include diterpenes and phenylpropanoids (Qiu et al, 2008;Xie et al, 2008;Xiang et al, 2010).…”

Section: Introductionmentioning

confidence: 94%

Renal toxicity caused by oral use of medicinal plants: The yacon example

Oliveira

Paula

Rocha

et al. 2011

Journal of Ethnopharmacology

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The renal damage was associated with increased blood glucose levels after prolonged oral administration of the AE. This observation suggested that the hypoglycaemic effect observed after treatment for 30 days in an earlier study is reversible and was likely the result of renal injury caused by the toxicity of yacon. Because STLs were detected in both AE and LRE, there is strong evidence that these terpenoids are the main toxic compounds in the leaves of the yacon. Based on our results, we do not recommend the oral use of yacon leaves to treat diabetes.

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Section: Introductionmentioning

confidence: 94%

Renal toxicity caused by oral use of medicinal plants: The yacon example

Oliveira

Paula

Rocha

et al. 2011

Journal of Ethnopharmacology

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“…It was reported that among the secondary metabolites of medium and high polarity from L. ericoides, vicenin-2 (C-glucosylflavone) and the chlorogenic acids are the ones with pronounced anti-inflammatory activity, besides STLs which are not present in most plant of this species. [18][19][20]41 Correlating the collect period and biologic activities of the main metabolites in L. ericoides, the best period to collect would be when the plant was not flowering, considering the higher concentration of the metabolites with anti-inflammatory activity (chlorogenic acid and vicenin-2, reminding that the latter remains in constant concentration). Although, the desired anti-inflammatory activity may also be due to other low polarity metabolites unidentified yet in L. ericoides.…”

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confidence: 99%

Spatial and Temporal Variations in Secondary Metabolites Content of the Brazilian Arnica Leaves (Lychnophora ericoides Mart., Asteraceae)

Gobbo‐Neto¹,

Bauermeister²,

Sakamoto³

et al. 2017

J. Braz. Chem. Soc.

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The genus Lychnophora (Asteraceae) is a medicinal plant traditionally used as anti-inflammatory or analgesic agent. Its biological properties have been widely investigated and correlated with its chemical composition, which could be different between the species and even accordingly to the place and season of collection. In this work, it was investigated the spatial and temporal variations in the secondary metabolites from five populations of Lychnophora ericoides. Among them, a more diversified secondary metabolism was observed for the plants collected at Ibiraci-MG (Brazil), a city placed between two biomes, Cerrado and Atlantic Forest. The highest concentrations of chlorogenic acids were found in the Cerrado dry season (winter), while the flavonoids were higher during the rainy season (summer). Significant reduction was observed in the contents of all the secondary metabolites in old leaves, and also in flowery branches. These variations detected in L. ericoides leaves could highly influence the intensity of the biological activities of this plant.Keywords: Lychnophora ericoides, Asteraceae, traditional medicine, seasonal variation, secondary metabolites IntroductionTraditional medicine was and has been widely applied around the world for promoting health, and along the history, many drugs have been isolated from medicinal plants. [1][2][3] Due to its large size and great variety of climate and biomes, Brazil has a high biodiversity popularly used to treat different diseases. 4,5 These biological properties are attributed to the secondary metabolite contents, which are ecologically important for the plant to protect against solar radiation, and microbial and herbivore attacks. 6,7 Their accumulation in plants is described in the literature, as being influenced by changes in the environmental conditions, such as temperature, sunlight, water availability, pollution, nutrients, herbivore and microbial attacks and others. [8][9][10] As a strategy to adapt and survive under damaging conditions, plants use many complex biochemical processes to create chemical defense mechanisms, and this behavior cannot be neglected in pharmacology of medicinal plants. Thus, there are many phytochemical studies evaluating seasonal effects in the bioactive secondary metabolite production, [11][12][13] and relating their importance to the environment, 8 to understand the behavior of these plants.The genus Lychnophora (from Asteraceae family) is a plant endemic in Brazil, that has been used as a prospective source of natural products.14 This plant usually grows in the Cerrado, where are found only few arboreous and herbaceous species. 15 Some species of Lychnophora are extensively used in traditional Brazilian herbal medicine as anti-inflammatory, as well as analgesic, antimicrobial and anti-rheumatism agent. 16More specifically, L. ericoides, known as "arnica da serra" or "falsa arnica", is popularly used orally for medical purposes in the form of hydroalcoholic extracts prepared by macerating its leaves with cachaça ("aguardente"). ...

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“…Their main usage in Mexican traditional medicine is in the treatment of various respiratory diseases such as gripe, fever, asthma, throat ache, bronchitis and cough (7,2). Plants from the genus Gnaphalium are also used in some other Latin American countries to cure skin infection, as an anti-inflammatory agent, as well as anti-rheumatic [8,9]. Species from this genus that have been employed to treat breast cancer are G. arenarium L., G. conoideum K., and G. luteoalbum L. meanwhile G. obtusifolium L., G. polycephalum Michx., and G. spicatum Mill.…”

Section: Introduction mentioning

confidence: 99%

“…natalie on Cancer and Blood Cells 232 on S. aureus, S. pneumoniae and S. pyogenes [4]. G. stramineum Kunth is a Colombian medicinal plant with anti-inflammatory activity and has been suggested that its biological effects may be due to the presence of a combination of caffeoylquinic acid derivatives and flavonol glycosides [9]. The ethyl acetate fraction of the methanol extract from G. sylvaticum displayed moderate inhibitory activity (57.2%) against the HIV-1 reverse transcriptase [12].…”

Section: Introduction mentioning

confidence: 99%

The Effect of Gnaphalium oxyphyllum var. natalie on Cancer and Blood Cells

Vega-Ávila¹,

Gómez-Covarrubias²,

Espejo-Serna³

et al. 2016

JPP

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Gnaphalium oxyphyllum DC is a medicinal plant whose common uses by Mexican people include the treatment of cancer. The toxicity of the aqueous and organic fractions as well as the aqueous decoction of G. oxyphyllum var. natalie F. J. Espinosa were assessed on three human cancer cell lines as well as in blood cells in healthy human lymphocyte cultures. Cytotoxic activity was assessed by the Sulforhodamine B method on HeLa (human cervical carcinoma), T47D (human breast carcinoma) and 22Rv1 (human prostate carcinoma cancer). Colchicine was used as positive control. The decoction was also tested on lymphocytes from healthy donors through the mitotic index as biomarker. We used whole blood for these cultures and estimated the effect of the extract on platelets, leukocytes and erythrocytes. The aqueous decoction was cytotoxic (ED 50 < 20 μg/mL) on the three cancer cell lines. The mitotic index in the exposed lymphocyte cultures did not significantly differ from the control nor the blood counts showed any difference between the experimental and control cultures. These results prove that the toxic effect of the aqueous decoction of G. oxyphyllum var. natalie is specific for cancer cell lines.

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Antiinflammatory Activity-Guided Fractionation of Gnaphalium stramineum

Cited by 14 publications

References 12 publications

Renal toxicity caused by oral use of medicinal plants: The yacon example

Renal toxicity caused by oral use of medicinal plants: The yacon example

Spatial and Temporal Variations in Secondary Metabolites Content of the Brazilian Arnica Leaves (Lychnophora ericoides Mart., Asteraceae)

The Effect of Gnaphalium oxyphyllum var. natalie on Cancer and Blood Cells

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