Antiinflammation constituents from Curcuma zedoaroides

Abstract

Curcuma zedoaroides, a Zingiberaceae species, has been used for snake bite antidote and wound care in Thailand. Seven compounds were isolated from the bioactive chloroform extract consisted of one new guaiane sesquiterpene lactone, 5-epiphaeocaulisin A (4) and one new diarylheptanoid, 1,2,3,5-tetrahydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) heptane (7), together with five known guaiane-type sesquiterpene lactones including gweicurculactone (1), zedoalactone B (2), phaeocaulisin C (3), zedoalactone H (5), and zedoalactone E (6). The antiinflammation was investigated on NO and TNF-α production using RAW264.7 cells. In addition, the expressions of genes involved in inflammation including iNOS, COX-2, and TNF-α were assessed. The results found that Compounds 1-7 presented their antiinflammation against NO production. The most potential effects were demonstrated on Compounds 1 and 7 with IC of 27.3 and 32.6 μM, respectively. Although, Compounds 1 and 7 did not inhibit TNF-α production, their suppression on iNOS and COX-2 mRNA expression were revealed. These results support the ability of chloroform fraction, Compounds 1 and 7 on antiinflammation, whereas others exhibited moderate and mild effect.

Preparation and characterization of immobilized 5-HT1A receptor stationary phase for high throughput screening of the receptor-binding ligands from complex systems like Curcuma wenyujin Y. H. Chen et C. Ling extract

“…According to high-performance liquid chromatography-mass spectrometry analysis, we discovered that there were mainly three compounds in peak I. They were identified as gweicurculactone (m/z 229.1 [M+H] + ) [27] , compound 2 (m/z 679.5 [2 M+NH 4 ] + , m/z 701.5 [2 M+NH 3 +Na] + ) and curcuminol F (m/z 814.6 [2 M+H] + ) [28] with the retention time of 1.258 min, 6.269 min and 6.591 min, respectively ( Fig. 8 B-D).…”

Advances in the study of key genes and transcription factors regulating the mevalonate synthesis pathway in Edible and medicinal plants

“…It can also be divided into sesquiterpene alcohols, sesquiterpene aldehydes, sesquiterpene ketones, and sesquiterpene lactones according to the oxygen-containing functional groups. The sesquiterpenoids are also important constituents of plant volatile oils with a variety of pharmacological activities such as anti-cancer (Abu-Izneid et al, 2020), anti-oxidation (Zhang et al, 2021), anti-inflammatory (Tungcharoen et al, 2018;Lima et al, 2021), and anti-microbial (Perveen et al, 2020).…”

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

“…Guaiane sesquiterpene lactone in C. zedoaria chloroform extract decreases iNOS, cox-2, and tnf-α expression in LPS-induced RAW 264.7 cells. 50 The content of diarylheptanoid in Kaempferia galanga reduces NO production in LPS-induced RAW 264.7 cells. 51 In addition, Kaempferia galanga contains isopimarane diterpenoid compounds, which can reduce the tnf-α and cox-2 expression and NO production.…”