Antihypoxic activity of the dry extract from<i>Nepeta multifida L</i>

Razuvaeva, Ya. G.; Торопова, А. А.; Оленников, Д. Н.; Kharzheev, Dmitrij V.

doi:10.1080/14786419.2021.1935932

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Permanent focal cerebral ischemia caused by the right-sided thermocoagulation of the middle cerebral artery in rats reduces cerebral blood flow (1.25 sm/s vs. 4.10 sm/s in the sham-operated group; p < 0.05) and increases necrosis zone area to 41.52% ( Table 7 ). The application of a standardized extract of Ginkgo biloba (EGB761) demonstrated a positive effect characterized by increased cerebral blood flow (2.63 sm/s; p < 0.05) and reduction of necrosis zone area down to 21.60% ( p < 0.05), which is typical for the plant extracts with neuroprotective effects such as Ginkgo biloba [ 105 ], Rhaponticum uniflorum [ 106 ], Serratula centauroides [ 107 ], and Nepeta multifida [ 108 ]. The nanosuspension of HSO in doses of 0.1–1 mL/kg demonstrated a positive dose-dependent effect, which increased with dose.…”

Section: Resultsmentioning

confidence: 99%

Hogweed Seed Oil: Physico–Chemical Characterization, LC-MS Profile, and Neuroprotective Activity of Heracleum dissectum Nanosuspension

Оленников

Чирикова

2023

Life

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The seeds of dissected hogweed (Heracleum dissectum Ledeb., Apiaceae) are the source of hogweed oil (HSO), which is still underexplored and requires careful chemical and biological studies. The performed physico–chemical analysis of HSO elucidated basic physical characteristics and revealed the presence of fatty acids, essential oil components, pigments, and coumarins. High-performance liquid chromatography with photodiode array detection and electrospray ionization triple quadrupole mass spectrometric detection (HPLC–PDA–ESI–tQ–MS/MS) identified 38 coumarins that were characterized and quantified. Various furanocoumarins were the major components of HSO polyphenolics, including imperatorin, phellopterin, and isoimperatorin, and the total coumarin content in HSO varied from 181.14 to 238.42 mg/mL. The analysis of storage stability of the selected compounds in HSO indicated their good preservation after 3-year storage at cold and freezing temperatures. The application of the CO2-assisted effervescence method allowed the production of an HSO nanosuspension, which was used in a brain ischemia model of rats. The HSO nanosuspension enhanced cerebral hemodynamics and decreased the frequency of necrotic processes in the brain tissue. Thus, H. dissectum seeds are a good source of coumarins, and HSO nanosuspension promotes neuroprotection of the brain after lesions, which supports earlier ethnopharmacological data.

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Section: Resultsmentioning

confidence: 99%

Hogweed Seed Oil: Physico–Chemical Characterization, LC-MS Profile, and Neuroprotective Activity of Heracleum dissectum Nanosuspension

Оленников

Чирикова

2023

Life

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“…The predicted antihypoxic effect can be used to reduce oxidative stress in the prevention and treatment of chronic diseases [ 54 , 55 , 56 , 57 ]. In contrast, JAK2 expression inhibition could be used in the treatment of inter alia, diabetic kidney disease [ 58 ], polycythemia vera, essential thrombocythemia, idiopathic myelofibrosis [ 59 ], and cancer [ 60 , 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

Glycosylation of Methylflavonoids in the Cultures of Entomopathogenic Filamentous Fungi as a Tool for Obtaining New Biologically Active Compounds

Krawczyk-Łebek

Dymarska

Janeczko

et al. 2022

IJMS

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Flavonoid compounds are secondary plant metabolites with numerous biological activities; they naturally occur mainly in the form of glycosides. The glucosyl moiety attached to the flavonoid core makes them more stable and water-soluble. The methyl derivatives of flavonoids also show increased stability and intestinal absorption. Our study showed that such flavonoids can be obtained by combined chemical and biotechnological methods with entomopathogenic filamentous fungi as glycosylation biocatalysts. In the current paper, two flavonoids, i.e., 2′-hydroxy-4-methylchalcone and 4′-methylflavone, have been synthesized and biotransformed in the cultures of two strains of entomopathogenic filamentous fungi Isaria fumosorosea KCH J2 and Beauveria bassiana KCH J1.5. Biotransformation of 2′-hydroxy-4-methylchalcone resulted in the formation of two dihydrochalcone glucopyranoside derivatives in the culture of I. fumosorosea KCH J2 and chalcone glucopyranoside derivative in the case of B. bassiana KCH J1.5. 4′-Methylflavone was transformed in the culture of I. fumosorosea KCH J2 into four products, i.e., 4′-hydroxymethylflavone, flavone 4′-methylene-O-β-d-(4″-O-methyl)-glucopyranoside, flavone 4′-carboxylic acid, and 4′-methylflavone 3-O-β-d-(4″-O-methyl)-glucopyranoside. 4′-Methylflavone was not efficiently biotransformed in the culture of B. bassiana KCH J1.5. The computer-aided simulations based on the chemical structures of the obtained compounds showed their improved physicochemical properties and antimicrobial, anticarcinogenic, hepatoprotective, and cardioprotective potential.

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Flavonoids and Lignans of Nepeta multifida (Lamiaceae) Leaves and Their Biological Activity

Kashchenko,

Olennikov

2023

Russ J Bioorg Chem

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Antihypoxic activity of the dry extract fromNepeta multifida L

Cited by 4 publications

References 15 publications

Hogweed Seed Oil: Physico–Chemical Characterization, LC-MS Profile, and Neuroprotective Activity of Heracleum dissectum Nanosuspension

Hogweed Seed Oil: Physico–Chemical Characterization, LC-MS Profile, and Neuroprotective Activity of Heracleum dissectum Nanosuspension

Glycosylation of Methylflavonoids in the Cultures of Entomopathogenic Filamentous Fungi as a Tool for Obtaining New Biologically Active Compounds

Flavonoids and Lignans of Nepeta multifida (Lamiaceae) Leaves and Their Biological Activity

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