Antihypertensive Pharmacotherapy: Adverse Effects of Medications Promote Nonadherence

Fergus, Icilma

doi:10.1111/j.1559-4572.2008.00053.x

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…Было показано, что отказ от вредных привычек у пациентов с ЭД и АГ значительно повышает приверженность терапии и готовность больных придерживаться постоянного лечения [61]. Действительно, как сообщают многие пациенты, возникновение проблем с потенцией на фоне приема гипотензивных препаратов и является причиной низкой приверженности терапии [62]. С другой стороны, прием препаратов из группы ИФДЭ-5, по-видимому, способствует приверженности гипотензивной терапии, повышению уровня контроля АД и, таким образом, дает возможность снизить ССР у пациентов с АГ и ЭД [63].…”

Section: модификация образа жизниunclassified

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

et al. 2021

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Sexual health is an essential part of overall health, and an active and healthy sex life is an important aspect of a good quality of life. Cardiovascular diseases and sexual health disorders have common risk factors (arterial hypertension, diabetes mellitus, dyslipidemia, obesity and smoking) and common pathogenesis (endothelial dysfunction, inflammation and atherosclerosis). All this led to speculations about the pathophysiology and treatment options for sexual dysfunctions. The use of phosphodiesterase type 5 inhibitors has revolutionized the treatment of erectile dysfunction (ED) in men. This article focuses on ED and its relationship with hypertension. This document was created by experts from the Russian Medical Society of Arterial Hypertension with the participation of a member of the European Society of Hypertension Working Group on Sexual Dysfunction and Arterial Hypertension. In recent years, the expert group was very active in educating hypertension specialists and related specialties physicians about ED via numerous lectures at national and international congresses. It has been noted that ED precedes the development of coronary heart disease. The artery diameter hypothesis has been proposed as a possible explanation for this observation. Clinical manifestations of atherosclerotic lesions and/or endothelial dysfunction of the penile arteries may precede those in larger arteries. Patients with hypertension who receive antihypertensive drugs are more likely to suffer from sexual dysfunctions compared to untreated patients. The occurrence of ED appears to be related to the undesirable effects of antihypertensive drugs on the penile tissues. There is information about various effects of antihypertensive drugs on erectile function.

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Section: модификация образа жизниunclassified

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

et al. 2021

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“…Adherence to CVD medications can involve a complex interplay of patient and treatment characteristics (Munger et al, 2007). Factors that have been suggested to influence non-adherence to CVD medication include being of a younger age (Hassan et al, 2005), suffering from depression (Aggarwal and Mosca, 2010), complexity of the prescription regimen (Grégoire et al, 2006), beliefs about necessity (Ruppar et al, 2012), beliefs about medication (Benson and Britten, 2002;Ogedegbe et al, 2004;Fergus, 2009) and beliefs about the severity of CVD (Stafford et al, 2008).…”

Section: Adherencementioning

confidence: 99%

Cardiovascular disease: the effect of erectile dysfunction on adherence to cardiovascular disease medication

Williams

McBain

Mulligan

et al. 2014

Int J of Uro Nursing

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Due to their similar aetiologies, cardiovascular disease (CVD) and erectile dysfunction (ED) are closely linked, with the prevalence of ED being approximately 75% for individuals at high risk of CVD. ED can have a detrimental effect on quality of life not only for the individual but also his sexual partner which in turn impacts upon their intimate relationship. Some CVD medications have been found to have a negative effect on erectile function and therefore act as an influential factor for the cessation of important CVD medication. Low adherence to CVD medication has been linked to increased health costs, hospitalizations and importantly, a higher risk of mortality. Research has shown that men find it difficult to seek medical help in relation to ED which is also compounded by the notion that health care providers do not address sexual issues adequately. Patients' beliefs about CVD medication are modifiable and therefore an opportunity exists not only for health care providers to facilitate discussions in relation to ED and medication adherence but also encompass an opportunity to increase adherence to CVD medication through intervention.

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“…Medication‐associated ED is commonly cited by patients as a reason for medication nonadherence [15,38]. Focus groups of men with hypertension (N = 38) and their spouses (N = 13) revealed that commonly discussed strategies to manage ED effects of antihypertensives were to discontinue antihypertensive therapy or to practice selective nonadherence in anticipation of a sexual encounter [39].…”

Section: Impact Of Medication‐associated Ed On Adherencementioning

confidence: 99%

Erectile Dysfunction Diagnosis and Treatment as a Means to Improve Medication Adherence and Optimize Comorbidity Management

Scranton¹,

Goldstein

Stecher

2013

The Journal of Sexual Medicine

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Introduction Optimal pharmacologic management of diseases comorbid with erectile dysfunction (ED), such as cardiovascular disease, depression, diabetes, dyslipidemia, hypertension, and benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), is dependent upon long-term treatment compliance and may be complicated by poor adherence to medication use. ED may contribute to poor adherence to medication use because poor quality erectile function may be an unwanted adverse effect of antihypertensives, antidepressants, and 5-α reductase inhibitors for treatment of BPH/LUTS. Diminished erectile spontaneity, rigidity, and/or sustaining capability also negatively affects mood, self-esteem, and confidence, which compromise motivation to be compliant with medications that treat diseases comorbid with ED. Aim Literature review was performed to explore the role of ED diagnosis and effective treatment in enhancing overall management of selected ED comorbidities, highlighting the role of medication adherence. Methods Several PubMed searches were performed. Results Diagnosis and successful treatment of concomitant ED may promote improved adherence and management of comorbid diseases. Concomitant ED management may improve treatment outcome, decrease healthcare costs, and possibly prevent or even improve deterioration in medical conditions comorbid with ED. Because ED is a silent marker and predictor of comorbidities, especially cardiovascular disease, earlier diagnosis of ED may provide an opportunity to prevent future cardiovascular events. In men presenting with complaints of ED, screening for, monitoring, and appropriately treating diseases that are comorbid with ED is essential. Screening for and appropriately treating ED is important for enhanced life quality and improved motivation in men with existing ED comorbidities or risk factors. Conclusions Appropriate management of ED and its risk factors may have beneficial effects on diseases that are comorbid with ED, and vice versa, most likely via shared pathophysiological pathways. Clinicians may need to consider men's health overall, of which sexual health is a central component, in order to provide optimal disease management.

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Antihypertensive Pharmacotherapy: Adverse Effects of Medications Promote Nonadherence

Cited by 7 publications

References 23 publications

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

Cardiovascular disease: the effect of erectile dysfunction on adherence to cardiovascular disease medication

Erectile Dysfunction Diagnosis and Treatment as a Means to Improve Medication Adherence and Optimize Comorbidity Management

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