Antihypertensive Peptides from Marine Sources

Norris, Roseanne; Harnedy, Pádraigín A.; Fitzgerald, Richard J.

doi:10.1002/9781118412893.ch2

Cited by 11 publications

(8 citation statements)

References 148 publications

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“…primary structure of these peptides. Furthermore, identified peptides fulfilled some structural features of C-terminal region reported for ACE-inhibitory peptides, 51 which suggest their potential as contributors of the biological activity of lentil hydrolasates. These include the presence of proline, bulky hydrophobic residues, and aromatic or branched chains, at position 1 or more positions, positively charged amino acids (Arg, Lys) at position 2, and aromatic amino acids (Tyr, Phe, Trp) at position 3.…”

Section: ■ Results and Discussionmentioning

confidence: 65%

High-Pressure-Assisted Enzymatic Release of Peptides and Phenolics Increases Angiotensin Converting Enzyme I Inhibitory and Antioxidant Activities of Pinto Bean Hydrolysates

García-Mora

Peñas

Frı́as

et al. 2016

J. Agric. Food Chem.

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Pinto bean protein concentrate was hydrolyzed by subtilisins at 0.1, 100, and 200 MPa and 50 °C for 15 min. Alcalase hydrolysis at 100 MPa led to higher ACE inhibition, reducing power, and free radical scavenging activity of hydrolysates. However, hydrolysate obtained by Savinase at 200 MPa showed the best ACE-inhibitory and radical scavenging activities. Proteolysis by Savinase at 200 MPa was considered the most effective treatment to increase small peptides (<3 kDa), flavonoids, total phenolic compounds, and oxygen radical absorbance capacity in hydrolysates. In this hydrolysate, small phaseolin fragments with reported ACE-inhibitory and antioxidant sequences were identified. Catechin, pelargonidin 3-glucoside, and ferulic acid were the main phenolic compounds. Hihg-pressure-assisted hydrolysis of common bean protein concentrates would provide benefits in the production of functional hydrolysates providing higher functionality and added value to the resulting hydrolysate due to synergistic effects of bioactive peptides and soluble phenolics.

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Section: ■ Results and Discussionmentioning

confidence: 65%

High-Pressure-Assisted Enzymatic Release of Peptides and Phenolics Increases Angiotensin Converting Enzyme I Inhibitory and Antioxidant Activities of Pinto Bean Hydrolysates

García-Mora

Peñas

Frı́as

et al. 2016

J. Agric. Food Chem.

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show abstract

“…They have biological properties such as antioxidant, antithrombotic, antihypertensive, immunomodulation, anticancer, and antibacterial actions, among others (Hamed et al, 2015). Peptides produced from marine protein sources could be beneficial as vital antihypertensive compounds which can be incorporated incorporation into functional foods (Norris et al, 2013;Cunha and Pintado, 2021).…”

Section: Peptidesmentioning

confidence: 99%

Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development

Ghosh

Sarkar

Pati³

et al. 2022

Front. Mar. Sci.

111

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The marine environment is a relatively unexplored source of functional ingredients that can be used in food processing, storage, and fortification in a variety of ways. Marine microorganisms are a possible source of novel bioactive chemicals with potential human utility. Some of these microbes can live in the harsh marine environments, resulting in complex compounds with unique biological properties that can be used in several industrial and biotechnological applications. So far, several marine microorganisms (fungi, myxomycetes, bacteria, and microalgae) have been isolated that produce antioxidant, antibacterial, apoptotic, antitumoral, and antiviral chemicals. Furthermore, it emphasizes the enormous potential for marine microbes to produce very important bioactive chemicals. The main goal of this review is to provide a concise overview of several constituents of marine bioactives. Anticoagulant, anticancer, and hypocholesterolemic effects have been demonstrated for bioactive peptides extracted from fish protein hydrolysates, as well as algal fucans, galactans, and alginates. Furthermore, omega-3 fatty acids are abundant in fish oils and marine microorganisms, while potent antioxidants such as carotenoids and phenolic compounds can be found in crustaceans and seaweeds. This review focuses on the potential use of marine-derived chemicals as functional food ingredients for health maintenance and chronic disease prevention, based on their bioactive qualities.

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“…Hypertension accounts for an estimated 54% of all strokes and 47% of all ischaemic heart disease events globally (Lawes et al ., ). Peptides with antihypertensive activity have been reported (Norris et al ., ). Microalgae remain a relatively untapped reserve of antihypertensive peptides.…”

Section: Bcmms With Hypotensive Hypoglycaemic and Hypolipidaemic Actmentioning

confidence: 99%

Hypotensive, hypoglycaemic and hypolipidaemic effects of bioactive compounds from microalgae and marine micro‐organisms

Zhao

Yang

et al. 2015

Int J of Food Sci Tech

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Microalgae and marine micro-organisms (MMs) have received increasing attention for the production of biologically active compounds due to their exclusive characteristics, which have adapted to the specific and extreme conditions of environments. These micro-organisms are of considerable importance as new and promising potential sources of a huge number of natural bioactive compounds for functional foods and pharmaceutical development. Important natural bioactive compounds exhibiting a wide range of activities such as antimicrobial, antitumour, antioxidative, anti-inflammatory, antiviral, antituberculosis, antiparasitic, anthelmintic, antimalarial, antiprotozoal, anticoagulant and antiplatelet effects have recently been isolated. To date, only a small number of MMs have been investigated for hypotensive, hypoglycaemic and hypolipidaemic activities. This study focuses specifically on revealing and discussing prospective human applications of MMs on functional foods and clinical practice and their metabolites associated with hypotensive, hypoglycaemic and hypolipidaemic activities.

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Antihypertensive Peptides from Marine Sources

Cited by 11 publications

References 148 publications

High-Pressure-Assisted Enzymatic Release of Peptides and Phenolics Increases Angiotensin Converting Enzyme I Inhibitory and Antioxidant Activities of Pinto Bean Hydrolysates

High-Pressure-Assisted Enzymatic Release of Peptides and Phenolics Increases Angiotensin Converting Enzyme I Inhibitory and Antioxidant Activities of Pinto Bean Hydrolysates

Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development

Hypotensive, hypoglycaemic and hypolipidaemic effects of bioactive compounds from microalgae and marine micro‐organisms

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