Antihypertensive Medication Use Among Recruits for the Trial of Nonpharmacologic Interventions in the Elderly (TONE)

Espeland, Mark A.; Kumanyika, Shiriki; Kostis, John B.; Algire, Jenifer; Applegate, William B.; Ettinger, Walter H.; Bahnson, Judy

doi:10.1111/j.1532-5415.1996.tb01367.x

Cited by 15 publications

(6 citation statements)

References 37 publications

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“…In contrast, however, thiazides were prescribed almost twice as often in women compared with men. This finding has been previously reported [17, 25], but without clear explanation. Guidelines for choosing antihypertensive medication in the elderly do not differ between men and women [26].…”

Section: Discussionsupporting

confidence: 70%

Prescription patterns of diuretics in Dutch community‐dwelling elderly patients

Kraaij

Jansen

Gier

et al. 1998

Brit J Clinical Pharma

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Aims To describe age-and gender-related prescription patterns of diuretics in community-dwelling elderly, and to compare diuretics to other cardiovascular (CV) medications. Methods Cross-sectional study of patient-specific prescription data derived from a panel of 10 Dutch community pharmacies. Determination of proportional prescription rates and prescribed daily dose (PDD) of diuretics, cardiac glycosides, nitrates, angiotensin converting enzyme (ACE) inhibitors, b-adrenoceptor blockers, and calcium channel blockers in all 5326 patients aged 65 years or older dispensed CV medications between August 1st, 1995 and February 1st, 1996. Results Diuretics were prescribed to 2677 of 5326 patients (50.3%), 1325 patients (24.9%) using thiazides and 1198 patients (22.5%) using loop diuretics. Prescription rates of loop diuretics increased from 15.1% in patients aged 65-74 years to 37.2% in patients aged 85 years or older. Rates also increased for digoxin and nitrates. Rates for thiazide diuretics remained unchanged with age; rates for b-adrenoceptor blockers, ACE inhibitors and calcium channel blockers declined with age. Thiazides were prescribed to 30.1% of women compared with 16% of men ( P<0.001). Average PDD was 135±117% of defined daily dose (DDD) for loop diuretics, and highest for bumetanide (245±2.01% of DDD, equivalent to 2.5±2.0 mg). Average PDD was 74±40% of DDD for thiazides, and highest for chlorthalidone (100±49% of DDD, equivalent to 25±12 mg). Conclusions Important characteristics of diuretic usage patterns in this elderly population were a steep increase in loop diuretic use in the oldest old, a large gender difference for thiazide use, and high prescribed doses for thiazides.

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Section: Discussionsupporting

confidence: 70%

Prescription patterns of diuretics in Dutch community‐dwelling elderly patients

Kraaij

Jansen

Gier

et al. 1998

Brit J Clinical Pharma

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“…In addition, no differences in the self-reported overall health status of men and women in the weight loss and nonweight-loss interventions at baseline were found (data not shown). Before enrollment in TONE, the women had been treated with hypertension medication longer than had the men, and the treatment regimens differed between the women and men (21). During TONE, there was no evidence that withdrawal of antihypertensive therapy put women at greater risk than men for cardiovascular events (22).…”

Section: Discussionmentioning

confidence: 98%

The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial

Shea¹,

Nicklas²,

Houston³

et al. 2011

The American Journal of Clinical Nutrition

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“…The fact that these findings are consistent with other studies points to a rapid increase in the prescription of ACE inhibitors and calcium-antagonists, and a corresponding decrease in the prescription of diuretics. [35][36][37] Old age, as well as comorbidity frequently present in elderly patients, have probably contributed to cause this change in prescription attitudes. 38,39 …”

Section: Discussionmentioning

confidence: 99%

Prevalence, awareness, treatment and control of hypertension in the elderly: results from a population survey

et al. 2000

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Prevalence, awareness, treatment and control of hypertension were assessed in 1032 (90%) of 1147 elderly (у65 years) inhabitants of three Italian villages. Blood pressure (BP) was measured at home on two separate occasions following a standardised protocol. Persons taking antihypertensive drugs or with BP values у140/90 mm Hg were considered as affected by hypertension. Prevalence of hypertension was 64.8%, with higher rates in women than men, and in those aged 75-84 than in those aged 65-74. Diabetes, strokes and hypercholesterolaemia were more frequent in hypertensive than normotensive people, whereas cardiac diseases, overweight and smoking did not differ significantly between hypertensive and normotensive people. Of the 669 hypertensive patients, 439 (65.6%) were aware of their hypertension, 398 (59.5%) were being treated, and 70 (10.5%) had their hypertension con-

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Antihypertensive Medication Use Among Recruits for the Trial of Nonpharmacologic Interventions in the Elderly (TONE)

Cited by 15 publications

References 37 publications

Prescription patterns of diuretics in Dutch community‐dwelling elderly patients

Prescription patterns of diuretics in Dutch community‐dwelling elderly patients

The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial

Prevalence, awareness, treatment and control of hypertension in the elderly: results from a population survey

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