Antihypertensive Efficacy, Safety, and Tolerability of Isradipine in Hypertensive Patients With Diabetes

This study evaluates the effects of lercanidipine antihypertensive treatment on glucose homeostasis in patients with type II diabetes mellitus with mild to moderate hypertension. Forty patients were enrolled. After a 2-week wash-out period, they were randomly allocated to receive in double-blind manner either 10 mg or 20 mg in single daily administration for 8 weeks. Nonresponding patients after the initial 4 weeks, were titrated up to 20 mg and 30 mg lercanidipine, respectively. At the end of the double-blind treatment, all patients entered in single-blind 4 weeks placebo follow-up. Systolic and diastolic blood pressure significantly decreased in both groups of patients after 4 weeks of treatment, and decreased further during the following 4 weeks. In both groups, progressive and significant decrease in fasting blood glucose, glycosylated hemoglobin and area under the curve of the oral glucose tolerance test were detected during lercanidipine treatment. Similarly, a decrease in serum fructosamine values were also observed. All variables returned to towards baseline values during the placebo follow-up period. Adverse events (headache and mild asthenia) were limited to two patients and resolved spontaneously. These data indicate that lercanidipine is effective in lowering high blood pressure in hypertensive patients with type II diabetes mellitus and does not exert negative effects on glucose homeostasis.

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Antihypertensive Efficacy, Safety, and Tolerability of Isradipine in Hypertensive Patients With Diabetes

Cited by 4 publications

References 0 publications

Isradipine SRO in patients with hypertension and diabetes: a multicenter study

Isradipine SRO in patients with hypertension and diabetes: a multicenter study

Antihypertensive therapy with the calcium channel blocker isradipine: An appropriate choice for the diabetic patient with hypertension

Lercanidipine in Type II Diabetic Patients With Mild to Moderate Arterial Hypertension

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