Antihypertensive Efficacy and Tolerability of a Fixed Combination of Metoprolol and Felodipine in Comparison with the Individual Substances in Monotherapy

Dahlöf, Björn; Hosie, J

doi:10.1097/00005344-199012000-00008

Cited by 19 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 The fixed dose combination of beta blocker and calcium channel blocker provides efficiency and tolerability in the treatment of arterial hypertension. 23 Overall, 24.10% patients in our study received fixed dose combinations. This may be an attempt to improve patient compliance and reduce treatment costs.…”

Section: Discussionmentioning

confidence: 75%

Prescription Pattern In Hypertensive Patients In A Tertiary Care Teaching Hospital, Dhaka, Bangladesh

Roy

Khandaker

Uddin³

et al. 2018

J Shaheed Suhrawardy Med Coll

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 75%

Prescription Pattern In Hypertensive Patients In A Tertiary Care Teaching Hospital, Dhaka, Bangladesh

Roy

Khandaker

Uddin³

et al. 2018

J Shaheed Suhrawardy Med Coll

View full text Add to dashboard Cite

show abstract

“…Concomitant treatment with felodipine 10mg twice daily and metoprolol 100mg twice daily for 5 days caused a significant increase in mean AVC of metoprolol from 5 to 6.6 mol· h/L (Smith et al 1987), but metoprolo1 did not alter the plasma concentrations of felodipine. A possible increase in the plasma concentration of metoprolol during concomitant treatment has been suggested (Dahlof & Hosie 1990). In contrast, others reported a slight but significant reduction in plasma metoprolol concentrations in patients with hypertension during treatment with felodipine (Bengtsson- Hasselgren et al 1989).…”

Section: Other Drugsmentioning

confidence: 99%

Felodipine Clinical Pharmacokinetics

Dunselman

Edgar

1991

Clinical Pharmacokinetics

View full text Add to dashboard Cite

Absorption of felodipine is rapid and complete. A pronounced first-pass metabolism results in a bioavailability of 15%, irrespective of the oral formulation used. The peak plasma concentrations and area under the plasma concentration-time curve are linearly related to the dose. The variability in plasma concentrations is wide, and individualization of the dosage is recommended. Plasma felodipine concentrations are increased in the elderly, and in patients with congestive heart failure or liver cirrhosis; in these patients felodipine should be started at a low dosage. Food intake has no clinically significant effect on felodipine absorption. Serum digoxin concentrations are increased by felodipine in plain tablet form, but not when it is administered as extended release tablets. Activators, inducers and inhibitors of the cytochrome P450 system affect the plasma concentrations of felodipine. No displacement reactions with high affinity protein binding drugs have been observed. There is a significant correlation between plasma concentration and haemodynamic effect. The mean elimination half-life of 24h together with the extended release formulation of felodipine favours once-daily dosage in patients with hypertension.

show abstract

“…23,24 In non-placebo-controlled studies, the rates of edema with dihydropyridine CCBs ranged from 5% to 28% with nifedipine, [25][26][27][28][29] 2% to 32% with amlodipine, 29 -34 0% to 30% with felodipine, 24,26,30,[35][36][37][38][39] 8% to 14% with isradipine, 37,40 8% to 15% with nicardipine, 41 19% with nisoldipine, 42 6% with lacdipine, 43 and 5% to 17% with nitrendipine. 44,45 Two non-placebocontrolled studies, one using nifedipine and the other isradipine, did not report edema as an adverse event.…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

“…73,84 In placebo controlled studies of atenolol, metoprolol CR, and pindolol, the edema rates for the ␤-blockers varied from 1.7% to 6% compared with 1.9% to 20% in the placebo groups. 23,24,59,111 A number of non-placebo-controlled studies of ␤-blockers have reported variable rates of edema: 1% to 6% for atenolol 25,43,60,72 ; 0% to 5% for metoprolol 35,36,59,112,113 ; 0% for carvedilol 45 ; 0% for pindolol 45 ; and 1% for dilevalol. 112 Two trials that lacked a placebo group documented lower extremity edema frequently in subjects treated with ␤-blockers.…”

Section: ␤-Blockersmentioning

confidence: 99%

Fluid Matters in Choosing Antihypertensive Therapy: A Hypothesis That the Data Speak Volumes

Blankfield

2005

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

Assuming that blood pressure is lowered equivalently, diuretics are more effective than angiotensinconverting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), and ␣-adrenergic receptor blockers (␣-blockers) at preventing heart failure, and they are more effective than ACEIs and ␣-blockers at preventing strokes. Compared with ␤-adrenergic receptor blockers (␤-blockers) and ACEIs, CCBs are less effective at reducing myocardial infarcts and heart failure. There is currently no conceptual framework by which to organize data indicating that some antihypertensive medications are better than others at preventing cardiovascular diseases. The thesis of this article is that the fluid reduction or fluid retention attributable to antihypertensive medications, either alone or in combination, provides a basis for ranking these medications. Diuretics have a theoretical advantage compared with other antihypertensive medications because they reduce total body fluid more than other agents. Therefore, they are the preferred drugs for treating hypertension. Provided that blood pressure is lowered comparably, diuretics have been demonstrated to be more effective than angiotensin-converting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), and ␣-adrenergic receptor blockers (␣-blockers) at preventing heart failure, and diuretics have been found to be more effective than ACEIs and ␣-blockers at preventing stokes.

show abstract

Antihypertensive Efficacy and Tolerability of a Fixed Combination of Metoprolol and Felodipine in Comparison with the Individual Substances in Monotherapy

Cited by 19 publications

References 0 publications

Prescription Pattern In Hypertensive Patients In A Tertiary Care Teaching Hospital, Dhaka, Bangladesh

Prescription Pattern In Hypertensive Patients In A Tertiary Care Teaching Hospital, Dhaka, Bangladesh

Felodipine Clinical Pharmacokinetics

Fluid Matters in Choosing Antihypertensive Therapy: A Hypothesis That the Data Speak Volumes

Contact Info

Product

Resources

About