Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: Evidence for the inhibition of angiotensin converting enzyme

Gasparotto, Arquimedes; Lourenço, Emerson Luiz Botelho; Crestani, Sandra; Stefanello, Maria Élida Alves; Salvador, Marcos José; Silva-Santos, José Eduardo da; Marques, Maria Consuelo Andrade; Kassuya, Cândida Aparecida Leite

doi:10.1016/j.jep.2010.12.026

Cited by 134 publications

(61 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies have evaluated their antihypertensive effects under in vitro conditions. The mechanisms of actions of flavonoids include functioning as ACE inhibitors 18 , antioxidant activity and vasorelaxation 19 . In the current study, 0.5 g of APE kgG 1 of body weight, was incorporated as the daily dose which contained 25 mg of total polyphenols where the majority (around 20 mg) were flavonoids.…”

Section: Discussionmentioning

confidence: 99%

“…There are different plant extracts examined on the hypotensive effects. Traditional herbal extracts 18 , blueberry 22 , cocoa 20 , purple corn, purple sweet potato and red radish 19 are some examples. A Brazilian folk medicine Cecropia glaziovii Sneth has reduced the mean systolic blood pressure by 20 mm Hg after 2 weeks of treatments where the single dose treatments of the extracts had not exerted any difference 20 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antihypertensive Effects of Apple Peel Extract on Spontaneously Hypertensive Rats

Balasuriya¹,

Rupasinghe²,

Sweeney³

et al. 2015

Pharmacologia

View full text Add to dashboard Cite

Background and Objectives:Apple peel is a rich source of biological active phytochemicals such as flavonoids. The present study investigated the antihypertensive effect of flavonoid-rich Apple Peel Extract (APE) on Spontaneously Hypertensive Rats (SHR). Methodology: Three groups of animals: Control, captopril (20 mg kgG 1 of body weight/day) and APE (25 mg kgG 1 of body weight/day) were fed standard rat chow and their corresponding treatment in sugar-free gelatin, daily for a period of eight weeks. Blood Pressure (BP) was monitored weekly using the tail cuff method. Blood and tissue samples were collected after the eighth week. Results: As expected, treatment with captopril consistently reduced BP (p<0.05). APE treatment reduced both systolic and diastolic BP by 15 and 11 mg Hg, respectively, after 5 weeks of treatment, However, statistical significance was only achieved in systolic BP after eight weeks when compared with control (p<0.05). There were no significant differences in serum and lung ACE activity at week eight. Treatment with APE increased liver superoxide dismutase (SOD) activity by 78% and total reduced Glutathione (GSH) concentrations by 42% when compared to control (p<0.05) but had no effect on the activity of glutathione reductase or peroxidase. Conclusion: Long term intake of APE reduces high blood pressure in SHR possibly through endogenous antioxidant pathways. This preclinical trial suggests that APE as a dietary supplement could be effective in managing early stages of hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antihypertensive Effects of Apple Peel Extract on Spontaneously Hypertensive Rats

Balasuriya¹,

Rupasinghe²,

Sweeney³

et al. 2015

Pharmacologia

View full text Add to dashboard Cite

show abstract

“…Isoquercitrin, also known as quercetin-3-glucoside, is a glucose-bound derivative of quercetin that is commonly found in medicinal herbs, fruits, vegetables, and plant-derived foods and beverages [10][11][12][13][14]. In recent studies, isoquercitrin has been reported to possess anti-Mayaro virus, anti-inflammatory, anti-oxidative, anti-allergic, anti-hypertensive, anti-hyperglycemic, and saluretic/diuretic effects [15][16][17][18][19][20][21][22][23]. Although the antioxidative and neuroprotective effects of isoquercitrin have been established, whether isoquercitrin could exert an anti-apoptotic effect on endothelial cells is not clear.…”

Section: Molecules2016 21 360mentioning

confidence: 99%

“…In recent studies, isoquercitrin has been reported to possess anti-Mayaro virus, anti-inflammatory, anti-oxidative, anti-allergic, anti-hypertensive, anti-hyperglycemic, and saluretic/diuretic effects [15][16][17][18][19][20][21][22][23]. Although the antioxidative and neuroprotective effects of isoquercitrin have been established, whether isoquercitrin could exert an anti-apoptotic effect on endothelial cells is not clear.…”

Section: Introductionmentioning

confidence: 99%

Isoquercitrin Inhibits Hydrogen Peroxide-Induced Apoptosis of EA.hy926 Cells via the PI3K/Akt/GSK3β Signaling Pathway

Zhu

Wang

et al. 2016

Molecules

View full text Add to dashboard Cite

Abstract:Oxidative stress plays a critical role in endothelial injury and the pathogenesis of diverse cardiovascular diseases, including atherosclerosis. Isoquercitrin (quercetin-3-glucoside), a flavonoid distributed widely in plants, exhibits many biological activities, including anti-allergic, anti-viral, anti-inflammatory, and anti-oxidative effects. In the present study, the inhibitory effect of isoquercitrin on H 2 O 2 -induced apoptosis of EA.hy926 cells was evaluated. MTT assays showed that isoquercitrin significantly inhibited H 2 O 2 -induced loss of viability in EA.hy926 cells. Hoechst33342/PI and Annexin V-FITC/PI fluorescent double staining indicated that isoquercitrin inhibited H 2 O 2 -induced apoptosis of EA.hy926 cells. Western blotting demonstrated that isoquercitrin prevented H 2 O 2 -induced increases in cleaved caspase-9 and cleaved caspase-3 expression, while increasing expression of anti-apoptotic protein Mcl-1. Additionally, isoquercitrin significantly increased the expression of p-Akt and p-GSK3β in a dose-dependent manner in EA.hy926 cells. LY294002, a PI3K/Akt inhibitor, inhibited isoquercitrin-induced GSK3β phosphorylation and increase of Mcl-1 expression, which indicated that regulation of isoquercitrin on Mcl-1 expression was likely related to the modulation of Akt activation. These results demonstrated that the anti-apoptotic effect of isoquercitrin on H 2 O 2 -induced EA.hy926 cells was likely associated with the regulation of isoquercitrin on Akt/GSK3β signaling pathway and that isoquercitrin could be used clinically to interfere with the progression of endothelial injury-associated cardiovascular disease.

show abstract

“…폴리페놀의 일 종인 quercetin (QU)은 양파의 껍질 [2], 구절초 [3], 사과 과피 [4], 참가 시나무 [5] 등에 존재하는 것으로 알려져 있다. QU의 배당체인 isoquercitrin (IQ)은 항산화 [6], 항염증 [7], 항고혈압성 [8] 작용과 항알 러지 [9], 항암작용 [10] 등 다양한 약리효과가 있으나, 그의 연구가 제 한적이었다. 그 이유는 천연에서의 IQ의 존재량이 매우 적을 뿐만 아 니라 다양한 불순물의 존재 때문에 추출하는 것이 매우 어렵기 때문 이다 [11].…”

Section: )unclassified

Study on the Synthesis of Isoquercitrin by Enzymatic Partial Hydrolysis

Lee¹,

Chung

2014

Applied Chemistry for Engineering

View full text Add to dashboard Cite

Isoquercitrin (IQ), quercetin monoglycoside, is classified as a polyphenol, and a minute quantity of IQ is known to be present in several plants. Recently, it was reported that IQ can be prepared by the partial enzymatic hydrolysis of quercetin diglycoside (rutin, RU). In this paper, the effects of enzyme types, enzyme amounts, and substrate concentrations on the reactivity were investigated using a series of Pecinex TM multi-enzymes. The reaction, when a 8 ml of Ultra Clear to 1 g of RU was applied with the substrate concentration of 1% at 50 ℃, was found to be optimum, based on the reaction rate and the selectivity to IQ. Keywords

show abstract

Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: Evidence for the inhibition of angiotensin converting enzyme

Cited by 134 publications

References 45 publications

Antihypertensive Effects of Apple Peel Extract on Spontaneously Hypertensive Rats

Antihypertensive Effects of Apple Peel Extract on Spontaneously Hypertensive Rats

Isoquercitrin Inhibits Hydrogen Peroxide-Induced Apoptosis of EA.hy926 Cells via the PI3K/Akt/GSK3β Signaling Pathway

Study on the Synthesis of Isoquercitrin by Enzymatic Partial Hydrolysis

Contact Info

Product

Resources

About