Antihypertensive effects of extract from Picrasma quassiodes (D. Don) Benn. in spontaneously hypertensive rats

Zhao, Wenna; Yu, Jian; Su, Qi; Liang, Jinru; Zhao, Lina; Zhang, Yongmin; Sun, Wenli

doi:10.1016/j.jep.2012.10.049

Cited by 26 publications

(13 citation statements)

References 24 publications

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“…(PQ) is widely distributed in most areas of mainland China, and the branches of this plant are used as a traditional folk medicine for the treatment of a variety of diseases, such as hypertension (22), colitis (23), gastroenteritis and cancer (24). The major active compounds in PQ are β-carbolines and canthin-6-one alkaloids (24) which have been reported to possess various activities, such as anti-inflammatory and anti-hypertensive activities (22,23). 4-Methoxy-5-hydroxycanthin-6-one is one of the major active constituents of β-carbolines and cathinone alkaloids isolated from PQ.…”

Section: Picrasma Quassiodes (D Don) Benn Attenuates Lipopolysacchamentioning

confidence: 99%

Picrasma quassiodes (D. Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury

Lee

Park

Shin

et al. 2016

International Journal of Molecular Medicine

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Picrasma quassiodes (D.Don) Benn. (PQ) is a medicinal herb belonging to the family Simaroubaceae and is used as a traditional herbal remedy for various diseases. In this study, we evaluated the effects of PQ on airway inflammation using a mouse model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) and LPS-stimulated raw 264.7 cells. ALI was induced in C57BL/6 mice by the intranasal administration of LPS, and PQ was administered orally 3 days prior to exposure to LPS. Treatment with PQ significantly attenuated the infiltration of inflammatory cells in the bronchoalveolar lavage fluid (BALF). PQ also decreased the production of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 in BALF. In addition, PQ inhibited airway inflammation by reducing the expression of inducible nitric oxide synthase (iNOS) and by increasing the expression of heme oxygenase-1 (HO-1) in the lungs. Furthermore, we demonstrated that PQ blocked the activation of mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) in the lungs of mice with LPS-induced ALI. In the LPS-stimulated RAW 264.7 cells, PQ inhibited the release of pro-inflammatory cytokines and increased the mRNA expression of monocyte chemoattractant protein-1 (MCP-1). Treatment with PQ decreased the translocation of nuclear factor (NF)-κB to the nucleus, and increased the nuclear translocation of nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of HO-1. PQ also inhibited the activation of p38 in the LPS-stimulated RAW 264.7 cells. Taken together, our findings demonstrate that PQ exerts anti-inflammatory effects against LPS-induced ALI, and that these effects are associated with the modulation of iNOS, HO-1, NF-κB and MAPK signaling. Therefore, we suggest that PQ has therapeutic potential for use in the treatment of ALI.

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Section: Picrasma Quassiodes (D Don) Benn Attenuates Lipopolysacchamentioning

confidence: 99%

Picrasma quassiodes (D. Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury

Lee

Park

Shin

et al. 2016

International Journal of Molecular Medicine

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“…The aqueous extract obtained from Thymus serpyllum L. (wild thym: TE) showed an IC 50 value of 122.36 µg/mL for NO scavenging activity, while TE protected against hypertension in an experimental model [ 6 ]. Moreover, the IC 50 value of several compounds isolated from Picrasma quassiodes (D. Don) Benn (PQB) with antihypertensive effects had NO scavenging activity that ranged from 2.87 to 14.58 µg/mL [ 24 , 25 , 26 ]. In this study, the IC 50 value of EEtRLP was very similar to that of TE, although the target molecule for the assay differed in both studies.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of ethanol extracts of RedLiriope platyphyllaon vascular dysfunction in the aorta of spontaneously hypertensive rats

et al. 2015

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Some biological effects of Red Liriope platyphylla (RLP) on various chronic diseases including Alzheimer's disease, diabetes and obesity were suggested after a report of the production from Liriope platyphylla (L. platyphylla, LP) roots using a steaming process. To examine the beneficial effects of ethanol extracts RLP (EEtRLP) on the vascular dysfunction of hypertension, alterations in key factors related to vascular regulation and antioxidant conditions were investigated in spontaneously hypertensive rats (SHR) after EEtRLP treatment for 2 weeks. High levels of 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity were detected in 500 or 1,000 mg/mL EEtRLP. Although no significant improvement of systolic blood pressure or aortic wall thickness were observed in the EEtRLP treated group, the expression level of angiotensin converting enzyme (ACE) and ACE2 increased significantly after EEtRLP treatment. Moreover, the concentration of aldosterone and K ion in serum rapidly recovered in the EEtRLP treated group relative to the vehicle treated group. Furthermore, the endothelial nitric oxide synthase (eNOS) expression and superoxide dismutase (SOD) activity were significantly increased in the EEtRLP treated group relative to the vehicle treated group, while the level of malondialdehyde (MDA) and NOx in the serum of the same group were recovered to the level of Wistar Kyoto (WKY) rats. Overall, the results presented herein provide novel evidence that EEtRLP treatment may improve vascular dysfunction in the aorta of the SHR through up regulation of the antioxidant state and down regulation of aldosterone and K ion concentration. These results also suggest that EEtRLP may be a potential candidate for treatment of various chronic diseases showing vascular dysfunction.

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“…Using of plants and plant parts for therapeutic purposes has a long history. Recently, many studies have been performed to find more suitable antihypertensive agents from natural sources …”

Section: Discussionmentioning

confidence: 99%

“…In a study by Alirezaei et al ., oleuropein attenuates ethanol‐induced oxidative stress and lipid peroxidation in this study possibly by two pathways: first, by the rapid conversion of H 2 O 2 to H 2 O and by preventing H 2 O 2 accumulation; and second, by quenching the hydroxyl radicals in which trapping HO − leads to oxidative breakdown of the phenolic compounds. Several studies have demonstrated the ability of phenolic compounds to inhibit oxidative stress in rats through various mechanisms . Thus, the potent antioxidant effect exerted by phenolic compounds might contribute to protecting the structure of phospholipids in rats.…”

Section: Discussionmentioning

confidence: 99%

Propolis reduces oxidative stress in l‐NAME‐induced hypertension rats

Talas

2013

Cell Biochemistry & Function

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The inhibition in the synthesis or bioavailability of nitric oxide (NO) has an important role in progress of hypertension. The blocking of nitric oxide synthase activity may cause vasoconstriction with the formation of reactive oxygen species (ROS). Propolis is a resinous substance collected by honey bees from various plants. Propolis has biological and pharmacological properties. The aim of this study was to examine the effect of propolis on catalase (CAT) activity, malondialdehyde (MDA) and NO levels in the testis tissues of hypertensive rats by Nω-nitro-l-arginine methyl ester (l-NAME). Rats have received nitric oxide synthase inhibitor (l-NAME, 40 mg kg(-1) , intraperitoneally) for 15 days to produce hypertension and propolis (200 mg kg(-1) , by gavage) during the last 5 days. MDA level in l-NAME-treated group significantly increased compared with control group (P < 0.01). MDA level of l-NAME + propolis-treated rats significantly reduced (P < 0.01) compared with l-NAME-treated group. CAT activity and NO level significantly reduced (P < 0.01) in l-NAME group compared with control group. There were no statistically significant increases in the CAT activity and NO level of the l-NAME + propolis group compared with the l-NAME-treated group (P > 0.01). These results suggest that propolis changes CAT activity, NO and MDA levels in testis of l-NAME-treated animals, and so it may modulate the antioxidant system.

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Antihypertensive effects of extract from Picrasma quassiodes (D. Don) Benn. in spontaneously hypertensive rats

Cited by 26 publications

References 24 publications

Picrasma quassiodes (D. Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury

Picrasma quassiodes (D. Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury

Beneficial effects of ethanol extracts of RedLiriope platyphyllaon vascular dysfunction in the aorta of spontaneously hypertensive rats

Propolis reduces oxidative stress in l‐NAME‐induced hypertension rats

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