1981
DOI: 10.1007/bf00562798
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Antihypertensive effects of a novel peripheral vasodilator, Ro 12-4713

Abstract: The effects of Ro 12-4713, a vasodilator, on blood pressure and heart rate, were tested in 13 ambulant patients with mild to severe hypertension. The patients received Ro 12-4713 in total oral doses ranging from 1.5 to 4 mg/kg over a 3-5 day period. Standard laboratory tests were done 24 h before and after the study. Standing and supine blood pressure and heart rate were determined before, and every hour for 6-8 h after drug administration. ECGs were recorded before, during and at the end of each study day. Ro… Show more

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Cited by 5 publications
(4 citation statements)
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“…As shown by the study of segmental motion, with all the limitations of this procedure, Ro 12-4713 did not induce detectable dyskinesia. The changes in EF and ER reflect a decreased 'af terload', as expected from other studies [1,2]. The resting EDV did not change significantly, but the exercise EDV decreased by 25.6% (p < 0.005).…”
Section: Discussionsupporting
confidence: 71%
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“…As shown by the study of segmental motion, with all the limitations of this procedure, Ro 12-4713 did not induce detectable dyskinesia. The changes in EF and ER reflect a decreased 'af terload', as expected from other studies [1,2]. The resting EDV did not change significantly, but the exercise EDV decreased by 25.6% (p < 0.005).…”
Section: Discussionsupporting
confidence: 71%
“…6 patients (33.3%) presented with side effects: ankle edema and periorbital swelling, 4 patients presented also an increase of myocardial ischemia (S-T changes). We observed similar side effects in patients treated with Ro 12-4713 for arterial hypertension [2]. Similar side effects are reported with minoxidil [7], Furthermore, in another study we have treated 102 hypertensive patients with Ro 12-4713 for 6-18 months (mean duration 9.3 months): severe hypertrichosis (70% of pa tients), myocardial ischemia (20% of pa tients) and diuretic-resistant water retention (45% of patients) were observed after the 10th week of therapy; they were severe enough to require withdrawal of the therapy in most of the cases, and forced us to stop the treatment in spite of good antihypertensive efficacy [9], Lastly, a few months ago, the drug was been totally withdrawn from clinics because of toxicity in the long-term cancerogenetic studies in animals [1].…”
Section: Discussionsupporting
confidence: 67%
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