Antihypertensive Effects, Determined by a Telemetry Method, of Trichloromethiazide and 7–o‐ethylfangchinoline, a Derivative of Tetrandrine, in Spontaneously Hypertensive Rats
Abstract:1. The antihypertensive effects of 10 mg/kg trichloromethiazide (TCM), 10 mg/kg 7-0-ethylfangchinoline (7-0-EFC) and the combination of these drugs given orally once daily for 2 weeks were investigated by measuring the blood pressure (BP), heart rate (HR) and activity in conscious, freely moving spontaneously hypertensive rats (SHR) fitted with a telemetry device.2. Clear diurnal rhythms of the HR and activity in synchrony with the light/dark cycle were observed during therapy, whereas the BP rhythm was obscur… Show more
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