Antihypertensive Effect of Pleurotus nebrodensis in Spontaneously Hypertensive Rats

Miyazawa, Noriko; Okazaki, Mitsuyo; Ohga, Shoji

doi:10.5650/jos.57.675

Cited by 46 publications

(26 citation statements)

References 12 publications

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“…tuoliensis, is one of the most widely cultivated mushrooms in China. It is praised as white Ganoderma lucidum because it is not only delicious and nutrient, but also has various pharmaceutical activities such as antitumor (Choi et al, 2006), antihypertensive (Miyazawa et al, 2008) and antiviral (Lv et al, 2009) properties. Higher temperature is one of the important environmental factors that influence mushroom growth and development.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide alleviates heat stress-induced oxidative damage in Pleurotus eryngii var. tuoliensis

WeiWei

Huang

Chen

et al. 2012

Fungal Genetics and Biology

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Section: Introductionmentioning

confidence: 99%

Nitric oxide alleviates heat stress-induced oxidative damage in Pleurotus eryngii var. tuoliensis

WeiWei

Huang

Chen

et al. 2012

Fungal Genetics and Biology

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“…A few reports have investigated that polysaccharide from food ingredients present hypertensive activity via inhibition of ACE activity. Miyazawa and others [8] showed that polysaccharide fraction of mushroom species such as Pleurotus nebrodensis in SHR reduced blood pressure via the inhibition of angiotensin conversion. In addition, pectin hydroxamic acid shows the dose-dependent inhibitory activity of ACE [20].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, several reports have been published on anti-hypertensive effect of natural polysaccharide and presented the following: the polysaccharides fraction from American ginseng berry extract has a significant anti-hyperglycemic activity [7]. Treatment with polysaccharide fraction of mushroom species such as Pleurotus nebrodensis in SHR showed antihypertensive effect via the inhibition of angiotensin conversion [8]. We previously reported [9] that the anti-hypertensive action of macromolecules such as crude polysaccharides from Gastrodia rhizome in SHR is significantly stronger than that of the protein fraction and low-molecular-weight fraction (phenolic compound).…”

Section: Introductionmentioning

confidence: 99%

Effects of Acidic Polysaccharides from Gastrodia Rhizome on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed a High-Fat Diet

Lee

Kim

Han

et al. 2012

IJMS

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The effects of acidic polysaccharides purified from Gastrodia rhizome on blood pressure and serum lipid levels in spontaneously hypertensive rats (SHR) fed a high-fat diet were investigated. Acidic polysaccharides were purified from crude polysaccharides by DEAE-Sepharose CL-6B. Thirty-six male SHR were randomly divided into three groups: Gastrodia rhizome crude polysaccharide (A), acidic polysaccharide (B) groups, and a control group (C). A 5-week oral administration of all treatment groups was performed daily in 3- to 8-week-old SHRs with a dose of 6 mg/kg of body weight/day. After 5 weeks of treatment, total cholesterol in the acidic polysaccharide group, at 69.7 ± 10.6 mg/dL, was lower than in the crude polysaccharide group (75.0 ± 6.0 mg/dL) and the control group (89.2 ± 7.4 mg/dL). In addition, triglyceride and low-density lipoprotein cholesterol levels in the acidic polysaccharide group were lower than in the crude polysaccharide and control groups. The atherogenic index of the acidic polysaccharide group was 46.3% lower than in the control group. Initial blood pressure after the initial three weeks on the high-fat diet averaged 195.9 ± 3.3 mmHg among all rats. Compared with the initial blood pressure, the final blood pressure in the control group was increased by 22.8 mmHg, whereas it decreased in the acidic polysaccharide group by 14.9 mmHg. These results indicate that acidic polysaccharides from Gastrodia rhizome reduce hypertension and improve serum lipid levels.

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“…It has been reported that mushroom species such as Lentinula edodes , Ganoderma lucidum , Grifola frondosa , Pleurotus cornucopiae , and Pleurotus nebrodensis have antihypertension activities; moreover, their mechanisms of action have been suggested to involve the decrease blood pressure by improvement in blood levels of triglyceride and cholesterol as well as kidney function and inhibition of angiotensin-converting enzymes [3, 4, 27, 28]. However, this is the first report to indicate an antihypertensive mechanism involving an improvement in endothelial signaling due to mushrooms.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of Sparassis crispa on stroke through activation of Akt/eNOS pathway in brain of SHRSP

et al. 2010

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Sparassis crispa (S. crispa) is a mushroom used as a natural medicine that recently became cultivatable in Japan. In this study, we investigated not only the preventive effects of S. crispa against stroke and hypertension in stroke-prone spontaneously hypertensive rats (SHRSP) but also the mechanism involved by using studies of the cerebral cortex at a young age. Six-week-old male SHRSP were divided into 2 groups, a control group and an S. crispa group administered 1.5% S. crispa in feed, and we then observed their survival. In addition, rats of the same age were treated with 1.5% S. crispa for 4 weeks and we measured body weight, blood pressure, blood flow from the tail, NOx production, and the levels of expression of several proteins in the cerebral cortex by western blot analysis. Our results showed that the S. crispa group had a delayed incidence of stroke and death and significantly decreased blood pressure and increased blood flow after the administration. Moreover, the quantity of urinary excretion and the nitrate/nitrite concentration in cerebral tissue were higher than those of control SHRSP rats. In the cerebral cortex, phosphor-eNOS (Ser1177) and phosphor-Akt (Ser473) in S. crispa-treated SHRSP were increased compared with those of control SHRSP rats. In conclusion, S. crispa could ameliorate cerebrovascular endothelial dysfunction by promoting recovery of Akt-dependent eNOS phosphorylation and increasing NO production in the cerebral cortex. S. crispa may be useful for preventing stroke and hypertension.

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Antihypertensive Effect of Pleurotus nebrodensis in Spontaneously Hypertensive Rats

Cited by 46 publications

References 12 publications

Nitric oxide alleviates heat stress-induced oxidative damage in Pleurotus eryngii var. tuoliensis

Nitric oxide alleviates heat stress-induced oxidative damage in Pleurotus eryngii var. tuoliensis

Effects of Acidic Polysaccharides from Gastrodia Rhizome on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed a High-Fat Diet

Beneficial effect of Sparassis crispa on stroke through activation of Akt/eNOS pathway in brain of SHRSP

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