Antihypertensive effect of French maritime pine bark extract (Flavangenol): possible involvement of endothelial nitric oxide-dependent vasorelaxation

Kwak, Cheol; Kubo, Eriko; Fujii, Kiyotaka; Nishimura, Y.; Kobuchi, Shuhei; Ohkita, Mamoru; Yoshimura, Mitsu; Kiso, Yoshinobu; Matsumura, Yasuo

doi:10.1097/hjh.0b013e3283186994

Cited by 31 publications

(32 citation statements)

References 39 publications

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“…PYC possesses a potent endothelium-dependent vasorelaxant activity on rat aortic rings in vitro, and vasorelaxation is suppressed by pretreatment with a nonselective nitric oxide (NO) synthase (NOS) inhibitor (Fitzpatrick et al, 1998), suggesting that PYC-induced endothelium-dependent vasorelaxation is associated with NOS. Indeed, a report in 2009 demonstrated that PYC-induced endothelium-dependent vasorelaxation was mediated by the endothelial NOS-NO-soluble guanylate cyclase signaling system (Kwak et al, 2009). Other studies involving hypertensive patients showed that dietary PYC supplementation decreases plasma endothelin-1 concentrations, whereas NO metabolite levels in plasma tend to increase, suggesting PYC has beneficial effects on endothelial function in hypertensive patients (Liu et al, 2004).…”

Section: Organ Protective Effects Of Pbe Cardiovascular Protectionmentioning

confidence: 99%

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Jiao

Zhang

et al. 2015

J Pharmacol Exp Ther

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Proanthocyanidins are among the most abundant constituents in pine bark extracts (PBEs). This review summarizes medical research on PBEs from Pinus pinaster, Pinus radiata, Pinus massoniana, and other less well characterized species. The precise mechanisms of the important physiologic functions of PBE components remain to be elucidated, but there is evidently great potential for the identification and development of novel antioxidant, anti-inflammatory, cardiovascular, neuroprotective, and anticancer medicines. Although toxicological data for PBEs are limited, no serious adverse effects have been reported. PBEs, therefore, may have potential as nutraceuticals and pharmaceuticals and should be safe for use as food ingredients.

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Section: Organ Protective Effects Of Pbe Cardiovascular Protectionmentioning

confidence: 99%

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Jiao

Zhang

et al. 2015

J Pharmacol Exp Ther

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“…In addition, they found also that the oligomeric (from dimers up to heptamers) proanthocyanidin fraction obtained by fractionation of PBE by Sephadex LH-20 liquid chromatography is mainly responsible for the PBE-induced vasorelaxation, although its mechanisms were not elucidated. On the other hand, our study demonstrated that Flavangenolinduced endothelium-dependent vasorelaxation was mediated by the eNOS -NO -soluble guanylate cyclase (sGC) signaling system (17). Flavangenol-induced vasorelaxation was accompanied by the increased expression of phosphorylated-eNOS (Ser 1177 ) protein without affecting total eNOS protein level.…”

Section: Enhancement Of Nos System By Flavangenolmentioning

confidence: 73%

“…These antioxidative properties may be at least partly contributive to its protective effects against various cardiovascular diseases because increased oxidative stress is one of the major causal factors for the development of hypertension as described above (15,16). In fact, our recent study has shown that the development of DOCA-salt-induced hypertension was significantly suppressed by feeding a Flavangenolcontaining diet (17). We have reported also that O 2 − production in aortic segments tended to increase in the normal diet-fed DOCA-salt rats, but Flavangenol supplementation completely suppressed this augmentation.…”

Section: Antioxidative Effects Of Flavangenol In Hypertensionmentioning

confidence: 96%

Pharmacology in Health Foods: Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)

2011

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Abstract.Flavangenol is the French maritime pine bark extract (PBE). It consists of a concentrate of pine bark constituents such as catechin, taxifolin, and proanthocyanidins. Recent studies have shown that PBE has a strong antioxidant effect and exerts ameliorative effects on cardiovascular, skin, cognitive, and menstrual disorders, as well as in the context of other diseases and disease processes such as diabetes and inflammation. We have also obtained evidence that Flavangenol suppresses nuclear factor-kappa B (NF-κB) activation and the subsequent various NF-κB-induced gene expressions such as those of adhesion molecules and endothelin-1 in cultured vascular endothelial cells and that the antihypertensive effect of Flavangenol on deoxycorticosterone acetatesalt hypertensive rats is attributable to both its antioxidative property-related protective effects against endothelial dysfunction and the endothelium-dependent vasorelaxant effect, which is mediated by endothelial nitric oxide synthase activation. Furthermore, Flavangenol showed a renoprotective effect on ischemia/reperfusion-induced acute kidney injury in rats. These findings suggest that Flavangenol supplementation may be a promising candidate for the improvement of endothelial dysfunction and the prophylactic treatment of vascular diseases.Keywords: Flavangenol, hypertension, ischemia acute kidney injury, nitric oxide synthase, antioxidative effect, health food Forum MinireviewFig. 1. Chemical structure of oligomeric proanthocyanidin.

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“…Treatment with the diet of FG or ibuprofen was started at the beginning of induction. The concentrations of FG and ibuprofen diets were determined by other previous experiments, such as the effects on atherosclerosis ( 12 ) and hypertension ( 19 ), and our recent experiment ( 8 ).…”

Section: Animalsmentioning

confidence: 99%

Effects of Flavangenol, an Extract of French Maritime Pine Bark on Collagen-Induced Arthritis in Rats

Tsubata

Takagaki

Hirano³

et al. 2011

J Nutr Sci Vitaminol

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Summary Flavangenol (FG), an extract of French maritime pine bark ( Pinus maritime ) mainly contains proanthocyanidin in oligomers. It has many physiological effects, including antioxidant and anti-atherosclerosis. In this study, we evaluated the effects of FG on rat collagen-induced arthritis, a model of human rheumatoid arthritis. The rats were fed with the diet of control, 0.3% FG, or 1% FG for 4 wk after the induction of arthritis. The FG diets, compared with the control diet, suppressed the increase in arthritic score and swelling of the paws in a dose-dependent manner. Histopathological examination revealed evidence that the 1% FG diet suppressed acute and chronic articular lesions in the rats. In addition, the FG diets (0.3% and 1%) suppressed the production of nitric oxide in the plasma of the rats. These results suggest that dietary FG has beneficial effects on collagen-induced arthritis in rats by inhibiting the acute and chronic inflammatory reactions.

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Antihypertensive effect of French maritime pine bark extract (Flavangenol): possible involvement of endothelial nitric oxide-dependent vasorelaxation

Cited by 31 publications

References 39 publications

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Pharmacology in Health Foods: Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)

Effects of Flavangenol, an Extract of French Maritime Pine Bark on Collagen-Induced Arthritis in Rats

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